(14 nodes) (2022) Innate Immune System Activation, Inflammation and Corneal Wound Healing. network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PFN3	Profilin; Belongs to the profilin family. (137 aa)
	TLR6	Toll-like receptor. (794 aa)
	HBEGF	Proheparin-binding EGF-like growth factor. (208 aa)
	TLR5	LOW QUALITY PROTEIN: toll-like receptor 5; Belongs to the Toll-like receptor family. (834 aa)
	PFN4	Profilin; Belongs to the profilin family. (129 aa)
	CXCL10	C-X-C motif chemokine. (98 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	NOD2	Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
	MMP9	Matrix metalloproteinase-9. (704 aa)
	AQP3	Aquaporin-3; Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
	IL10	Interleukin-10. (178 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)
	IL18	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
	PFN2	Profilin; Belongs to the profilin family. (140 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CXCL10	IL10	A0A2U3YK42	A0A2U3XRS9	C-X-C motif chemokine.	Interleukin-10.	0.904
CXCL10	IL18	A0A2U3YK42	A0A2U3XPG8	C-X-C motif chemokine.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.706
CXCL10	IL6	A0A2U3YK42	A0A2U3YGL7	C-X-C motif chemokine.	Interleukin-6 isoform X1.	0.803
CXCL10	MMP9	A0A2U3YK42	A0A2U3Y7X3	C-X-C motif chemokine.	Matrix metalloproteinase-9.	0.586
CXCL10	TLR6	A0A2U3YK42	A0A2U3XLL7	C-X-C motif chemokine.	Toll-like receptor.	0.701
CXCL10	TLR7	A0A2U3YK42	A0A2U3XPX3	C-X-C motif chemokine.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.497
HBEGF	MMP9	A0A2U3XJ45	A0A2U3Y7X3	Proheparin-binding EGF-like growth factor.	Matrix metalloproteinase-9.	0.939
IL10	CXCL10	A0A2U3XRS9	A0A2U3YK42	Interleukin-10.	C-X-C motif chemokine.	0.904
IL10	IL18	A0A2U3XRS9	A0A2U3XPG8	Interleukin-10.	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	0.822
IL10	IL6	A0A2U3XRS9	A0A2U3YGL7	Interleukin-10.	Interleukin-6 isoform X1.	0.988
IL10	MMP9	A0A2U3XRS9	A0A2U3Y7X3	Interleukin-10.	Matrix metalloproteinase-9.	0.710
IL10	NOD2	A0A2U3XRS9	A0A2U3YF51	Interleukin-10.	Nucleotide-binding oligomerization domain-containing protein 2.	0.546
IL10	TLR5	A0A2U3XRS9	A0A2U3Z9N0	Interleukin-10.	LOW QUALITY PROTEIN: toll-like receptor 5; Belongs to the Toll-like receptor family.	0.574
IL10	TLR6	A0A2U3XRS9	A0A2U3XLL7	Interleukin-10.	Toll-like receptor.	0.840
IL10	TLR7	A0A2U3XRS9	A0A2U3XPX3	Interleukin-10.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.608
IL18	CXCL10	A0A2U3XPG8	A0A2U3YK42	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	C-X-C motif chemokine.	0.706
IL18	IL10	A0A2U3XPG8	A0A2U3XRS9	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin-10.	0.822
IL18	IL6	A0A2U3XPG8	A0A2U3YGL7	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Interleukin-6 isoform X1.	0.817
IL18	MMP9	A0A2U3XPG8	A0A2U3Y7X3	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Matrix metalloproteinase-9.	0.467
IL18	NOD2	A0A2U3XPG8	A0A2U3YF51	Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family.	Nucleotide-binding oligomerization domain-containing protein 2.	0.577