(18 nodes) (2022) RANKL biology. network (Leptonychotes weddellii)

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Your Input:
	CD40	Tumor necrosis factor receptor superfamily member 5. (272 aa)
	GPR4	G-protein coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	CD4	T-cell surface glycoprotein CD4. (462 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (131 aa)
	IL10	Interleukin-10. (178 aa)
	CD80	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80. (295 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (261 aa)
	LGR4	Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
	CCL20	C-C motif chemokine. (89 aa)
	TNFRSF11B	Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	CTLA4	Cytotoxic T-lymphocyte protein 4 isoform X1. (223 aa)
	CSF1	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (547 aa)
	FOXP3	Forkhead box protein P3 isoform X1. (456 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL20	CD4	A0A2U3Z480	A0A2U3Y2Q1	C-C motif chemokine.	T-cell surface glycoprotein CD4.	0.541
CCL20	CD40	A0A2U3Z480	A0A2U3Y7Z8	C-C motif chemokine.	Tumor necrosis factor receptor superfamily member 5.	0.419
CCL20	CD80	A0A2U3Z480	A0A2U3XGM7	C-C motif chemokine.	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	0.548
CCL20	CSF1	A0A2U3Z480	A0A2U3YQ02	C-C motif chemokine.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.475
CCL20	FOXP3	A0A2U3Z480	A0A2U3YH69	C-C motif chemokine.	Forkhead box protein P3 isoform X1.	0.473
CCL20	IFNG	A0A2U3Z480	A0A2U3Y8N2	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.580
CCL20	IL10	A0A2U3Z480	A0A2U3XRS9	C-C motif chemokine.	Interleukin-10.	0.551
CCL20	IL4	A0A2U3Z480	A0A2U3XTG1	C-C motif chemokine.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.516
CCL20	IL6	A0A2U3Z480	A0A2U3YGL7	C-C motif chemokine.	Interleukin-6 isoform X1.	0.752
CD4	CCL20	A0A2U3Y2Q1	A0A2U3Z480	T-cell surface glycoprotein CD4.	C-C motif chemokine.	0.541
CD4	CD40	A0A2U3Y2Q1	A0A2U3Y7Z8	T-cell surface glycoprotein CD4.	Tumor necrosis factor receptor superfamily member 5.	0.804
CD4	CD80	A0A2U3Y2Q1	A0A2U3XGM7	T-cell surface glycoprotein CD4.	LOW QUALITY PROTEIN: T-lymphocyte activation antigen CD80.	0.831
CD4	CSF1	A0A2U3Y2Q1	A0A2U3YQ02	T-cell surface glycoprotein CD4.	Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...]	0.531
CD4	CTLA4	A0A2U3Y2Q1	A0A2U3YTN6	T-cell surface glycoprotein CD4.	Cytotoxic T-lymphocyte protein 4 isoform X1.	0.814
CD4	FOXP3	A0A2U3Y2Q1	A0A2U3YH69	T-cell surface glycoprotein CD4.	Forkhead box protein P3 isoform X1.	0.849
CD4	IFNG	A0A2U3Y2Q1	A0A2U3Y8N2	T-cell surface glycoprotein CD4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.891
CD4	IL10	A0A2U3Y2Q1	A0A2U3XRS9	T-cell surface glycoprotein CD4.	Interleukin-10.	0.883
CD4	IL4	A0A2U3Y2Q1	A0A2U3XTG1	T-cell surface glycoprotein CD4.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.854
CD4	IL6	A0A2U3Y2Q1	A0A2U3YGL7	T-cell surface glycoprotein CD4.	Interleukin-6 isoform X1.	0.876
CD4	TRAF6	A0A2U3Y2Q1	A0A2U3XYU7	T-cell surface glycoprotein CD4.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.492