(8 nodes) (2017) Synovitis in osteoarthritis: current understanding with therapeutic implications. network (Leptonychotes weddellii)

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Your Input:
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	IL10	Interleukin-10. (178 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (131 aa)
	IL13	Interleukin-13. (133 aa)
	CD4	T-cell surface glycoprotein CD4. (462 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	CXCL13	c-X-C motif chemokine 13. (110 aa)
	ICAM1	Intercellular adhesion molecule 1. (533 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	CXCL13	A0A2U3Y2Q1	A0A2U3YIF7	T-cell surface glycoprotein CD4.	c-X-C motif chemokine 13.	0.505
CD4	ICAM1	A0A2U3Y2Q1	A0A2U3YSH4	T-cell surface glycoprotein CD4.	Intercellular adhesion molecule 1.	0.707
CD4	IL10	A0A2U3Y2Q1	A0A2U3XRS9	T-cell surface glycoprotein CD4.	Interleukin-10.	0.883
CD4	IL13	A0A2U3Y2Q1	A0A2U3XTH0	T-cell surface glycoprotein CD4.	Interleukin-13.	0.814
CD4	IL18	A0A2U3Y2Q1	A0A2U3XPG8	T-cell surface glycoprotein CD4.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.651
CD4	IL4	A0A2U3Y2Q1	A0A2U3XTG1	T-cell surface glycoprotein CD4.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.854
CD4	IL6	A0A2U3Y2Q1	A0A2U3YGL7	T-cell surface glycoprotein CD4.	Interleukin-6 isoform X1.	0.876
CXCL13	CD4	A0A2U3YIF7	A0A2U3Y2Q1	c-X-C motif chemokine 13.	T-cell surface glycoprotein CD4.	0.505
CXCL13	IL10	A0A2U3YIF7	A0A2U3XRS9	c-X-C motif chemokine 13.	Interleukin-10.	0.508
CXCL13	IL4	A0A2U3YIF7	A0A2U3XTG1	c-X-C motif chemokine 13.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.493
CXCL13	IL6	A0A2U3YIF7	A0A2U3YGL7	c-X-C motif chemokine 13.	Interleukin-6 isoform X1.	0.676
ICAM1	CD4	A0A2U3YSH4	A0A2U3Y2Q1	Intercellular adhesion molecule 1.	T-cell surface glycoprotein CD4.	0.707
ICAM1	IL10	A0A2U3YSH4	A0A2U3XRS9	Intercellular adhesion molecule 1.	Interleukin-10.	0.630
ICAM1	IL13	A0A2U3YSH4	A0A2U3XTH0	Intercellular adhesion molecule 1.	Interleukin-13.	0.489
ICAM1	IL18	A0A2U3YSH4	A0A2U3XPG8	Intercellular adhesion molecule 1.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.491
ICAM1	IL4	A0A2U3YSH4	A0A2U3XTG1	Intercellular adhesion molecule 1.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.539
ICAM1	IL6	A0A2U3YSH4	A0A2U3YGL7	Intercellular adhesion molecule 1.	Interleukin-6 isoform X1.	0.774
IL10	CD4	A0A2U3XRS9	A0A2U3Y2Q1	Interleukin-10.	T-cell surface glycoprotein CD4.	0.883
IL10	CXCL13	A0A2U3XRS9	A0A2U3YIF7	Interleukin-10.	c-X-C motif chemokine 13.	0.508
IL10	ICAM1	A0A2U3XRS9	A0A2U3YSH4	Interleukin-10.	Intercellular adhesion molecule 1.	0.630