STRINGSTRING
RFC4 RFC4 LOC102746412 LOC102746412 LOC102748583 LOC102748583 TMEM55A TMEM55A RICTOR RICTOR ANKRD32 ANKRD32 PRKAG2 PRKAG2 TAF13 TAF13 MEIOB MEIOB RHNO1 RHNO1 CHEK2 CHEK2 TAF3 TAF3 PRMT5 PRMT5 PML PML POU4F2 POU4F2 PIN1 PIN1 SETD9 SETD9 HIPK3 HIPK3 MDM2 MDM2 PPP2R5C PPP2R5C PIP4K2C PIP4K2C AKT3 AKT3 TAF12 TAF12 USP2 USP2 LOC102740403 LOC102740403 PRKAB1 PRKAB1 PRDM1 PRDM1 BRPF1 BRPF1 TP53 TP53 RAD17 RAD17 TAF9 TAF9 PPP1R13L PPP1R13L CSNK2B CSNK2B LY6G5B LY6G5B EHMT2 EHMT2 AKT1 AKT1 AURKB AURKB CHD4 CHD4 CCNG1 CCNG1 TAF11 TAF11 RAD9A RAD9A ING2 ING2 RFC5 RFC5 TP53RK TP53RK POU4F1 POU4F1 LOC102726984 LOC102726984 LOC102750126 LOC102750126 LOC102739775 LOC102739775 ATRIP ATRIP LOC102733263 LOC102733263 ING5 ING5 TAF9B TAF9B LOC102746125 LOC102746125 LOC102725945 LOC102725945 CDK3 CDK3 HIPK1 HIPK1 ZNF385A ZNF385A CDK2 CDK2 DNA2 DNA2 RFC3 RFC3 FOXP4 FOXP4 LOC102732031 LOC102732031 LOC102726777 LOC102726777 KXD1 KXD1 UBA52 UBA52 EXO1 EXO1 LOC102747337 LOC102747337 TP73 TP73 RNF34 RNF34 LOC102743783 LOC102743783 LOC102733867 LOC102733867 LOC102727190 LOC102727190 CDK5 CDK5 LOC102746862 LOC102746862 PRKAG1 PRKAG1 LOC102750498 LOC102750498 TDRD3 TDRD3 TP53INP1 TP53INP1 EP300 EP300 MTA2 MTA2 TTC5 TTC5 L3MBTL1 L3MBTL1 TMEM55B TMEM55B SUPT16H SUPT16H LOC102728200 LOC102728200 TAF7 TAF7 MDM4 MDM4 PPP2CB PPP2CB NUAK2 NUAK2 RBBP7 RBBP7 L3MBTL3 L3MBTL3 RPA3 RPA3 TBPL2 TBPL2 BRPF3 BRPF3 HIPK2 HIPK2 RAD1 RAD1 MTOR MTOR RAD50 RAD50 RBBP8 RBBP8 LOC102729636 LOC102729636 RBBP4 RBBP4 HDAC1 HDAC1 DYRK3 DYRK3 TAF6 TAF6 PRKAA1 PRKAA1 TAF15 TAF15 LOC102750322 LOC102750322 NOC2L NOC2L HUS1 HUS1 MAP2K6 MAP2K6 LOC102733070 LOC102733070 LOC102738981 LOC102738981 RPA4 RPA4 POU4F3 POU4F3 TBPL1 TBPL1 SGK1 SGK1 LOC102738828 LOC102738828 PHF20 PHF20 DYRK2 DYRK2 LOC102730998 LOC102730998 RFC2 RFC2 PWWP2A PWWP2A BRD9 BRD9 LOC102736146 LOC102736146 SSRP1 SSRP1 LOC102729166 LOC102729166 PRR5 PRR5 TBP TBP TAF4 TAF4 GATAD2A GATAD2A MAPKAP1 MAPKAP1 RMI1 RMI1 RFFL RFFL ATM ATM GATAD2B GATAD2B HDAC2 HDAC2 HIPK4 HIPK4 PIP4K2B PIP4K2B
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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RFC4Replication factor C subunit 4. (363 aa)
LOC102746412Replication protein A 32 kDa subunit-like. (124 aa)
LOC1027485835'-AMP-activated protein kinase subunit gamma-2-like. (129 aa)
TMEM55APhosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (257 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1732 aa)
ANKRD32Ankyrin repeat domain-containing protein 32 isoform X1. (1057 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2-like isoform X2. (327 aa)
TAF13Transcription initiation factor TFIID subunit 13. (124 aa)
MEIOBMeiosis-specific with OB domain-containing protein. (300 aa)
RHNO1RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1. (255 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X1. (544 aa)
TAF3Transcription initiation factor TFIID subunit 3. (774 aa)
PRMT5Protein arginine N-methyltransferase 5-like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (467 aa)
PMLProtein PML. (880 aa)
POU4F2POU domain protein. (408 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
SETD9SET domain-containing protein 9. (299 aa)
HIPK3Homeodomain-interacting protein kinase 3 isoform X1. (1215 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa)
PIP4K2CPhosphatidylinositol 5-phosphate 4-kinase type-2 gamma. (220 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
TAF12Transcription initiation factor TFIID subunit 12 isoform X1. (161 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (606 aa)
LOC102740403Dual specificity tyrosine-phosphorylation-regulated kinase 4-like; Belongs to the protein kinase superfamily. (308 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
PRDM1PR domain zinc finger protein 1 isoform X3. (818 aa)
BRPF1Peregrin isoform X1. (1220 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
RAD17Cell cycle checkpoint protein RAD17. (634 aa)
TAF9Transcription initiation factor TFIID subunit 9-like isoform X1. (265 aa)
PPP1R13LrelA-associated inhibitor. (827 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
LY6G5BLymphocyte antigen 6 complex locus protein G5b. (195 aa)
EHMT2Histone-lysine N-methyltransferase EHMT2 isoform X1. (1268 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
AURKBAurora kinase B isoform X1; Belongs to the protein kinase superfamily. (344 aa)
CHD4chromodomain-helicase-DNA-binding protein 4 isoform X2. (1912 aa)
CCNG1cyclin-G1; Belongs to the cyclin family. (295 aa)
TAF11Transcription initiation factor TFIID subunit 11 isoform X1. (211 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa)
ING2Inhibitor of growth protein. (280 aa)
RFC5Replication factor C subunit 5 isoform X1. (340 aa)
TP53RKTP53-regulating kinase. (254 aa)
POU4F1POU domain protein. (166 aa)
LOC102726984Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha-like. (135 aa)
LOC102750126Exonuclease 3'-5' domain-containing protein 2-like. (306 aa)
LOC102739775Breast cancer type 1 susceptibility protein homolog. (471 aa)
ATRIPATR-interacting protein. (597 aa)
LOC102733263Double-strand break repair protein MRE11A-like. (83 aa)
ING5Inhibitor of growth protein. (240 aa)
TAF9BTranscription initiation factor TFIID subunit 9B. (250 aa)
LOC102746125LOW QUALITY PROTEIN: cyclin-A1-like; Belongs to the cyclin family. (463 aa)
LOC102725945Cyclin-dependent kinase 1-like isoform X1; Belongs to the protein kinase superfamily. (297 aa)
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
HIPK1Homeodomain-interacting protein kinase 1 isoform X2. (1080 aa)
ZNF385AZinc finger protein 385A isoform X1. (386 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1061 aa)
RFC3Replication factor C subunit 3. (356 aa)
FOXP4Forkhead box protein P4 isoform X1. (681 aa)
LOC102732031Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (407 aa)
LOC102726777Cyclin-dependent kinase 5 activator 2-like. (98 aa)
KXD1kxDL motif-containing protein 1 isoform X1. (176 aa)
UBA52ubiquitin-60S ribosomal protein L40 isoform X3. (128 aa)
EXO1LOW QUALITY PROTEIN: exonuclease 1. (793 aa)
LOC102747337ubiquitin-40S ribosomal protein S27a-like. (154 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
RNF34E3 ubiquitin-protein ligase RNF34. (373 aa)
LOC102743783Histone-lysine N-methyltransferase EHMT1-like. (467 aa)
LOC102733867Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (235 aa)
LOC102727190Serine/threonine-protein kinase STK11-like. (545 aa)
CDK5Cyclin-dependent kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
LOC102746862ubiquitin-40S ribosomal protein S27a-like isoform X1. (156 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (298 aa)
LOC102750498Casein kinase II subunit alpha-like isoform X1; Belongs to the protein kinase superfamily. (391 aa)
TDRD3Tudor domain-containing protein 3-like isoform X1. (651 aa)
TP53INP1Tumor protein p53-inducible nuclear protein 1 isoform X1. (239 aa)
EP300Histone acetyltransferase p300. (2425 aa)
MTA2Metastasis-associated protein MTA2 isoform X1. (668 aa)
TTC5Tetratricopeptide repeat protein 5. (458 aa)
L3MBTL1Lethal(3)malignant brain tumor-like protein 1. (564 aa)
TMEM55BPhosphatidylinositol-4,5-bisphosphate 4-phosphatase; Catalyzes the hydrolysis of phosphatidylinositol-4,5- bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). (284 aa)
SUPT16HFACT complex subunit SPT16. (1047 aa)
LOC102728200ubiquitin-40S ribosomal protein S27a-like. (154 aa)
TAF7Transcription initiation factor TFIID subunit 7. (349 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (492 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
NUAK2NUAK family SNF1-like kinase 2. (633 aa)
RBBP7Histone-binding protein RBBP7 isoform X1. (469 aa)
L3MBTL3Lethal(3)malignant brain tumor-like protein 3 isoform X1. (780 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
TBPL2TATA box-binding protein-like protein 2. (344 aa)
BRPF3Bromodomain and PHD finger-containing protein 3 isoform X1. (1207 aa)
HIPK2Homeodomain-interacting protein kinase 2-like isoform X1. (1188 aa)
RAD1Cell cycle checkpoint protein RAD1. (281 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
RAD50DNA repair protein RAD50. (973 aa)
RBBP8DNA endonuclease RBBP8. (758 aa)
LOC102729636polyubiquitin-B-like. (77 aa)
RBBP4Histone-binding protein RBBP4. (380 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
DYRK3Dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1. (587 aa)
TAF6Transcription initiation factor TFIID subunit 6 isoform X1. (677 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
TAF15TATA-binding protein-associated factor 2N-like. (312 aa)
LOC102750322polyubiquitin-B-like. (153 aa)
NOC2LNucleolar complex protein 2 homolog. (687 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LOC102733070Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma-like. (117 aa)
LOC102738981Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma-like. (143 aa)
RPA4LOW QUALITY PROTEIN: replication protein A4, 30kDa. (262 aa)
POU4F3POU domain protein. (338 aa)
TBPL1TATA box-binding protein-like protein 1. (186 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
LOC102738828Targeting protein for Xklp2-like. (251 aa)
PHF20PHD finger protein 20. (1013 aa)
DYRK2Dual specificity tyrosine-phosphorylation-regulated kinase 2-like. (528 aa)
LOC102730998Protein arginine N-methyltransferase 5-like; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (138 aa)
RFC2Replication factor C subunit 2 isoform X1. (368 aa)
PWWP2APWWP domain-containing protein 2A. (755 aa)
BRD9Bromodomain-containing protein 9. (109 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
SSRP1FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] (709 aa)
LOC102729166Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma-like. (134 aa)
PRR5Proline-rich protein 5. (293 aa)
TBPTATA-box-binding protein. (322 aa)
TAF4Transcription initiation factor TFIID subunit 4. (668 aa)
GATAD2ATranscriptional repressor p66-alpha isoform X1. (543 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1. (122 aa)
RMI1recQ-mediated genome instability protein 1. (638 aa)
RFFLE3 ubiquitin-protein ligase rififylin. (298 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
GATAD2BTranscriptional repressor p66-beta. (593 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
HIPK4Homeodomain-interacting protein kinase 4. (615 aa)
PIP4K2BPhosphatidylinositol 5-phosphate 4-kinase type-2 beta. (416 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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