(14 nodes) (2023) Oxidative Stress-Involved Mitophagy of Retinal Pigment Epithelium and Retinal Degenerative Diseases. network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SRC	Tyrosine-protein kinase. (536 aa)
	PINK1	Serine/threonine-protein kinase PINK1, mitochondrial. (488 aa)
	GABARAP	Gamma-aminobutyric acid receptor-associated protein. (117 aa)
	KEAP1	Kelch-like ECH-associated protein 1. (624 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (373 aa)
	TXN	Thioredoxin; Belongs to the thioredoxin family. (105 aa)
	NBR1	Next to BRCA1 gene 1 protein. (948 aa)
	ENDOG	Endonuclease. (342 aa)
	FOXO3	Forkhead box protein O3. (672 aa)
	TXNIP	Thioredoxin-interacting protein-like. (391 aa)
	LOC102743896	Thioredoxin; Belongs to the thioredoxin family. (121 aa)
	PTEN	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
	TAX1BP1	Tax1-binding protein 1 homolog isoform X1. (686 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FOXO3	PINK1	A0A2U3XDW8	A0A2U3Y3N8	Forkhead box protein O3.	Serine/threonine-protein kinase PINK1, mitochondrial.	0.444
FOXO3	PTEN	A0A2U3XDW8	A0A2U3XMX7	Forkhead box protein O3.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.715
FOXO3	SIRT3	A0A2U3XDW8	A0A2U3YDN3	Forkhead box protein O3.	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.	0.959
FOXO3	SOD2	A0A2U3XDW8	A0A2U3XPI1	Forkhead box protein O3.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.642
FOXO3	TXN	A0A2U3XDW8	A0A2U3YK60	Forkhead box protein O3.	Thioredoxin; Belongs to the thioredoxin family.	0.445
GABARAP	NBR1	A0A2U3Y5T4	A0A2U3Z4C3	Gamma-aminobutyric acid receptor-associated protein.	Next to BRCA1 gene 1 protein.	0.999
GABARAP	PINK1	A0A2U3Y5T4	A0A2U3Y3N8	Gamma-aminobutyric acid receptor-associated protein.	Serine/threonine-protein kinase PINK1, mitochondrial.	0.421
GABARAP	TAX1BP1	A0A2U3Y5T4	A0A2U3XNM7	Gamma-aminobutyric acid receptor-associated protein.	Tax1-binding protein 1 homolog isoform X1.	0.843
KEAP1	NBR1	A0A2U3YBM1	A0A2U3Z4C3	Kelch-like ECH-associated protein 1.	Next to BRCA1 gene 1 protein.	0.695
KEAP1	SOD2	A0A2U3YBM1	A0A2U3XPI1	Kelch-like ECH-associated protein 1.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.539
KEAP1	TXN	A0A2U3YBM1	A0A2U3YK60	Kelch-like ECH-associated protein 1.	Thioredoxin; Belongs to the thioredoxin family.	0.571
LOC102743896	TXN	A0A2U3XJV3	A0A2U3YK60	Thioredoxin; Belongs to the thioredoxin family.	Thioredoxin; Belongs to the thioredoxin family.	0.713
LOC102743896	TXNIP	A0A2U3XJV3	A0A2U3XFE4	Thioredoxin; Belongs to the thioredoxin family.	Thioredoxin-interacting protein-like.	0.516
NBR1	GABARAP	A0A2U3Z4C3	A0A2U3Y5T4	Next to BRCA1 gene 1 protein.	Gamma-aminobutyric acid receptor-associated protein.	0.999
NBR1	KEAP1	A0A2U3Z4C3	A0A2U3YBM1	Next to BRCA1 gene 1 protein.	Kelch-like ECH-associated protein 1.	0.695
NBR1	PINK1	A0A2U3Z4C3	A0A2U3Y3N8	Next to BRCA1 gene 1 protein.	Serine/threonine-protein kinase PINK1, mitochondrial.	0.823
NBR1	TAX1BP1	A0A2U3Z4C3	A0A2U3XNM7	Next to BRCA1 gene 1 protein.	Tax1-binding protein 1 homolog isoform X1.	0.751
PINK1	FOXO3	A0A2U3Y3N8	A0A2U3XDW8	Serine/threonine-protein kinase PINK1, mitochondrial.	Forkhead box protein O3.	0.444
PINK1	GABARAP	A0A2U3Y3N8	A0A2U3Y5T4	Serine/threonine-protein kinase PINK1, mitochondrial.	Gamma-aminobutyric acid receptor-associated protein.	0.421
PINK1	NBR1	A0A2U3Y3N8	A0A2U3Z4C3	Serine/threonine-protein kinase PINK1, mitochondrial.	Next to BRCA1 gene 1 protein.	0.823