STRINGSTRING
LOC102751021 LOC102751021 HGF HGF PDGFC PDGFC BCL2L1 BCL2L1 KRAS KRAS LOC102726446 LOC102726446 TGFA TGFA NRAS NRAS CSDE1 CSDE1 ERBB3 ERBB3 PIK3R3 PIK3R3 LOC102742552 LOC102742552 FOXO3 FOXO3 LOC102730129 LOC102730129 MAP2K1 MAP2K1 IGF1 IGF1 PTEN PTEN LOC102729427 LOC102729427 EIF4E1B EIF4E1B SRC SRC NRG1 NRG1 SHC1 SHC1 GAB1 GAB1 MTOR MTOR FGFR3 FGFR3 SHC4 SHC4 CEP152 CEP152 JAK2 JAK2 IGF1R IGF1R AKT1 AKT1 ERAS ERAS LOC102745161 LOC102745161 GAS6 GAS6 MAP2K2 MAP2K2 FGFR2 FGFR2 LOC102749673 LOC102749673 AKT3 AKT3 RAF1 RAF1 RPS6KB1 RPS6KB1 GSK3B GSK3B IL6 IL6 LOC102746004 LOC102746004 MAPK1 MAPK1 LOC102735415 LOC102735415 LOC102726827 LOC102726827 PIK3CD PIK3CD PIK3CA PIK3CA PDGFB PDGFB LOC102737030 LOC102737030 LOC102736516 LOC102736516 PDGFRA PDGFRA AXL AXL LOC102731850 LOC102731850 LOC102740057 LOC102740057 EIF4E2 EIF4E2 NF1 NF1 FGF2 FGF2 LOC102729504 LOC102729504 STAT3 STAT3 RPS6KB2 RPS6KB2 LOC102749847 LOC102749847
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (730 aa)
PDGFCPlatelet-derived growth factor C-like; Belongs to the PDGF/VEGF growth factor family. (345 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
KRASGTPase KRas isoform X2. (188 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
TGFAProtransforming growth factor alpha. (160 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1339 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
LOC102742552Platelet-derived growth factor D-like isoform X1. (370 aa)
FOXO3Forkhead box protein O3. (672 aa)
LOC102730129Uncharacterized protein LOC102730129. (471 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LOC10272942740S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (215 aa)
SRCTyrosine-protein kinase. (536 aa)
NRG1Pro-neuregulin-3, membrane-bound isoform-like isoform X1. (694 aa)
SHC1SHC-transforming protein 1 isoform X2. (583 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
FGFR3Fibroblast growth factor receptor. (809 aa)
SHC4SHC-transforming protein 4. (630 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
JAK2Tyrosine-protein kinase. (952 aa)
IGF1RInsulin-like growth factor 1 receptor-like. (291 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
ERASGTPase ERas. (233 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
GAS6Growth arrest-specific protein 6. (646 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
FGFR2Fibroblast growth factor receptor 2. (658 aa)
LOC102749673Insulin-like growth factor 1 receptor-like. (143 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
RPS6KB1Non-specific serine/threonine protein kinase. (445 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
IL6Interleukin-6 isoform X1. (212 aa)
LOC102746004Bcl-2-like protein 11-like isoform X2. (140 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
LOC102726827Eukaryotic translation initiation factor 4E-like; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
LOC102737030Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. (627 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
AXLTyrosine-protein kinase receptor UFO. (887 aa)
LOC102731850Tyrosine-protein kinase receptor. (757 aa)
LOC102740057Vascular endothelial growth factor A-like isoform X1; Belongs to the PDGF/VEGF growth factor family. (186 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2; Belongs to the eukaryotic initiation factor 4E family. (192 aa)
NF1Neurofibromin-like. (1269 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (113 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
LOC102749847Tyrosine-protein kinase JAK1-like. (444 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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