STRINGSTRING
GSTO1 GSTO1 LOC102734861 LOC102734861 LOC102751021 LOC102751021 BIRC5 BIRC5 LOC102737868 LOC102737868 LOC102736146 LOC102736146 CDKN1A CDKN1A LOC102739775 LOC102739775 LOC102729504 LOC102729504 BIRC2 BIRC2 CASP8 CASP8 POLH POLH CASP9 CASP9 LOC102726062 LOC102726062 MSH3 MSH3 LOC102738241 LOC102738241 BIRC3 BIRC3 LOC102736516 LOC102736516 LOC102737030 LOC102737030 TOP2A TOP2A LOC102740820 LOC102740820 LOC102740522 LOC102740522 PIK3CA PIK3CA LOC102725545 LOC102725545 PIK3CD PIK3CD CASP3 CASP3 ATM ATM LOC102730785 LOC102730785 MAPK1 MAPK1 MGST2 MGST2 GSTM3 GSTM3 XPA XPA GSTM1 GSTM1 XIAP XIAP MGST3 MGST3 ATP7B ATP7B MDM2 MDM2 AKT3 AKT3 TP53 TP53 MGST1 MGST1 ERCC1 ERCC1 AKT1 AKT1 BAK1 BAK1 FASLG FASLG MSH2 MSH2 FADD FADD MSH6 MSH6 LOC102750923 LOC102750923 REV3L REV3L SLC31A1 SLC31A1 LOC102745146 LOC102745146 LOC102725978 LOC102725978 PMAIP1 PMAIP1 APAF1 APAF1 PIK3R3 PIK3R3 LOC102726446 LOC102726446 BCL2L1 BCL2L1 ATP7A ATP7A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GSTO1Glutathione S-transferase omega-1 isoform X1; Belongs to the GST superfamily. (241 aa)
LOC102734861BH3-interacting domain death agonist-like. (83 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (74 aa)
LOC102737868Canalicular multispecific organic anion transporter 1-like. (280 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
LOC102739775Breast cancer type 1 susceptibility protein homolog. (471 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
BIRC2Baculoviral IAP repeat-containing protein 2-like. (619 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
POLHDNA polymerase eta isoform X1. (712 aa)
CASP9Caspase-9. (171 aa)
LOC102726062Uncharacterized protein C7orf31 homolog. (590 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1126 aa)
LOC102738241Mitogen-activated protein kinase kinase kinase 5-like. (795 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
LOC102737030Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. (627 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1514 aa)
LOC102740820Glutathione S-transferase theta-1-like; Belongs to the GST superfamily. (240 aa)
LOC102740522Glutathione S-transferase theta-1-like; Belongs to the GST superfamily. (242 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC102725545Caspase-9-like; Belongs to the peptidase C14A family. (275 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
LOC102730785Glutathione S-transferase P-like; Belongs to the GST superfamily. (210 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
MGST2Microsomal glutathione S-transferase 2. (146 aa)
GSTM3Glutathione S-transferase. (226 aa)
XPADNA repair protein complementing XP-A cells. (273 aa)
GSTM1Glutathione S-transferase Mu 1 isoform X1. (218 aa)
XIAPE3 ubiquitin-protein ligase XIAP-like isoform X1. (497 aa)
MGST3Microsomal glutathione S-transferase 3 isoform X1. (152 aa)
ATP7BCopper-transporting ATPase 2. (1432 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
MGST1Microsomal glutathione S-transferase 1 isoform X2. (155 aa)
ERCC1DNA excision repair protein ERCC-1. (293 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
FASLGTumor necrosis factor ligand superfamily member 6. (130 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (951 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1362 aa)
LOC102750923Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
REV3LDNA polymerase zeta catalytic subunit. (3024 aa)
SLC31A1High affinity copper uptake protein 1. (178 aa)
LOC102745146Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (173 aa)
LOC102725978Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (109 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
APAF1Apoptotic protease-activating factor 1. (511 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
ATP7ACopper-transporting ATPase 1 isoform X1. (1498 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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