STRINGSTRING
PPARA PPARA PPARD PPARD TP53 TP53 RHO RHO NPAS1 NPAS1 NFE2L2 NFE2L2 NR1I3 NR1I3 CD47 CD47 TP73 TP73 CD300A CD300A PGR PGR NFKB1 NFKB1 MTOR MTOR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPARAPeroxisome proliferator-activated receptor alpha. (303 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
RHORhodopsin. (348 aa)
NPAS1Neuronal PAS domain-containing protein 1 isoform X1. (593 aa)
NFE2L2Nuclear factor erythroid 2-related factor 2 isoform X1. (590 aa)
NR1I3Nuclear receptor subfamily 1 group I member 3 isoform X1. (348 aa)
CD47Leukocyte surface antigen CD47. (317 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
CD300ACMRF35-like molecule 8. (309 aa)
PGRProgesterone receptor. (827 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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