STRINGSTRING
SUMO2 SUMO2 DNA2 DNA2 BRCA2 BRCA2 PALB2 PALB2 AXIN1 AXIN1 GEN1 GEN1 HDAC1 HDAC1 FOXL2 FOXL2 SUMO1 SUMO1 RAD50 RAD50 RAD51C RAD51C LOC102726286 LOC102726286 LOC102746084 LOC102746084 LOC102737083 LOC102737083 EPCAM EPCAM CDC25C CDC25C CHD4 CHD4 NANOG NANOG ERCC1 ERCC1 SIRT6 SIRT6 HDAC5 HDAC5 SIRT2 SIRT2 LOC102737595 LOC102737595 HDAC8 HDAC8 EME1 EME1 HDAC4 HDAC4 SIRT3 SIRT3 SIRT7 SIRT7 HDAC2 HDAC2 CASP3 CASP3 SUMO3 SUMO3 LOC102732330 LOC102732330 EXO1 EXO1 ENDOG ENDOG LOC102730819 LOC102730819 LOC102745013 LOC102745013 IGF2 IGF2 HDAC3 HDAC3 ATRIP ATRIP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SUMO2Small ubiquitin-related modifier. (95 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1061 aa)
BRCA2Breast cancer type 2 susceptibility protein homolog. (2818 aa)
PALB2Partner and localizer of BRCA2. (1183 aa)
AXIN1Axin-1 isoform X1. (867 aa)
GEN1Flap endonuclease GEN homolog 1. (907 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
FOXL2Forkhead box protein L2. (257 aa)
SUMO1Small ubiquitin-related modifier. (101 aa)
RAD50DNA repair protein RAD50. (973 aa)
RAD51CDNA repair protein RAD51 homolog 3-like. (371 aa)
LOC102726286Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (78 aa)
LOC102746084Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC102737083Histone H3; Belongs to the histone H3 family. (136 aa)
EPCAMEpithelial cell adhesion molecule. (316 aa)
CDC25CM-phase inducer phosphatase 3 isoform X1. (473 aa)
CHD4chromodomain-helicase-DNA-binding protein 4 isoform X2. (1912 aa)
NANOGHomeobox protein NANOG. (226 aa)
ERCC1DNA excision repair protein ERCC-1. (293 aa)
SIRT6NAD-dependent protein deacetylase sirtuin-6. (359 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1116 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
LOC102737595Small ubiquitin-related modifier. (95 aa)
HDAC8Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (415 aa)
EME1Crossover junction endonuclease EME1 isoform X1. (579 aa)
HDAC4Histone deacetylase 4-like. (667 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (373 aa)
SIRT7NAD-dependent protein deacetylase sirtuin-7. (251 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
SUMO3Small ubiquitin-related modifier. (111 aa)
LOC102732330Histone H3; Belongs to the histone H3 family. (136 aa)
EXO1LOW QUALITY PROTEIN: exonuclease 1. (793 aa)
ENDOGEndonuclease. (342 aa)
LOC102730819Histone H3; Belongs to the histone H3 family. (136 aa)
LOC102745013Histone H3; Belongs to the histone H3 family. (136 aa)
IGF2Insulin-like growth factor II. (138 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
ATRIPATR-interacting protein. (597 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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