(11 nodes) (2022) Many roads lead to CASM: Diverse stimuli of noncanonical autophagy share a unifying molecular mechanism. network (Leptonychotes weddellii)

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Your Input:
	ATG4D	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (330 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (255 aa)
	ATP6V0C	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (155 aa)
	GABARAP	Gamma-aminobutyric acid receptor-associated protein. (117 aa)
	TMEM203	Transmembrane protein 203. (136 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	TFEB	Transcription factor EB. (329 aa)
	FLCN	Folliculin. (579 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (261 aa)
	UVRAG	UV radiation resistance-associated gene protein. (697 aa)
	IL10RB	Interleukin-10 receptor subunit beta. (375 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG4D	A0A2U3XZP0	A0A2U3YBY7	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.673
ATG12	ATG5	A0A2U3XZP0	A0A2U3Y6R5	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	GABARAP	A0A2U3XZP0	A0A2U3Y5T4	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Gamma-aminobutyric acid receptor-associated protein.	0.942
ATG12	TFEB	A0A2U3XZP0	A0A2U3XD63	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Transcription factor EB.	0.472
ATG12	UVRAG	A0A2U3XZP0	A0A2U3YI88	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	UV radiation resistance-associated gene protein.	0.668
ATG4D	ATG12	A0A2U3YBY7	A0A2U3XZP0	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.673
ATG4D	ATG5	A0A2U3YBY7	A0A2U3Y6R5	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.671
ATG4D	GABARAP	A0A2U3YBY7	A0A2U3Y5T4	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	Gamma-aminobutyric acid receptor-associated protein.	0.949
ATG5	ATG12	A0A2U3Y6R5	A0A2U3XZP0	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	ATG4D	A0A2U3Y6R5	A0A2U3YBY7	Autophagy protein 5; Involved in autophagic vesicle formation.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.671
ATG5	GABARAP	A0A2U3Y6R5	A0A2U3Y5T4	Autophagy protein 5; Involved in autophagic vesicle formation.	Gamma-aminobutyric acid receptor-associated protein.	0.917
ATG5	TFEB	A0A2U3Y6R5	A0A2U3XD63	Autophagy protein 5; Involved in autophagic vesicle formation.	Transcription factor EB.	0.637
ATG5	UVRAG	A0A2U3Y6R5	A0A2U3YI88	Autophagy protein 5; Involved in autophagic vesicle formation.	UV radiation resistance-associated gene protein.	0.693
ATP6V0C	FLCN	A0A2U3Y6K0	A0A2U3YLS2	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	Folliculin.	0.567
FLCN	ATP6V0C	A0A2U3YLS2	A0A2U3Y6K0	Folliculin.	V-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.	0.567
FLCN	TFEB	A0A2U3YLS2	A0A2U3XD63	Folliculin.	Transcription factor EB.	0.480
GABARAP	ATG12	A0A2U3Y5T4	A0A2U3XZP0	Gamma-aminobutyric acid receptor-associated protein.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.942
GABARAP	ATG4D	A0A2U3Y5T4	A0A2U3YBY7	Gamma-aminobutyric acid receptor-associated protein.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.949
GABARAP	ATG5	A0A2U3Y5T4	A0A2U3Y6R5	Gamma-aminobutyric acid receptor-associated protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.917
GABARAP	UVRAG	A0A2U3Y5T4	A0A2U3YI88	Gamma-aminobutyric acid receptor-associated protein.	UV radiation resistance-associated gene protein.	0.660