node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MTOR | PPARA | A0A2U3XVT2 | A0A2U3Z257 | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | Peroxisome proliferator-activated receptor alpha. | 0.657 |
MTOR | TP53 | A0A2U3XVT2 | A0A2U3Y5G3 | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.782 |
MTOR | TP73 | A0A2U3XVT2 | A0A2U3YWX9 | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | 0.575 |
NFE2L2 | TP53 | A0A2U3YSZ9 | A0A2U3Y5G3 | Nuclear factor erythroid 2-related factor 2 isoform X1. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.430 |
NFKB1 | TP53 | A0A2U3XMD9 | A0A2U3Y5G3 | Nuclear factor NF-kappa-B p105 subunit. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.545 |
PGR | TP53 | A0A2U3XGQ6 | A0A2U3Y5G3 | Progesterone receptor. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.649 |
PPARA | MTOR | A0A2U3Z257 | A0A2U3XVT2 | Peroxisome proliferator-activated receptor alpha. | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 0.657 |
PPARA | PPARD | A0A2U3Z257 | A0A2U3Y0F9 | Peroxisome proliferator-activated receptor alpha. | Peroxisome proliferator-activated receptor delta isoform X1. | 0.403 |
PPARD | PPARA | A0A2U3Y0F9 | A0A2U3Z257 | Peroxisome proliferator-activated receptor delta isoform X1. | Peroxisome proliferator-activated receptor alpha. | 0.403 |
TP53 | MTOR | A0A2U3Y5G3 | A0A2U3XVT2 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 0.782 |
TP53 | NFE2L2 | A0A2U3Y5G3 | A0A2U3YSZ9 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Nuclear factor erythroid 2-related factor 2 isoform X1. | 0.430 |
TP53 | NFKB1 | A0A2U3Y5G3 | A0A2U3XMD9 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Nuclear factor NF-kappa-B p105 subunit. | 0.545 |
TP53 | PGR | A0A2U3Y5G3 | A0A2U3XGQ6 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Progesterone receptor. | 0.649 |
TP53 | TP73 | A0A2U3Y5G3 | A0A2U3YWX9 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | 0.917 |
TP73 | MTOR | A0A2U3YWX9 | A0A2U3XVT2 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. | 0.575 |
TP73 | TP53 | A0A2U3YWX9 | A0A2U3Y5G3 | Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.917 |