(30 nodes) Transforming growth factor-beta (TGF-beta) family network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	INHBC	Inhibin beta C chain. (352 aa)
	INHBE	Inhibin beta E chain. (351 aa)
	LOC102731762	Bone morphogenetic protein 15-like. (393 aa)
	MSTN	Growth/differentiation factor 8. (375 aa)
	LOC102737253	Glial cell line-derived neurotrophic factor-like isoform X1. (211 aa)
	BMP5	Bone morphogenetic protein 5 isoform X2. (454 aa)
	GDF11	Growth/differentiation factor 11. (372 aa)
	GDF9	Growth/differentiation factor 9. (453 aa)
	INHBB	Inhibin beta B chain. (320 aa)
	BMP3	Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
	BMP8B	Bone morphogenetic protein 8B. (169 aa)
	GDF3	Growth/differentiation factor 3. (365 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
	LEFTY1	Left-right determination factor. (366 aa)
	LOC102745999	Left-right determination factor 1-like. (203 aa)
	BMP7	Bone morphogenetic protein 7-like. (312 aa)
	BMP6	Bone morphogenetic protein 6. (189 aa)
	NODAL	Nodal homolog. (348 aa)
	GDF15	Growth/differentiation factor 15. (308 aa)
	GDF5	Growth/differentiation factor 5. (499 aa)
	INHBA	Inhibin beta A chain. (424 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	GDF1	Embryonic growth/differentiation factor 1. (227 aa)
	LOC102745526	Neurturin-like. (191 aa)
	LOC102749531	Growth/differentiation factor 2-like. (260 aa)
	GDF10	Bone morphogenetic protein 3; Belongs to the TGF-beta family. (371 aa)
	LOC102740547	Bone morphogenetic protein 4-like isoform X1. (409 aa)
	PSPN	Persephin. (146 aa)
	INHA	Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
	BMP2	Bone morphogenetic protein 2-like. (395 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP5	A0A2U3Z3S1	A0A2U3XA39	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 5 isoform X2.	0.497
BMP2	BMP6	A0A2U3Z3S1	A0A2U3YPC2	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 6.	0.924
BMP2	BMP7	A0A2U3Z3S1	A0A2U3YG58	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 7-like.	0.592
BMP2	BMP8B	A0A2U3Z3S1	A0A2U3Y1R3	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 8B.	0.488
BMP2	GDF5	A0A2U3Z3S1	A0A2U3YTC5	Bone morphogenetic protein 2-like.	Growth/differentiation factor 5.	0.598
BMP2	LOC102740547	A0A2U3Z3S1	A0A2U3Z034	Bone morphogenetic protein 2-like.	Bone morphogenetic protein 4-like isoform X1.	0.898
BMP2	NODAL	A0A2U3Z3S1	A0A2U3YPZ3	Bone morphogenetic protein 2-like.	Nodal homolog.	0.407
BMP2	TGFB2	A0A2U3Z3S1	A0A2U3Y3M9	Bone morphogenetic protein 2-like.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.414
BMP5	BMP2	A0A2U3XA39	A0A2U3Z3S1	Bone morphogenetic protein 5 isoform X2.	Bone morphogenetic protein 2-like.	0.497
BMP5	LOC102740547	A0A2U3XA39	A0A2U3Z034	Bone morphogenetic protein 5 isoform X2.	Bone morphogenetic protein 4-like isoform X1.	0.650
BMP6	BMP2	A0A2U3YPC2	A0A2U3Z3S1	Bone morphogenetic protein 6.	Bone morphogenetic protein 2-like.	0.924
BMP6	LOC102740547	A0A2U3YPC2	A0A2U3Z034	Bone morphogenetic protein 6.	Bone morphogenetic protein 4-like isoform X1.	0.944
BMP7	BMP2	A0A2U3YG58	A0A2U3Z3S1	Bone morphogenetic protein 7-like.	Bone morphogenetic protein 2-like.	0.592
BMP7	GDF5	A0A2U3YG58	A0A2U3YTC5	Bone morphogenetic protein 7-like.	Growth/differentiation factor 5.	0.437
BMP7	LOC102740547	A0A2U3YG58	A0A2U3Z034	Bone morphogenetic protein 7-like.	Bone morphogenetic protein 4-like isoform X1.	0.734
BMP8B	BMP2	A0A2U3Y1R3	A0A2U3Z3S1	Bone morphogenetic protein 8B.	Bone morphogenetic protein 2-like.	0.488
BMP8B	LOC102740547	A0A2U3Y1R3	A0A2U3Z034	Bone morphogenetic protein 8B.	Bone morphogenetic protein 4-like isoform X1.	0.488
GDF1	NODAL	A0A2U3YYE2	A0A2U3YPZ3	Embryonic growth/differentiation factor 1.	Nodal homolog.	0.628
GDF3	NODAL	A0A2U3Y3K6	A0A2U3YPZ3	Growth/differentiation factor 3.	Nodal homolog.	0.659
GDF5	BMP2	A0A2U3YTC5	A0A2U3Z3S1	Growth/differentiation factor 5.	Bone morphogenetic protein 2-like.	0.598