(23 nodes) (2020) Dendritic cells and Brucella spp. interaction: the sentinel host and the stealthy pathogen. network (Leptonychotes weddellii)

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Your Input:
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	IRAK4	Interleukin-1 receptor-associated kinase 4 isoform X1. (459 aa)
	CD80	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80. (295 aa)
	TLR6	Toll-like receptor. (794 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
	IL10	Interleukin-10. (178 aa)
	IRF4	Interferon regulatory factor 4 isoform X1. (451 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (131 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
	IL13	Interleukin-13. (133 aa)
	CD83	CD83 antigen isoform X1. (199 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	CD4	T-cell surface glycoprotein CD4. (462 aa)
	CD40	Tumor necrosis factor receptor superfamily member 5. (272 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	CD1C	T-cell surface glycoprotein CD1c. (337 aa)
	STAT2	Signal transducer and activator of transcription. (854 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	IRF8	Interferon regulatory factor 8. (426 aa)
	CCR7	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (390 aa)
	IL17A	interleukin-17A. (155 aa)
	CSF2	Granulocyte-macrophage colony-stimulating factor. (153 aa)
	TLR5	LOW QUALITY PROTEIN: toll-like receptor 5; Belongs to the Toll-like receptor family. (834 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCR7	CD4	A0A2U3YRB2	A0A2U3Y2Q1	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	T-cell surface glycoprotein CD4.	0.806
CCR7	CD40	A0A2U3YRB2	A0A2U3Y7Z8	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Tumor necrosis factor receptor superfamily member 5.	0.693
CCR7	CD80	A0A2U3YRB2	A0A2U3XGM7	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	0.766
CCR7	CD83	A0A2U3YRB2	A0A2U3XYN6	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	CD83 antigen isoform X1.	0.679
CCR7	CSF2	A0A2U3YRB2	A0A2U3Z5Z5	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Granulocyte-macrophage colony-stimulating factor.	0.601
CCR7	IFNG	A0A2U3YRB2	A0A2U3Y8N2	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.710
CCR7	IL10	A0A2U3YRB2	A0A2U3XRS9	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin-10.	0.632
CCR7	IL13	A0A2U3YRB2	A0A2U3XTH0	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin-13.	0.489
CCR7	IL17A	A0A2U3YRB2	A0A2U3YYK4	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	interleukin-17A.	0.507
CCR7	IL4	A0A2U3YRB2	A0A2U3XTG1	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.614
CCR7	IL5	A0A2U3YRB2	A0A2U3XTG3	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells.	0.451
CCR7	IL6	A0A2U3YRB2	A0A2U3YGL7	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Interleukin-6 isoform X1.	0.664
CCR7	IRF4	A0A2U3YRB2	A0A2U3XSN5	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Interferon regulatory factor 4 isoform X1.	0.505
CCR7	IRF8	A0A2U3YRB2	A0A2U3YJQ6	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	Interferon regulatory factor 8.	0.426
CD1C	CD4	A0A2U3YB36	A0A2U3Y2Q1	T-cell surface glycoprotein CD1c.	T-cell surface glycoprotein CD4.	0.424
CD4	CCR7	A0A2U3Y2Q1	A0A2U3YRB2	T-cell surface glycoprotein CD4.	c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family.	0.806
CD4	CD1C	A0A2U3Y2Q1	A0A2U3YB36	T-cell surface glycoprotein CD4.	T-cell surface glycoprotein CD1c.	0.424
CD4	CD40	A0A2U3Y2Q1	A0A2U3Y7Z8	T-cell surface glycoprotein CD4.	Tumor necrosis factor receptor superfamily member 5.	0.804
CD4	CD80	A0A2U3Y2Q1	A0A2U3XGM7	T-cell surface glycoprotein CD4.	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	0.831
CD4	CD83	A0A2U3Y2Q1	A0A2U3XYN6	T-cell surface glycoprotein CD4.	CD83 antigen isoform X1.	0.630