STRINGSTRING
LIMK2 LIMK2 SRC SRC EPHB4 EPHB4 ACTB ACTB LOC102731157 LOC102731157 EFNA1 EFNA1 VAV3 VAV3 APH1B APH1B ARHGEF28 ARHGEF28 ARPC3 ARPC3 GRIN1 GRIN1 EPHB2 EPHB2 EPHB3 EPHB3 AP2M1 AP2M1 EFNB3 EFNB3 PAK1 PAK1 SDCBP SDCBP ELSPBP1 ELSPBP1 MMP9 MMP9 ROCK2 ROCK2 ARPC4 ARPC4 CFL1 CFL1 CLTC CLTC ARHGEF7 ARHGEF7 AP2A2 AP2A2 LOC102750652 LOC102750652 PSEN2 PSEN2 PSENEN PSENEN PAK2 PAK2 EPHA4 EPHA4 CLTA CLTA TIAM1 TIAM1 DNM1 DNM1 ARPC5L ARPC5L AP2A1 AP2A1 LOC102729978 LOC102729978 CDC42 CDC42 CLTCL1 CLTCL1 LOC102741827 LOC102741827 FNDC3B FNDC3B ACTR3B ACTR3B VAV2 VAV2 FNDC3A FNDC3A LOC102725560 LOC102725560 EPHA1 EPHA1 ACTL8 ACTL8 NCK2 NCK2 LOC102738455 LOC102738455 LOC102741259 LOC102741259 LOC102750414 LOC102750414 NCSTN NCSTN LOC102742564 LOC102742564 ARPC1B ARPC1B LOC102737768 LOC102737768 ARPC1A ARPC1A LOC102748833 LOC102748833 LOC102725895 LOC102725895 LOC102733359 LOC102733359 ACTG1 ACTG1 EPHA7 EPHA7 WASL WASL RASA1 RASA1 LOC102738522 LOC102738522 YES1 YES1 APH1A APH1A EPHA3 EPHA3 ARPC5 ARPC5 EPHA5 EPHA5 LOC102728392 LOC102728392 LOC102740357 LOC102740357 CFL2 CFL2 LOC102731357 LOC102731357 LOC102734862 LOC102734862
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LIMK2LIM domain kinase 2 isoform X1. (638 aa)
SRCTyrosine-protein kinase. (536 aa)
EPHB4Ephrin type-B receptor 4 isoform X1. (988 aa)
ACTBActin, cytoplasmic 1. (375 aa)
LOC102731157ARF GTPase-activating protein GIT1-like. (191 aa)
EFNA1ephrin-A1 isoform X1; Belongs to the ephrin family. (205 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X2. (847 aa)
APH1BGamma-secretase subunit APH-1B isoform X1. (257 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1389 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1 isoform X1. (943 aa)
EPHB2Ephrin type-B receptor 2-like isoform X1. (545 aa)
EPHB3Ephrin type-B receptor 3. (883 aa)
AP2M1AP-2 complex subunit mu. (189 aa)
EFNB3ephrin-B3; Belongs to the ephrin family. (340 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
SDCBPSyntenin-1 isoform X1. (298 aa)
ELSPBP1LOW QUALITY PROTEIN: epididymal sperm-binding protein 1. (223 aa)
MMP9Matrix metalloproteinase-9. (704 aa)
ROCK2Rho-associated protein kinase 2. (850 aa)
ARPC4Actin-related protein 2/3 complex subunit 4 isoform X2. (78 aa)
CFL1Cofilin-1 isoform X2; Belongs to the actin-binding proteins ADF family. (219 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (625 aa)
AP2A2AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (936 aa)
LOC102750652Actin-related protein 3-like isoform X1; Belongs to the actin family. (418 aa)
PSEN2Presenilin-2. (115 aa)
PSENENGamma-secretase subunit PEN-2 isoform X1. (101 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
EPHA4Ephrin type-A receptor 4-like isoform X2. (949 aa)
CLTAClathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (171 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X1. (1591 aa)
DNM1Dynamin-1 isoform X2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
AP2A1AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (978 aa)
LOC102729978Beta-actin-like protein 2-like isoform X1. (376 aa)
CDC42Cell division control protein 42 homolog. (160 aa)
CLTCL1Clathrin heavy chain 2. (825 aa)
LOC102741827ephrin-B1-like; Belongs to the ephrin family. (247 aa)
FNDC3BFibronectin type III domain-containing protein 3B. (1155 aa)
ACTR3BActin-related protein 3B-like isoform X2; Belongs to the actin family. (286 aa)
VAV2Guanine nucleotide exchange factor VAV2. (357 aa)
FNDC3AFibronectin type-III domain-containing protein 3A isoform X2. (1199 aa)
LOC102725560Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (225 aa)
EPHA1Ephrin type-A receptor 1. (976 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (366 aa)
NCK2Cytoplasmic protein. (380 aa)
LOC102738455Destrin-like; Belongs to the actin-binding proteins ADF family. (165 aa)
LOC102741259Serine/threonine-protein kinase PAK 3-like. (339 aa)
LOC102750414Formin-2-like. (76 aa)
NCSTNNicastrin. (602 aa)
LOC102742564Rho-associated protein kinase 2-like. (530 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
LOC102737768Actin-related protein 2/3 complex subunit 1A-like. (101 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (370 aa)
LOC102748833Tyrosine-protein kinase. (375 aa)
LOC102725895Ephrin type-A receptor 8-like. (743 aa)
LOC102733359ephrin-A4-like; Belongs to the ephrin family. (166 aa)
ACTG1LOW QUALITY PROTEIN: actin, gamma 1. (411 aa)
EPHA7Ephrin type-A receptor 7-like isoform X1. (998 aa)
WASLNeural Wiskott-Aldrich syndrome protein. (487 aa)
RASA1Ras GTPase-activating protein 1. (1039 aa)
LOC102738522Fibronectin type III domain containing protein 3C1-like. (1404 aa)
YES1Tyrosine-protein kinase. (541 aa)
APH1AGamma-secretase subunit APH-1A isoform X1. (265 aa)
EPHA3Ephrin type-A receptor 3 isoform X1. (984 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (151 aa)
EPHA5Ephrin type-A receptor 5 isoform X1. (1039 aa)
LOC102728392ephrin-A5-like; Belongs to the ephrin family. (191 aa)
LOC102740357Cell division control protein 42 homolog. (191 aa)
CFL2Cofilin-2; Belongs to the actin-binding proteins ADF family. (166 aa)
LOC102731357Clathrin light chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin light chain family. (229 aa)
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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