(13 nodes) (2019) Mechanisms of MTH1 inhibition-induced DNA strand breaks: The slippery slope from the oxidized nucleotide pool to genotoxic damage. network (Leptonychotes weddellii)

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Your Input:
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	KRAS	GTPase KRas isoform X2. (188 aa)
	NRAS	GTPase NRas. (189 aa)
	NEIL3	Endonuclease 8-like 3. (651 aa)
	MUTYH	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (519 aa)
	PRDX1	Peroxiredoxin-1. (199 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
	ABCB1	Multidrug resistance protein 1. (1280 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	OGG1	N-glycosylase/DNA lyase isoform X2. (334 aa)
	NTHL1	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (314 aa)
	NEIL1	Endonuclease 8-like 1. (383 aa)
	CTLA4	Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAV1	CAV2	A0A2U3XCN0	A0A2U3XC92	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.999
CAV1	CAV3	A0A2U3XCN0	A0A2U3XYT3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.952
CAV1	NRAS	A0A2U3XCN0	A0A2U3XAI8	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	GTPase NRas.	0.552
CAV2	CAV1	A0A2U3XC92	A0A2U3XCN0	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.999
CAV2	CAV3	A0A2U3XC92	A0A2U3XYT3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.991
CAV3	CAV1	A0A2U3XYT3	A0A2U3XCN0	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.952
CAV3	CAV2	A0A2U3XYT3	A0A2U3XC92	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.991
KRAS	NRAS	A0A2U3X8L4	A0A2U3XAI8	GTPase KRas isoform X2.	GTPase NRas.	0.898
MUTYH	NEIL1	A0A2U3XC60	A0A2U3YLP3	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	Endonuclease 8-like 1.	0.699
MUTYH	NEIL3	A0A2U3XC60	A0A2U3XAT2	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	Endonuclease 8-like 3.	0.770
MUTYH	NTHL1	A0A2U3XC60	A0A2U3YE14	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.891
MUTYH	OGG1	A0A2U3XC60	A0A2U3Y5R8	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	N-glycosylase/DNA lyase isoform X2.	0.951
NEIL1	MUTYH	A0A2U3YLP3	A0A2U3XC60	Endonuclease 8-like 1.	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	0.699
NEIL1	NEIL3	A0A2U3YLP3	A0A2U3XAT2	Endonuclease 8-like 1.	Endonuclease 8-like 3.	0.814
NEIL1	NTHL1	A0A2U3YLP3	A0A2U3YE14	Endonuclease 8-like 1.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.739
NEIL1	OGG1	A0A2U3YLP3	A0A2U3Y5R8	Endonuclease 8-like 1.	N-glycosylase/DNA lyase isoform X2.	0.917
NEIL3	MUTYH	A0A2U3XAT2	A0A2U3XC60	Endonuclease 8-like 3.	Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs.	0.770
NEIL3	NEIL1	A0A2U3XAT2	A0A2U3YLP3	Endonuclease 8-like 3.	Endonuclease 8-like 1.	0.814
NEIL3	NTHL1	A0A2U3XAT2	A0A2U3YE14	Endonuclease 8-like 3.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.	0.910
NEIL3	OGG1	A0A2U3XAT2	A0A2U3Y5R8	Endonuclease 8-like 3.	N-glycosylase/DNA lyase isoform X2.	0.868