(17 nodes) (2020) Next-Generation Sequencing Analysis of Cellular Response to Influenza B Virus Infection. network (Leptonychotes weddellii)

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Your Input:
	ISG15	Ubiquitin-like protein ISG15. (169 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
	TNFAIP3	Tumor necrosis factor alpha-induced protein 3. (790 aa)
	CDC25C	M-phase inducer phosphatase 3 isoform X1. (473 aa)
	JAK2	Tyrosine-protein kinase. (952 aa)
	C1R	Complement C1r subcomponent isoform X1; Belongs to the peptidase S1 family. (705 aa)
	PSME2	Proteasome activator complex subunit 2 isoform X1. (239 aa)
	IRF9	Interferon regulatory factor 9 isoform X1. (445 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	CDK4	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
	MX1	Interferon-induced GTP-binding protein Mx1. (291 aa)
	STAT2	Signal transducer and activator of transcription. (854 aa)
	IRF7	Interferon regulatory factor 7. (470 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (547 aa)
	AMBRA1	Activating molecule in BECN1-regulated autophagy protein 1-like. (299 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC25C	CDK4	A0A2U3Y0L5	A0A2U3Y8P9	M-phase inducer phosphatase 3 isoform X1.	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.	0.724
CDK4	CDC25C	A0A2U3Y8P9	A0A2U3Y0L5	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.	M-phase inducer phosphatase 3 isoform X1.	0.724
CDK4	JAK2	A0A2U3Y8P9	A0A2U3Y110	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.464
CSF1	CXCL10	A0A2U3YQ02	A0A2U3YK42	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	C-X-C motif chemokine.	0.619
CSF1	IFNG	A0A2U3YQ02	A0A2U3Y8N2	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.699
CSF1	MYD88	A0A2U3YQ02	A0A2U3Z302	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.510
CXCL10	CSF1	A0A2U3YK42	A0A2U3YQ02	C-X-C motif chemokine.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.619
CXCL10	IFNG	A0A2U3YK42	A0A2U3Y8N2	C-X-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.853
CXCL10	IRF7	A0A2U3YK42	A0A2U3YDR6	C-X-C motif chemokine.	Interferon regulatory factor 7.	0.680
CXCL10	IRF9	A0A2U3YK42	A0A2U3Y4T8	C-X-C motif chemokine.	Interferon regulatory factor 9 isoform X1.	0.547
CXCL10	ISG15	A0A2U3YK42	A0A2U3XMC4	C-X-C motif chemokine.	Ubiquitin-like protein ISG15.	0.914
CXCL10	MX1	A0A2U3YK42	A0A2U3YB15	C-X-C motif chemokine.	Interferon-induced GTP-binding protein Mx1.	0.681
CXCL10	MYD88	A0A2U3YK42	A0A2U3Z302	C-X-C motif chemokine.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.555
CXCL10	STAT2	A0A2U3YK42	A0A2U3YBI2	C-X-C motif chemokine.	Signal transducer and activator of transcription.	0.506
CXCL10	TLR7	A0A2U3YK42	A0A2U3XPX3	C-X-C motif chemokine.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.497
CXCL10	TNFAIP3	A0A2U3YK42	A0A2U3XU44	C-X-C motif chemokine.	Tumor necrosis factor alpha-induced protein 3.	0.487
IFNG	CSF1	A0A2U3Y8N2	A0A2U3YQ02	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.699
IFNG	CXCL10	A0A2U3Y8N2	A0A2U3YK42	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	C-X-C motif chemokine.	0.853
IFNG	IRF7	A0A2U3Y8N2	A0A2U3YDR6	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interferon regulatory factor 7.	0.574
IFNG	IRF9	A0A2U3Y8N2	A0A2U3Y4T8	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interferon regulatory factor 9 isoform X1.	0.561