(12 nodes) (2016) Measuring the immune system of the three-spined stickleback - investigating natural variation by quantifying immune expression in the laboratory and the wild. network (Leptonychotes weddellii)

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Your Input:
	IL13	Interleukin-13. (133 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (131 aa)
	IL10	Interleukin-10. (178 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
	RPL13A	60S ribosomal protein L13a isoform X1; Belongs to the universal ribosomal protein uL13 family. (203 aa)
	CMIP	c-Maf-inducing protein. (549 aa)
	IL9	Interleukin-9. (142 aa)
	TBP	TATA-box-binding protein. (322 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	IL22	Interleukin-22 isoform X1. (179 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	RPL13A	A0A2U3X7R0	A0A2U3Z0Q1	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	60S ribosomal protein L13a isoform X1; Belongs to the universal ribosomal protein uL13 family.	0.424
B2M	TBP	A0A2U3X7R0	A0A2U3YLV1	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	TATA-box-binding protein.	0.492
GATA3	IFNG	A0A2U3YCA3	A0A2U3Y8N2	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.733
GATA3	IL10	A0A2U3YCA3	A0A2U3XRS9	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	Interleukin-10.	0.641
GATA3	IL13	A0A2U3YCA3	A0A2U3XTH0	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	Interleukin-13.	0.704
GATA3	IL22	A0A2U3YCA3	A0A2U3Y8K1	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	Interleukin-22 isoform X1.	0.569
GATA3	IL4	A0A2U3YCA3	A0A2U3XTG1	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.722
GATA3	IL6	A0A2U3YCA3	A0A2U3YGL7	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	Interleukin-6 isoform X1.	0.540
GATA3	IL9	A0A2U3YCA3	A0A2U3YLZ0	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	Interleukin-9.	0.499
GATA3	TBP	A0A2U3YCA3	A0A2U3YLV1	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	TATA-box-binding protein.	0.546
IFNG	GATA3	A0A2U3Y8N2	A0A2U3YCA3	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.733
IFNG	IL10	A0A2U3Y8N2	A0A2U3XRS9	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-10.	0.962
IFNG	IL13	A0A2U3Y8N2	A0A2U3XTH0	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-13.	0.856
IFNG	IL22	A0A2U3Y8N2	A0A2U3Y8K1	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-22 isoform X1.	0.786
IFNG	IL4	A0A2U3Y8N2	A0A2U3XTG1	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.887
IFNG	IL6	A0A2U3Y8N2	A0A2U3YGL7	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-6 isoform X1.	0.931
IFNG	IL9	A0A2U3Y8N2	A0A2U3YLZ0	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-9.	0.700
IL10	GATA3	A0A2U3XRS9	A0A2U3YCA3	Interleukin-10.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.641
IL10	IFNG	A0A2U3XRS9	A0A2U3Y8N2	Interleukin-10.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.962
IL10	IL13	A0A2U3XRS9	A0A2U3XTH0	Interleukin-10.	Interleukin-13.	0.869