(21 nodes) (2022) Ferroptosis and its emerging roles in acute pancreatitis. network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GCH1	GTP cyclohydrolase 1. (249 aa)
	CHMP5	Charged multivesicular body protein 5. (232 aa)
	NUPR1	Nuclear protein 1 isoform X1. (82 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
	TCF4	Transcription factor 4. (401 aa)
	LOC102743896	Thioredoxin; Belongs to the thioredoxin family. (121 aa)
	HAMP	Hepcidin. (83 aa)
	TPD52	Tumor protein D52 isoform X1. (245 aa)
	SLC7A1	High affinity cationic amino acid transporter 1. (229 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
	COQ2	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (369 aa)
	ARNTL	Aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X5. (583 aa)
	EGLN2	Egl nine homolog 2-like. (405 aa)
	TXN	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	NOX1	NADPH oxidase 1 isoform X1. (564 aa)
	RAB7A	Ras-related protein Rab-7a isoform X1. (207 aa)
	CALCOCO2	Calcium-binding and coiled-coil domain-containing protein 2 isoform X2. (449 aa)
	KEAP1	Kelch-like ECH-associated protein 1. (624 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (255 aa)
	LPCAT3	Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family. (487 aa)
	ACSL4	long-chain-fatty-acid--CoA ligase 4. (711 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSL4	LPCAT3	A0A2U3Y0N2	A0A2U3Y2I0	long-chain-fatty-acid--CoA ligase 4.	Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family.	0.769
ATG5	CALCOCO2	A0A2U3Y6R5	A0A2U3YCR1	Autophagy protein 5; Involved in autophagic vesicle formation.	Calcium-binding and coiled-coil domain-containing protein 2 isoform X2.	0.537
ATG5	INS	A0A2U3Y6R5	A0A2U3Z329	Autophagy protein 5; Involved in autophagic vesicle formation.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.485
ATG5	KEAP1	A0A2U3Y6R5	A0A2U3YBM1	Autophagy protein 5; Involved in autophagic vesicle formation.	Kelch-like ECH-associated protein 1.	0.535
CALCOCO2	ATG5	A0A2U3YCR1	A0A2U3Y6R5	Calcium-binding and coiled-coil domain-containing protein 2 isoform X2.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.537
GCH1	SOD2	A0A2U3XYK9	A0A2U3XPI1	GTP cyclohydrolase 1.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.479
INS	ATG5	A0A2U3Z329	A0A2U3Y6R5	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.485
INS	KEAP1	A0A2U3Z329	A0A2U3YBM1	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Kelch-like ECH-associated protein 1.	0.451
INS	LOC102743896	A0A2U3Z329	A0A2U3XJV3	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Thioredoxin; Belongs to the thioredoxin family.	0.526
INS	SOD2	A0A2U3Z329	A0A2U3XPI1	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.470
INS	TXN	A0A2U3Z329	A0A2U3YK60	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Thioredoxin; Belongs to the thioredoxin family.	0.646
KEAP1	ATG5	A0A2U3YBM1	A0A2U3Y6R5	Kelch-like ECH-associated protein 1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.535
KEAP1	INS	A0A2U3YBM1	A0A2U3Z329	Kelch-like ECH-associated protein 1.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.451
KEAP1	SOD2	A0A2U3YBM1	A0A2U3XPI1	Kelch-like ECH-associated protein 1.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.539
KEAP1	TXN	A0A2U3YBM1	A0A2U3YK60	Kelch-like ECH-associated protein 1.	Thioredoxin; Belongs to the thioredoxin family.	0.571
LOC102743896	INS	A0A2U3XJV3	A0A2U3Z329	Thioredoxin; Belongs to the thioredoxin family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.526
LOC102743896	TXN	A0A2U3XJV3	A0A2U3YK60	Thioredoxin; Belongs to the thioredoxin family.	Thioredoxin; Belongs to the thioredoxin family.	0.713
LPCAT3	ACSL4	A0A2U3Y2I0	A0A2U3Y0N2	Lysophospholipid acyltransferase 5; Belongs to the membrane-bound acyltransferase family.	long-chain-fatty-acid--CoA ligase 4.	0.769
SOD2	GCH1	A0A2U3XPI1	A0A2U3XYK9	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	GTP cyclohydrolase 1.	0.479
SOD2	INS	A0A2U3XPI1	A0A2U3Z329	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.470