(12 nodes) (2022) Lonicera caerulea Berry Polyphenols Extract Alleviates Exercise Fatigue in Mice by Reducing Oxidative Stress, Inflammation, Skeletal Muscle Cell Apoptosis, and by Increasing Cell Proliferation. network (Leptonychotes weddellii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APAF1	Apoptotic protease-activating factor 1. (511 aa)
	IGF1R	Insulin-like growth factor 1 receptor-like. (291 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	TFAM	Transcription factor A, mitochondrial isoform X1. (246 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (302 aa)
	LOC102732330	Histone H3; Belongs to the histone H3 family. (136 aa)
	MYOG	Myogenin. (224 aa)
	CASP9	Caspase-9. (171 aa)
	LOC102730819	Histone H3; Belongs to the histone H3 family. (136 aa)
	LOC102745013	Histone H3; Belongs to the histone H3 family. (136 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	LOC102737083	Histone H3; Belongs to the histone H3 family. (136 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	CASP3	A0A2U3XFH1	A0A2U3YM46	Apoptotic protease-activating factor 1.	Caspase-3; Belongs to the peptidase C14A family.	0.993
APAF1	CASP9	A0A2U3XFH1	A0A2U3YZ30	Apoptotic protease-activating factor 1.	Caspase-9.	0.995
CASP3	APAF1	A0A2U3YM46	A0A2U3XFH1	Caspase-3; Belongs to the peptidase C14A family.	Apoptotic protease-activating factor 1.	0.993
CASP3	CASP9	A0A2U3YM46	A0A2U3YZ30	Caspase-3; Belongs to the peptidase C14A family.	Caspase-9.	0.981
CASP3	IGF1R	A0A2U3YM46	A0A2U3Y3Q9	Caspase-3; Belongs to the peptidase C14A family.	Insulin-like growth factor 1 receptor-like.	0.469
CASP3	IL6	A0A2U3YM46	A0A2U3YGL7	Caspase-3; Belongs to the peptidase C14A family.	Interleukin-6 isoform X1.	0.750
CASP3	LOC102730819	A0A2U3YM46	A0A2U3Z299	Caspase-3; Belongs to the peptidase C14A family.	Histone H3; Belongs to the histone H3 family.	0.659
CASP3	LOC102732330	A0A2U3YM46	A0A2U3YTU8	Caspase-3; Belongs to the peptidase C14A family.	Histone H3; Belongs to the histone H3 family.	0.659
CASP3	LOC102737083	A0A2U3YM46	A0A2U3XZD0	Caspase-3; Belongs to the peptidase C14A family.	Histone H3; Belongs to the histone H3 family.	0.701
CASP3	LOC102745013	A0A2U3YM46	A0A2U3Z2M3	Caspase-3; Belongs to the peptidase C14A family.	Histone H3; Belongs to the histone H3 family.	0.701
CASP3	MTOR	A0A2U3YM46	A0A2U3XVT2	Caspase-3; Belongs to the peptidase C14A family.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.569
CASP3	MYOG	A0A2U3YM46	A0A2U3XJX0	Caspase-3; Belongs to the peptidase C14A family.	Myogenin.	0.402
CASP3	TFAM	A0A2U3YM46	A0A2U3YKW2	Caspase-3; Belongs to the peptidase C14A family.	Transcription factor A, mitochondrial isoform X1.	0.465
CASP9	APAF1	A0A2U3YZ30	A0A2U3XFH1	Caspase-9.	Apoptotic protease-activating factor 1.	0.995
CASP9	CASP3	A0A2U3YZ30	A0A2U3YM46	Caspase-9.	Caspase-3; Belongs to the peptidase C14A family.	0.981
CASP9	IL6	A0A2U3YZ30	A0A2U3YGL7	Caspase-9.	Interleukin-6 isoform X1.	0.551
IGF1R	CASP3	A0A2U3Y3Q9	A0A2U3YM46	Insulin-like growth factor 1 receptor-like.	Caspase-3; Belongs to the peptidase C14A family.	0.469
IL6	CASP3	A0A2U3YGL7	A0A2U3YM46	Interleukin-6 isoform X1.	Caspase-3; Belongs to the peptidase C14A family.	0.750
IL6	CASP9	A0A2U3YGL7	A0A2U3YZ30	Interleukin-6 isoform X1.	Caspase-9.	0.551
IL6	MTOR	A0A2U3YGL7	A0A2U3XVT2	Interleukin-6 isoform X1.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.474