STRINGSTRING
MSL1 MSL1 DDX25 DDX25 NEDD1 NEDD1 LOC102732031 LOC102732031 PPP2R2A PPP2R2A PPP2R5D PPP2R5D RBMX2 RBMX2 FIP1L1 FIP1L1 PABPN1L PABPN1L RNGTT RNGTT PABPC1L2A PABPC1L2A LOC102743069 LOC102743069 LOC102728921 LOC102728921 LOC102741366 LOC102741366 CPSF3L CPSF3L POLDIP3 POLDIP3 PPP2CB PPP2CB PELO PELO DDX39A DDX39A TMEM258 TMEM258 NXF1 NXF1 TMEM223 TMEM223 TUT1 TUT1 TWF1 TWF1 LOC102730310 LOC102730310 FUS FUS MKRN3 MKRN3 YTHDC1 YTHDC1 SMG7 SMG7 WIBG WIBG DCLRE1B DCLRE1B CLP1 CLP1 RNF141 RNF141 LOC102730695 LOC102730695 BOLL BOLL PABPC5 PABPC5 PPP2R3A PPP2R3A LOC102750290 LOC102750290 LOC102728564 LOC102728564 DUSP11 DUSP11 LOC102734435 LOC102734435 LOC102729790 LOC102729790 LOC102726351 LOC102726351 NUDT21 NUDT21 DDX19B DDX19B LOC102741335 LOC102741335 CPSF4 CPSF4 FNBP4 FNBP4 UPF1 UPF1 PPP2R3B PPP2R3B PCF11 PCF11 PPP1CA PPP1CA LOC102736431 LOC102736431 MAGOH MAGOH LOC102742356 LOC102742356 LOC102729615 LOC102729615 SMG6 SMG6 LOC102730629 LOC102730629 LOC102741653 LOC102741653 LOC102726384 LOC102726384 PAPOLB PAPOLB LOC102739075 LOC102739075 RBM8A RBM8A SRRM1 SRRM1 LOC102744119 LOC102744119 LOC102751025 LOC102751025 MKRN1 MKRN1 COPS5 COPS5 PABPC4 PABPC4 CPSF4L CPSF4L LOC102736167 LOC102736167 NXT2 NXT2 ZC3H8 ZC3H8 CPSF3 CPSF3 NXF2B NXF2B HBS1L HBS1L LOC102748768 LOC102748768 RBM3 RBM3 DDX39B DDX39B SERAC1 SERAC1 RNPS1 RNPS1 LOC102725708 LOC102725708 PPP2R5C PPP2R5C CSTF3 CSTF3 PPP1CC PPP1CC MKRN2 MKRN2 CSTF1 CSTF1 CIRBP CIRBP CPSF2 CPSF2 WDR33 WDR33 UPF3B UPF3B PPP1CB PPP1CB PPP4R1 PPP4R1 PARP11 PARP11 NCBP2 NCBP2 NXT1 NXT1 DCLRE1A DCLRE1A PPP2R2C PPP2R2C CPSF6 CPSF6 PPP2R5A PPP2R5A CSTF2 CSTF2 PIH1D3 PIH1D3 RNMT RNMT PPP2R5E PPP2R5E LOC102738520 LOC102738520
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MSL1Male-specific lethal 1 homolog isoform X1. (614 aa)
DDX25ATP-dependent RNA helicase DDX25. (465 aa)
NEDD1Protein NEDD1-like isoform X1. (659 aa)
LOC102732031Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (407 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (676 aa)
RBMX2RNA-binding motif protein, X-linked 2. (323 aa)
FIP1L1pre-mRNA 3'-end-processing factor FIP1 isoform X1. (594 aa)
PABPN1LLOW QUALITY PROTEIN: embryonic polyadenylate-binding protein 2. (299 aa)
RNGTTPolynucleotide 5'-triphosphatase; Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus. (568 aa)
PABPC1L2APolyadenylate-binding protein 1-like 2. (200 aa)
LOC102743069Histone deacetylase complex subunit SAP18; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or durin [...] (153 aa)
LOC102728921Juxtaposed with another zinc finger protein 1-like. (218 aa)
LOC102741366Methylosome protein 50-like. (169 aa)
CPSF3LIntegrator complex subunit 11 isoform X1. (600 aa)
POLDIP3Polymerase delta-interacting protein 3. (378 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
DDX39AATP-dependent RNA helicase DDX39A. (427 aa)
TMEM258Transmembrane protein 258. (79 aa)
NXF1Nuclear RNA export factor 1. (618 aa)
TMEM223Transmembrane protein 223. (196 aa)
TUT1Speckle targeted PIP5K1A-regulated poly(A) polymerase. (871 aa)
TWF1Twinfilin-1 isoform X2. (357 aa)
LOC102730310Pinin-like. (509 aa)
FUSRNA-binding protein FUS isoform X1. (517 aa)
MKRN3Probable E3 ubiquitin-protein ligase makorin-3. (501 aa)
YTHDC1YTH domain-containing protein 1 isoform X1. (730 aa)
SMG7Protein SMG7 isoform X1. (1169 aa)
WIBGPartner of Y14 and mago. (203 aa)
DCLRE1B5' exonuclease Apollo. (538 aa)
CLP1Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (425 aa)
RNF141RING finger protein 141. (230 aa)
LOC102730695Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (227 aa)
BOLLProtein boule-like isoform X1. (293 aa)
PABPC5Polyadenylate-binding protein 5. (382 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1. (1153 aa)
LOC102750290Polyadenylate-binding protein 1-like. (311 aa)
LOC102728564Polyadenylate-binding protein 4-like. (370 aa)
DUSP11RNA/RNP complex-1-interacting phosphatase. (332 aa)
LOC102734435Regulator of nonsense transcripts 2-like. (121 aa)
LOC102729790Regulator of nonsense transcripts 1-like. (678 aa)
LOC102726351poly(A) polymerase gamma-like. (164 aa)
NUDT21Cleavage and polyadenylation specificity factor subunit 5. (161 aa)
DDX19BATP-dependent RNA helicase DDX19B isoform X1. (518 aa)
LOC102741335ATP-dependent RNA helicase DDX19A-like. (113 aa)
CPSF4Cleavage and polyadenylation specificity factor subunit 4 isoform X1. (269 aa)
FNBP4Formin-binding protein 4 isoform X1. (1021 aa)
UPF1Regulator of nonsense transcripts 1-like. (373 aa)
PPP2R3BSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta. (596 aa)
PCF11pre-mRNA cleavage complex 2 protein Pcf11. (1555 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
LOC102736431Eukaryotic initiation factor 4A-III-like. (94 aa)
MAGOHProtein mago nashi homolog. (146 aa)
LOC102742356UPF0587 protein C1orf123 homolog. (160 aa)
LOC102729615RNA polymerase II subunit A C-terminal domain phosphatase SSU72-like isoform X2. (194 aa)
SMG6Telomerase-binding protein EST1A. (711 aa)
LOC102730629Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa)
LOC102741653Serine/threonine-protein phosphatase 4 regulatory subunit 1-like. (220 aa)
LOC102726384Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (390 aa)
PAPOLBPoly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (641 aa)
LOC102739075Hsc70-interacting protein-like isoform X1. (369 aa)
RBM8ARNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (174 aa)
SRRM1Serine/arginine repetitive matrix protein 1-like. (347 aa)
LOC102744119Cleavage stimulation factor subunit 3-like. (187 aa)
LOC102751025Protein mago nashi homolog. (93 aa)
MKRN1LOW QUALITY PROTEIN: makorin ring finger protein 1. (481 aa)
COPS5LOW QUALITY PROTEIN: COP9 signalosome subunit 5. (334 aa)
PABPC4Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (635 aa)
CPSF4LLOW QUALITY PROTEIN: cleavage and polyadenylation specific factor 4-like. (123 aa)
LOC102736167Serine/arginine repetitive matrix protein 1-like. (479 aa)
NXT2NTF2-related export protein 2 isoform X1. (142 aa)
ZC3H8Zinc finger CCCH domain-containing protein 8. (305 aa)
CPSF3Cleavage and polyadenylation specificity factor subunit 3. (684 aa)
NXF2BNuclear RNA export factor 2-like. (560 aa)
HBS1LHBS1-like protein. (162 aa)
LOC102748768Uncharacterized protein LOC102748768. (634 aa)
RBM3Glycine-rich RNA-binding protein 4, mitochondrial isoform X2. (156 aa)
DDX39BSpliceosome RNA helicase DDX39B isoform X1. (435 aa)
SERAC1Protein SERAC1. (513 aa)
RNPS1RNA-binding protein with serine-rich domain 1 isoform X1. (140 aa)
LOC102725708Zinc finger CCCH domain-containing protein 4-like. (754 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa)
CSTF3Cleavage stimulation factor subunit 3. (717 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
MKRN2Probable E3 ubiquitin-protein ligase makorin-2 isoform X1. (416 aa)
CSTF1Cleavage stimulation factor subunit 1 isoform X1. (431 aa)
CIRBPCold-inducible RNA-binding protein isoform X2. (172 aa)
CPSF2Cleavage and polyadenylation specificity factor subunit 2. (782 aa)
WDR33pre-mRNA 3' end processing protein WDR33-like. (1336 aa)
UPF3BRegulator of nonsense transcripts 3B isoform X1. (485 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PPP4R1Serine/threonine-protein phosphatase 4 regulatory subunit 1-like isoform X1. (367 aa)
PARP11Poly [ADP-ribose] polymerase. (338 aa)
NCBP2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (156 aa)
NXT1NTF2-related export protein 1. (140 aa)
DCLRE1ADNA cross-link repair 1A protein. (953 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform. (231 aa)
CPSF6Cleavage and polyadenylation specificity factor subunit 6. (552 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
CSTF2Cleavage stimulation factor subunit 2 isoform X1. (602 aa)
PIH1D3Protein PIH1D3. (214 aa)
RNMTmRNA cap guanine-N7 methyltransferase. (478 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
LOC102738520Zinc finger CCCH domain-containing protein 3-like. (554 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.