(17 nodes) FRS-mediated FGFR3 signaling network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NRAS	GTPase NRas. (189 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	KRAS	GTPase KRas isoform X2. (188 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	FGF23	Fibroblast growth factor 23. (177 aa)
	FGF18	Fibroblast growth factor 18. (116 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	LOC102744822	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
	LOC102728858	Fibroblast growth factor receptor substrate 2-like; Belongs to the TCP-1 chaperonin family. (251 aa)
	ERAS	GTPase ERas. (233 aa)
	FGFR3	Fibroblast growth factor receptor. (809 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	LOC102725595	Fibroblast growth factor receptor substrate 2-like. (316 aa)
	FRS3	Fibroblast growth factor receptor substrate 3. (495 aa)
	CSDE1	Cold shock domain-containing protein E1 isoform X1. (845 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	FGF18	A0A2U3XB03	A0A2U3YP56	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor 18.	0.426
CSDE1	FGFR3	A0A2U3XB03	A0A2U3XZ10	Cold shock domain-containing protein E1 isoform X1.	Fibroblast growth factor receptor.	0.523
CSDE1	PTPN11	A0A2U3XB03	A0A2U3XWH5	Cold shock domain-containing protein E1 isoform X1.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.483
ERAS	FGF18	A0A2U3Y423	A0A2U3YP56	GTPase ERas.	Fibroblast growth factor 18.	0.426
ERAS	FGF4	A0A2U3Y423	A0A2U3YP27	GTPase ERas.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.469
ERAS	FGFR3	A0A2U3Y423	A0A2U3XZ10	GTPase ERas.	Fibroblast growth factor receptor.	0.522
ERAS	PTPN11	A0A2U3Y423	A0A2U3XWH5	GTPase ERas.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.483
FGF16	FGF18	A0A2U3X658	A0A2U3YP56	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 18.	0.522
FGF16	FGF23	A0A2U3X658	A0A2U3Z274	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23.	0.685
FGF16	FGF4	A0A2U3X658	A0A2U3YP27	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.410
FGF16	FGFR3	A0A2U3X658	A0A2U3XZ10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.946
FGF16	KRAS	A0A2U3X658	A0A2U3X8L4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GTPase KRas isoform X2.	0.578
FGF16	LOC102725595	A0A2U3X658	A0A2U3XLS6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor substrate 2-like.	0.569
FGF16	LOC102728858	A0A2U3X658	A0A2U3YJ47	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor substrate 2-like; Belongs to the TCP-1 chaperonin family.	0.569
FGF16	LOC102744822	A0A2U3X658	A0A2U3Z5B6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...]	0.413
FGF16	NRAS	A0A2U3X658	A0A2U3XAI8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GTPase NRas.	0.483
FGF16	PTPN11	A0A2U3X658	A0A2U3XWH5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.543
FGF17	FGF23	A0A2U3YM04	A0A2U3Z274	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23.	0.702
FGF17	FGF4	A0A2U3YM04	A0A2U3YP27	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.428
FGF17	FGFR3	A0A2U3YM04	A0A2U3XZ10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor receptor.	0.928