STRINGSTRING
PRR5 PRR5 PHF20 PHF20 SGK1 SGK1 LOC102746862 LOC102746862 LOC102736146 LOC102736146 RNF34 RNF34 LOC102747337 LOC102747337 UBA52 UBA52 KXD1 KXD1 LOC102732031 LOC102732031 LOC102746125 LOC102746125 LOC102725945 LOC102725945 CDK3 CDK3 CDK2 CDK2 LOC102728200 LOC102728200 MDM4 MDM4 PPP2CB PPP2CB LOC102750322 LOC102750322 LOC102729636 LOC102729636 MTOR MTOR CCNG1 CCNG1 AKT1 AKT1 TP53 TP53 PRDM1 PRDM1 USP2 USP2 AKT3 AKT3 PPP2R5C PPP2R5C MDM2 MDM2 RICTOR RICTOR ATM ATM RFFL RFFL MAPKAP1 MAPKAP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRR5Proline-rich protein 5. (293 aa)
PHF20PHD finger protein 20. (1013 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
LOC102746862ubiquitin-40S ribosomal protein S27a-like isoform X1. (156 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
RNF34E3 ubiquitin-protein ligase RNF34. (373 aa)
LOC102747337ubiquitin-40S ribosomal protein S27a-like. (154 aa)
UBA52ubiquitin-60S ribosomal protein L40 isoform X3. (128 aa)
KXD1kxDL motif-containing protein 1 isoform X1. (176 aa)
LOC102732031Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (407 aa)
LOC102746125LOW QUALITY PROTEIN: cyclin-A1-like; Belongs to the cyclin family. (463 aa)
LOC102725945Cyclin-dependent kinase 1-like isoform X1; Belongs to the protein kinase superfamily. (297 aa)
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
LOC102728200ubiquitin-40S ribosomal protein S27a-like. (154 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (492 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
LOC102750322polyubiquitin-B-like. (153 aa)
LOC102729636polyubiquitin-B-like. (77 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
CCNG1cyclin-G1; Belongs to the cyclin family. (295 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
PRDM1PR domain zinc finger protein 1 isoform X3. (818 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (606 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
RICTORRapamycin-insensitive companion of mTOR isoform X1. (1732 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
RFFLE3 ubiquitin-protein ligase rififylin. (298 aa)
MAPKAP1Target of rapamycin complex 2 subunit MAPKAP1. (122 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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