(33 nodes) Termination of translesion DNA synthesis network (Leptonychotes weddellii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	POLE4	DNA polymerase epsilon subunit 4. (116 aa)
	UBE2L6	ubiquitin/ISG15-conjugating enzyme E2 L6; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
	RFC3	Replication factor C subunit 3. (356 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa)
	USP31	Ubiquitin carboxyl-terminal hydrolase 31; Belongs to the peptidase C19 family. (1155 aa)
	LOC102728200	ubiquitin-40S ribosomal protein S27a-like. (154 aa)
	ISG15	Ubiquitin-like protein ISG15. (169 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	LOC102741980	Ubiquitin carboxyl-terminal hydrolase 10-like. (396 aa)
	LOC102750322	polyubiquitin-B-like. (153 aa)
	POLE3	DNA polymerase epsilon subunit 3. (147 aa)
	LOC102729636	polyubiquitin-B-like. (77 aa)
	KIAA0101	PCNA-associated factor. (111 aa)
	RPA4	LOW QUALITY PROTEIN: replication protein A4, 30kDa. (262 aa)
	LOC102746862	ubiquitin-40S ribosomal protein S27a-like isoform X1. (156 aa)
	TRIM47	Tripartite motif-containing protein 47-like. (401 aa)
	RFC5	Replication factor C subunit 5 isoform X1. (340 aa)
	POLH	DNA polymerase eta isoform X1. (712 aa)
	TRIM65	Tripartite motif-containing protein 65. (381 aa)
	LOC102747337	ubiquitin-40S ribosomal protein S27a-like. (154 aa)
	UBA52	ubiquitin-60S ribosomal protein L40 isoform X3. (128 aa)
	KXD1	kxDL motif-containing protein 1 isoform X1. (176 aa)
	LOC102745606	Ubiquitin carboxyl-terminal hydrolase 43-like. (411 aa)
	LOC102731205	Ubiquitin carboxyl-terminal hydrolase 43-like; Belongs to the peptidase C19 family. (535 aa)
	RFC2	Replication factor C subunit 2 isoform X1. (368 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2277 aa)
	POLD4	DNA polymerase delta subunit 4. (107 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	LOC102746412	Replication protein A 32 kDa subunit-like. (124 aa)
	MEIOB	Meiosis-specific with OB domain-containing protein. (300 aa)
	RCBTB1	RCC1 and BTB domain-containing protein 1. (531 aa)
	RPA3	Replication protein A 14 kDa subunit. (121 aa)
	POLD2	DNA polymerase delta subunit 2. (469 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ISG15	LOC102728200	A0A2U3XMC4	A0A2U3XJ47	Ubiquitin-like protein ISG15.	ubiquitin-40S ribosomal protein S27a-like.	0.635
ISG15	LOC102729636	A0A2U3XMC4	A0A2U3XSD5	Ubiquitin-like protein ISG15.	polyubiquitin-B-like.	0.485
ISG15	LOC102731205	A0A2U3XMC4	A0A2U3YR97	Ubiquitin-like protein ISG15.	Ubiquitin carboxyl-terminal hydrolase 43-like; Belongs to the peptidase C19 family.	0.525
ISG15	LOC102741980	A0A2U3XMC4	A0A2U3XU95	Ubiquitin-like protein ISG15.	Ubiquitin carboxyl-terminal hydrolase 10-like.	0.562
ISG15	LOC102745606	A0A2U3XMC4	A0A2U3YT26	Ubiquitin-like protein ISG15.	Ubiquitin carboxyl-terminal hydrolase 43-like.	0.525
ISG15	LOC102746412	A0A2U3XMC4	A0A2U3YHP5	Ubiquitin-like protein ISG15.	Replication protein A 32 kDa subunit-like.	0.482
ISG15	LOC102746862	A0A2U3XMC4	A0A2U3Z815	Ubiquitin-like protein ISG15.	ubiquitin-40S ribosomal protein S27a-like isoform X1.	0.635
ISG15	LOC102747337	A0A2U3XMC4	A0A2U3YWH0	Ubiquitin-like protein ISG15.	ubiquitin-40S ribosomal protein S27a-like.	0.635
ISG15	LOC102750322	A0A2U3XMC4	A0A2U3XMJ2	Ubiquitin-like protein ISG15.	polyubiquitin-B-like.	0.590
ISG15	PCNA	A0A2U3XMC4	A0A2U3XVX8	Ubiquitin-like protein ISG15.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.984
ISG15	POLE	A0A2U3XMC4	A0A2U3YPZ1	Ubiquitin-like protein ISG15.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.606
ISG15	POLE3	A0A2U3XMC4	A0A2U3XUN3	Ubiquitin-like protein ISG15.	DNA polymerase epsilon subunit 3.	0.513
ISG15	POLE4	A0A2U3XMC4	A0A2U3XXJ0	Ubiquitin-like protein ISG15.	DNA polymerase epsilon subunit 4.	0.514
ISG15	POLH	A0A2U3XMC4	A0A2U3YZ56	Ubiquitin-like protein ISG15.	DNA polymerase eta isoform X1.	0.709
ISG15	RFC2	A0A2U3XMC4	A0A2U3YR32	Ubiquitin-like protein ISG15.	Replication factor C subunit 2 isoform X1.	0.531
ISG15	RFC3	A0A2U3XMC4	A0A2U3XC21	Ubiquitin-like protein ISG15.	Replication factor C subunit 3.	0.517
ISG15	RFC4	A0A2U3XMC4	A0A2U3YHT9	Ubiquitin-like protein ISG15.	Replication factor C subunit 4.	0.517
ISG15	RFC5	A0A2U3XMC4	A0A2U3Z142	Ubiquitin-like protein ISG15.	Replication factor C subunit 5 isoform X1.	0.517
ISG15	RPA4	A0A2U3XMC4	A0A2U3Z926	Ubiquitin-like protein ISG15.	LOW QUALITY PROTEIN: replication protein A4, 30kDa.	0.482
ISG15	TRIM47	A0A2U3XMC4	A0A2U3Z6U0	Ubiquitin-like protein ISG15.	Tripartite motif-containing protein 47-like.	0.491