(8 nodes) (2013) The ER-Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis. network (Leptonychotes weddellii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	LOC102726286	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (78 aa)
	LOC102746084	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
	ATG14	Beclin 1-associated autophagy-related key regulator. (492 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (255 aa)
	ARF1	ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
	VANGL2	Vang-like protein. (521 aa)
	CTSD	Cathepsin D; Belongs to the peptidase A1 family. (410 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG14	A0A2U3XZP0	A0A2U3XYI3	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Beclin 1-associated autophagy-related key regulator.	0.892
ATG12	ATG5	A0A2U3XZP0	A0A2U3Y6R5	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	CTSD	A0A2U3XZP0	A0A2U3Z5S6	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Cathepsin D; Belongs to the peptidase A1 family.	0.647
ATG14	ATG12	A0A2U3XYI3	A0A2U3XZP0	Beclin 1-associated autophagy-related key regulator.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.892
ATG14	ATG5	A0A2U3XYI3	A0A2U3Y6R5	Beclin 1-associated autophagy-related key regulator.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.877
ATG5	ATG12	A0A2U3Y6R5	A0A2U3XZP0	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	ATG14	A0A2U3Y6R5	A0A2U3XYI3	Autophagy protein 5; Involved in autophagic vesicle formation.	Beclin 1-associated autophagy-related key regulator.	0.877
ATG5	CTSD	A0A2U3Y6R5	A0A2U3Z5S6	Autophagy protein 5; Involved in autophagic vesicle formation.	Cathepsin D; Belongs to the peptidase A1 family.	0.593
CTSD	ATG12	A0A2U3Z5S6	A0A2U3XZP0	Cathepsin D; Belongs to the peptidase A1 family.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.647
CTSD	ATG5	A0A2U3Z5S6	A0A2U3Y6R5	Cathepsin D; Belongs to the peptidase A1 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.593