(77 nodes) (2021) Genome Instability in Multiple Myeloma: Facts and Factors. network (Leptonychotes weddellii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	KRAS	GTPase KRas isoform X2. (188 aa)
	ATRX	Transcriptional regulator ATRX isoform X1. (2489 aa)
	TET2	Methylcytosine dioxygenase TET2 isoform X2. (2016 aa)
	ZFHX4	Zinc finger homeobox protein 4. (3602 aa)
	MCL1	Induced myeloid leukemia cell differentiation protein Mcl-1 homolog isoform X1. (350 aa)
	SETDB1	Histone-lysine N-methyltransferase SETDB1 isoform X1. (1297 aa)
	PSMD4	26S proteasome non-ATPase regulatory subunit 4. (377 aa)
	NRAS	GTPase NRas. (189 aa)
	ERCC4	DNA repair endonuclease XPF. (916 aa)
	BRCA2	Breast cancer type 2 susceptibility protein homolog. (2818 aa)
	PAX5	Paired box protein Pax-5 isoform X1. (362 aa)
	CCND3	G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (291 aa)
	IGJ	Immunoglobulin J chain isoform X1. (158 aa)
	KPNA2	Importin subunit alpha; Functions in nuclear protein import. (529 aa)
	FOXO3	Forkhead box protein O3. (672 aa)
	BMI1	Polycomb complex protein BMI-1 isoform X1. (326 aa)
	EP300	Histone acetyltransferase p300. (2425 aa)
	USP45	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (816 aa)
	DDB1	DNA damage-binding protein 1. (431 aa)
	CDKN2C	Cyclin-dependent kinase 4 inhibitor C. (168 aa)
	NFKBIA	NF-kappa-B inhibitor alpha isoform X2. (314 aa)
	DNMT3A	DNA (Cytosine-5)-methyltransferase 3A; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (835 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor 1B. (198 aa)
	XPO1	Exportin-1. (384 aa)
	IDH1	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
	SALL4	Sal-like protein 4. (1052 aa)
	IRF4	Interferon regulatory factor 4 isoform X1. (451 aa)
	MEIS2	Homeobox protein Meis2-like isoform X5. (464 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	LOC102748968	40S ribosomal protein S3a; May play a role during erythropoiesis through regulation of transcription factor DDIT3. (264 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	NCOR1	Nuclear receptor corepressor 1 isoform X1. (2435 aa)
	KLF2	Krueppel-like factor 2. (150 aa)
	FGFR3	Fibroblast growth factor receptor. (809 aa)
	RAG1	V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
	KDM3B	Lysine-specific demethylase 3B-like. (1410 aa)
	BCL6	B-cell lymphoma 6 protein. (706 aa)
	ULK4	Serine/threonine-protein kinase ULK4 isoform X1. (1274 aa)
	CHD4	chromodomain-helicase-DNA-binding protein 4 isoform X2. (1912 aa)
	PSMB8	Proteasome subunit beta. (276 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	EHMT2	Histone-lysine N-methyltransferase EHMT2 isoform X1. (1268 aa)
	ERCC1	DNA excision repair protein ERCC-1. (293 aa)
	ARID2	AT-rich interactive domain-containing protein 2. (1836 aa)
	FANCD2	Fanconi anemia group D2 protein. (511 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (255 aa)
	ARID1A	AT-rich interactive domain-containing protein 1A. (1630 aa)
	CDK4	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
	DIS3	Exosome complex exonuclease RRP44 isoform X1; Belongs to the RNR ribonuclease family. (958 aa)
	LIG4	DNA ligase. (911 aa)
	SMARCD3	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3. (435 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	CEP120	Centrosomal protein of 120 kDa. (910 aa)
	SLAMF1	Signaling lymphocytic activation molecule. (312 aa)
	PSMG2	Proteasome assembly chaperone 2; Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. Belongs to the PSMG2 family. (266 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
	SLAMF7	SLAM family member 7 isoform X1. (338 aa)
	CCND1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
	IDH2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
	TXNDC5	Thioredoxin domain-containing protein 5; Belongs to the protein disulfide isomerase family. (323 aa)
	TOM1	Target of Myb protein 1; Belongs to the TOM1 family. (492 aa)
	TOP2A	DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1514 aa)
	PSMB5	Proteasome subunit beta type-5. (160 aa)
	JARID2	Protein Jumonji. (1075 aa)
	ILF2	Interleukin enhancer-binding factor 2. (234 aa)
	LOC102747537	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (549 aa)
	ANP32E	Acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X1. (265 aa)
	SP3	Transcription factor Sp3-like. (751 aa)
	NF1	Neurofibromin-like. (1269 aa)
	STAT3	Signal transducer and activator of transcription 3-like. (424 aa)
	RNF40	E3 ubiquitin protein ligase; Belongs to the BRE1 family. (962 aa)
	LOC102726384	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (390 aa)
	NFKB2	Nuclear factor NF-kappa-B p100 subunit. (900 aa)
	PAPOLB	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (641 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANP32E	PCNA	A0A2U3YY70	A0A2U3XVX8	Acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X1.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.501
ANP32E	XPO1	A0A2U3YY70	A0A2U3XP75	Acidic leucine-rich nuclear phosphoprotein 32 family member E isoform X1.	Exportin-1.	0.909
ARID1A	ARID2	A0A2U3Y7N3	A0A2U3Y4W0	AT-rich interactive domain-containing protein 1A.	AT-rich interactive domain-containing protein 2.	0.606
ARID1A	ATM	A0A2U3Y7N3	A0A2U3YJR1	AT-rich interactive domain-containing protein 1A.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.461
ARID1A	BRCA2	A0A2U3Y7N3	A0A2U3XC46	AT-rich interactive domain-containing protein 1A.	Breast cancer type 2 susceptibility protein homolog.	0.479
ARID1A	CCND1	A0A2U3Y7N3	A0A2U3YLX0	AT-rich interactive domain-containing protein 1A.	G1/S-specific cyclin-D1; Belongs to the cyclin family.	0.434
ARID1A	CDK4	A0A2U3Y7N3	A0A2U3Y8P9	AT-rich interactive domain-containing protein 1A.	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.	0.532
ARID1A	DNMT3A	A0A2U3Y7N3	A0A2U3XNL4	AT-rich interactive domain-containing protein 1A.	DNA (Cytosine-5)-methyltransferase 3A; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.	0.424
ARID1A	EP300	A0A2U3Y7N3	A0A2U3XF65	AT-rich interactive domain-containing protein 1A.	Histone acetyltransferase p300.	0.937
ARID1A	KDM3B	A0A2U3Y7N3	A0A2U3Y0S6	AT-rich interactive domain-containing protein 1A.	Lysine-specific demethylase 3B-like.	0.813
ARID1A	KRAS	A0A2U3Y7N3	A0A2U3X8L4	AT-rich interactive domain-containing protein 1A.	GTPase KRas isoform X2.	0.545
ARID1A	LOC102747537	A0A2U3Y7N3	A0A2U3YY69	AT-rich interactive domain-containing protein 1A.	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...]	0.438
ARID1A	NCOR1	A0A2U3Y7N3	A0A2U3XXC7	AT-rich interactive domain-containing protein 1A.	Nuclear receptor corepressor 1 isoform X1.	0.604
ARID1A	SMARCD3	A0A2U3Y7N3	A0A2U3YG79	AT-rich interactive domain-containing protein 1A.	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3.	0.992
ARID2	ARID1A	A0A2U3Y4W0	A0A2U3Y7N3	AT-rich interactive domain-containing protein 2.	AT-rich interactive domain-containing protein 1A.	0.606
ARID2	ATRX	A0A2U3Y4W0	A0A2U3X662	AT-rich interactive domain-containing protein 2.	Transcriptional regulator ATRX isoform X1.	0.509
ARID2	NF1	A0A2U3Y4W0	A0A2U3Z255	AT-rich interactive domain-containing protein 2.	Neurofibromin-like.	0.440
ARID2	SMARCD3	A0A2U3Y4W0	A0A2U3YG79	AT-rich interactive domain-containing protein 2.	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3.	0.981
ATG5	FOXO3	A0A2U3Y6R5	A0A2U3XDW8	Autophagy protein 5; Involved in autophagic vesicle formation.	Forkhead box protein O3.	0.460
ATG5	IL1B	A0A2U3Y6R5	A0A2U3YM52	Autophagy protein 5; Involved in autophagic vesicle formation.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.489