(5 nodes) Fibroblast growth factor network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	FGF18	Fibroblast growth factor 18. (116 aa)
	LOC102737823	Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family. (115 aa)
	LOC102744822	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
	FGF23	Fibroblast growth factor 23. (177 aa)
	FSCN2	Fascin-2 isoform X1. (513 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FGF18	FGF23	A0A2U3YP56	A0A2U3Z274	Fibroblast growth factor 18.	Fibroblast growth factor 23.	0.763
FGF18	LOC102737823	A0A2U3YP56	A0A2U3YNM9	Fibroblast growth factor 18.	Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family.	0.486
FGF18	LOC102744822	A0A2U3YP56	A0A2U3Z5B6	Fibroblast growth factor 18.	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...]	0.556
FGF23	FGF18	A0A2U3Z274	A0A2U3YP56	Fibroblast growth factor 23.	Fibroblast growth factor 18.	0.763
FGF23	LOC102737823	A0A2U3Z274	A0A2U3YNM9	Fibroblast growth factor 23.	Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family.	0.659
FGF23	LOC102744822	A0A2U3Z274	A0A2U3Z5B6	Fibroblast growth factor 23.	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...]	0.706
LOC102737823	FGF18	A0A2U3YNM9	A0A2U3YP56	Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 18.	0.486
LOC102737823	FGF23	A0A2U3YNM9	A0A2U3Z274	Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23.	0.659
LOC102737823	LOC102744822	A0A2U3YNM9	A0A2U3Z5B6	Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...]	0.575
LOC102744822	FGF18	A0A2U3Z5B6	A0A2U3YP56	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...]	Fibroblast growth factor 18.	0.556
LOC102744822	FGF23	A0A2U3Z5B6	A0A2U3Z274	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...]	Fibroblast growth factor 23.	0.706
LOC102744822	LOC102737823	A0A2U3Z5B6	A0A2U3YNM9	Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...]	Fibroblast growth factor 19-like; Belongs to the heparin-binding growth factors family.	0.575