STRINGSTRING
MAPK11 MAPK11 KRAS KRAS LOC102726446 LOC102726446 NRAS NRAS CSDE1 CSDE1 PIK3R3 PIK3R3 ADCY6 ADCY6 MAPK10 MAPK10 LOC102751021 LOC102751021 MAP2K1 MAP2K1 IGF1 IGF1 HBEGF HBEGF CDKN2C CDKN2C CDKN1B CDKN1B SRC SRC SHC1 SHC1 MAPK12 MAPK12 LOC102745454 LOC102745454 MTOR MTOR NCOR1 NCOR1 GPSM3 GPSM3 NOTCH4 NOTCH4 SHC4 SHC4 CEP152 CEP152 PRKACB PRKACB JAG1 JAG1 E2F2 E2F2 MAPK8 MAPK8 IGF1R IGF1R AKT1 AKT1 ERAS ERAS MAP2K2 MAP2K2 TP53 TP53 JUN JUN MMP9 MMP9 LOC102749673 LOC102749673 AKT3 AKT3 CDK4 CDK4 MDM2 MDM2 RAF1 RAF1 RPS6KB1 RPS6KB1 RB1 RB1 PTRHD1 PTRHD1 SP1 SP1 DLL4 DLL4 LOC102742813 LOC102742813 MAPK1 MAPK1 NCOA3 NCOA3 ADCY9 ADCY9 DLL1 DLL1 CCND1 CCND1 LOC102746012 LOC102746012 PIK3CD PIK3CD FOS FOS PIK3CA PIK3CA LOC102737030 LOC102737030 MED1 MED1 LOC102736516 LOC102736516 ESR2 ESR2 E2F3 E2F3 NOTCH2 NOTCH2 GPER1 GPER1 LOC102731850 LOC102731850 LOC102729504 LOC102729504 CDKN1A CDKN1A LOC102735556 LOC102735556 RPS6KB2 RPS6KB2 PRKACA PRKACA LOC102731038 LOC102731038
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK11Mitogen-activated protein kinase. (254 aa)
KRASGTPase KRas isoform X2. (188 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
SRCTyrosine-protein kinase. (536 aa)
SHC1SHC-transforming protein 1 isoform X2. (583 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
LOC102745454Nuclear receptor coactivator 3-like. (176 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
NCOR1Nuclear receptor corepressor 1 isoform X1. (2435 aa)
GPSM3G-protein-signaling modulator 3 isoform X1. (162 aa)
NOTCH4Neurogenic locus notch homolog protein 4 isoform X1. (1996 aa)
SHC4SHC-transforming protein 4. (630 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
E2F2Transcription factor E2F2. (440 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IGF1RInsulin-like growth factor 1 receptor-like. (291 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
ERASGTPase ERas. (233 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
MMP9Matrix metalloproteinase-9. (704 aa)
LOC102749673Insulin-like growth factor 1 receptor-like. (143 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
RPS6KB1Non-specific serine/threonine protein kinase. (445 aa)
RB1Retinoblastoma-associated protein. (846 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
SP1Transcription factor Sp1 isoform X1. (786 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
LOC102742813Neuroendocrine secretory protein 55-like. (246 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
NCOA3Nuclear receptor coactivator 3-like. (1154 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC102737030Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. (627 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
ESR2Estrogen receptor beta. (429 aa)
E2F3Transcription factor E2F3-like isoform X1. (465 aa)
NOTCH2Neurogenic locus notch homolog protein 2. (1238 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
LOC102731850Tyrosine-protein kinase receptor. (757 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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