(17 nodes) (2022) Dual targeting of mTORIL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation. network (Leptonychotes weddellii)

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Your Input:
	CCL20	C-C motif chemokine. (89 aa)
	IL17A	interleukin-17A. (155 aa)
	IL31	Interleukin-31. (185 aa)
	DEPTOR	DEP domain-containing mTOR-interacting protein. (305 aa)
	IL9	Interleukin-9. (142 aa)
	IL6	Interleukin-6 isoform X1. (212 aa)
	RICTOR	Rapamycin-insensitive companion of mTOR isoform X1. (1732 aa)
	ULK2	Serine/threonine-protein kinase ULK2. (1036 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	IL22	Interleukin-22 isoform X1. (179 aa)
	ATG9A	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (743 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (255 aa)
	CD4	T-cell surface glycoprotein CD4. (462 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (131 aa)
	IL10	Interleukin-10. (178 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1050 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG12	ATG5	A0A2U3XZP0	A0A2U3Y6R5	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG12	ATG9A	A0A2U3XZP0	A0A2U3Y7P8	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.739
ATG12	ULK2	A0A2U3XZP0	A0A2U3YGE0	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	Serine/threonine-protein kinase ULK2.	0.982
ATG5	ATG12	A0A2U3Y6R5	A0A2U3XZP0	Autophagy protein 5; Involved in autophagic vesicle formation.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.999
ATG5	ATG9A	A0A2U3Y6R5	A0A2U3Y7P8	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.683
ATG5	IFNG	A0A2U3Y6R5	A0A2U3Y8N2	Autophagy protein 5; Involved in autophagic vesicle formation.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.401
ATG5	IL6	A0A2U3Y6R5	A0A2U3YGL7	Autophagy protein 5; Involved in autophagic vesicle formation.	Interleukin-6 isoform X1.	0.473
ATG5	ULK2	A0A2U3Y6R5	A0A2U3YGE0	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase ULK2.	0.932
ATG9A	ATG12	A0A2U3Y7P8	A0A2U3XZP0	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.739
ATG9A	ATG5	A0A2U3Y7P8	A0A2U3Y6R5	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.683
ATG9A	ULK2	A0A2U3Y7P8	A0A2U3YGE0	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	Serine/threonine-protein kinase ULK2.	0.960
CCL20	CD4	A0A2U3Z480	A0A2U3Y2Q1	C-C motif chemokine.	T-cell surface glycoprotein CD4.	0.541
CCL20	IFNG	A0A2U3Z480	A0A2U3Y8N2	C-C motif chemokine.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.580
CCL20	IL10	A0A2U3Z480	A0A2U3XRS9	C-C motif chemokine.	Interleukin-10.	0.551
CCL20	IL17A	A0A2U3Z480	A0A2U3YYK4	C-C motif chemokine.	interleukin-17A.	0.601
CCL20	IL22	A0A2U3Z480	A0A2U3Y8K1	C-C motif chemokine.	Interleukin-22 isoform X1.	0.594
CCL20	IL4	A0A2U3Z480	A0A2U3XTG1	C-C motif chemokine.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.516
CCL20	IL6	A0A2U3Z480	A0A2U3YGL7	C-C motif chemokine.	Interleukin-6 isoform X1.	0.752
CD4	CCL20	A0A2U3Y2Q1	A0A2U3Z480	T-cell surface glycoprotein CD4.	C-C motif chemokine.	0.541
CD4	IFNG	A0A2U3Y2Q1	A0A2U3Y8N2	T-cell surface glycoprotein CD4.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.891