(46 nodes) Proteasome network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PSMA6	Proteasome subunit alpha type. (246 aa)
	LOC102742178	Proteasome subunit alpha type. (234 aa)
	PSMB2	Proteasome subunit beta. (201 aa)
	LOC102734657	26S proteasome non-ATPase regulatory subunit 1-like. (279 aa)
	GTSF1L	Gametocyte-specific factor 1-like isoform X1. (154 aa)
	PSMC6	26S protease regulatory subunit 10B. (291 aa)
	PSMD14	26S proteasome non-ATPase regulatory subunit 14. (310 aa)
	SHFM1	26S proteasome complex subunit DSS1. (70 aa)
	MORF4L2	Mortality factor 4-like protein 2 isoform X1. (288 aa)
	PSMC5	26S protease regulatory subunit 8; Belongs to the AAA ATPase family. (406 aa)
	PSMB8	Proteasome subunit beta. (276 aa)
	LOC102733981	26S proteasome non-ATPase regulatory subunit 2-like. (125 aa)
	PSME1	Proteasome activator complex subunit 1 isoform X1. (249 aa)
	PSME2	Proteasome activator complex subunit 2 isoform X1. (239 aa)
	PSME3	Proteasome activator complex subunit 3 isoform X3. (254 aa)
	PSMD8	LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 8. (351 aa)
	PSMD4	26S proteasome non-ATPase regulatory subunit 4. (377 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	PSMD7	26S proteasome non-ATPase regulatory subunit 7-like. (324 aa)
	PSMB6	Proteasome subunit beta. (239 aa)
	PSMA3	Proteasome subunit alpha type. (255 aa)
	PSMA7	Proteasome subunit alpha type. (248 aa)
	LOC102730851	26S protease regulatory subunit 6A-like. (200 aa)
	LOC102735156	Proteasome subunit beta type-5-like. (119 aa)
	LOC102732367	Proteasome subunit beta type-1-like. (140 aa)
	LOC102729219	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (778 aa)
	PSMD6	26S proteasome non-ATPase regulatory subunit 6 isoform X1. (389 aa)
	LOC102726381	26S proteasome non-ATPase regulatory subunit 1-like. (574 aa)
	PSMA5	Proteasome subunit alpha type. (235 aa)
	PSMA4	Proteasome subunit alpha type. (261 aa)
	LOC102735127	26S protease regulatory subunit 4-like isoform X1; Belongs to the AAA ATPase family. (440 aa)
	PSMD9	26S proteasome non-ATPase regulatory subunit 9 isoform X1. (223 aa)
	PSMB11	Proteasome subunit beta. (285 aa)
	PSMB5	Proteasome subunit beta type-5. (160 aa)
	MORF4L1	Mortality factor 4-like protein 1 isoform X1. (235 aa)
	PSMF1	Proteasome inhibitor PI31 subunit. (128 aa)
	PSMA8	Proteasome subunit alpha type. (250 aa)
	MSL3	Male-specific lethal 3 homolog isoform X1. (522 aa)
	ADRM1	Proteasomal ubiquitin receptor ADRM1 isoform X1. (406 aa)
	OSBPL2	Oxysterol-binding protein; Belongs to the OSBP family. (480 aa)
	LOC102747943	UPF0536 protein C12orf66 homolog. (445 aa)
	PSMB4	Proteasome subunit beta; Belongs to the peptidase T1B family. (264 aa)
	PSMD11	26S proteasome non-ATPase regulatory subunit 11. (422 aa)
	GTSF1	Gametocyte-specific factor 1. (167 aa)
	PSMB10	Proteasome subunit beta. (273 aa)
	PSMC2	26S protease regulatory subunit 7; Belongs to the AAA ATPase family. (433 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRM1	LOC102726381	A0A2U3YLT7	A0A2U3Z331	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S proteasome non-ATPase regulatory subunit 1-like.	0.967
ADRM1	LOC102729219	A0A2U3YLT7	A0A2U3Z6Q4	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family.	0.965
ADRM1	LOC102730851	A0A2U3YLT7	A0A2U3Z8X8	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S protease regulatory subunit 6A-like.	0.993
ADRM1	LOC102732367	A0A2U3YLT7	A0A2U3Z731	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome subunit beta type-1-like.	0.967
ADRM1	LOC102733981	A0A2U3YLT7	A0A2U3Y3C6	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S proteasome non-ATPase regulatory subunit 2-like.	0.965
ADRM1	LOC102734657	A0A2U3YLT7	A0A2U3XS75	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S proteasome non-ATPase regulatory subunit 1-like.	0.967
ADRM1	LOC102735127	A0A2U3YLT7	A0A2U3YX40	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S protease regulatory subunit 4-like isoform X1; Belongs to the AAA ATPase family.	0.998
ADRM1	LOC102735156	A0A2U3YLT7	A0A2U3Z7I8	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome subunit beta type-5-like.	0.849
ADRM1	LOC102742178	A0A2U3YLT7	A0A2U3XMG0	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome subunit alpha type.	0.968
ADRM1	OSBPL2	A0A2U3YLT7	A0A2U3YLT1	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Oxysterol-binding protein; Belongs to the OSBP family.	0.889
ADRM1	PSMA3	A0A2U3YLT7	A0A2U3YKE9	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome subunit alpha type.	0.951
ADRM1	PSMA4	A0A2U3YLT7	A0A2U3YXE5	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome subunit alpha type.	0.968
ADRM1	PSMA5	A0A2U3YLT7	A0A2U3Z213	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome subunit alpha type.	0.957
ADRM1	PSMA6	A0A2U3YLT7	A0A2U3XLE4	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome subunit alpha type.	0.952
ADRM1	PSMA7	A0A2U3YLT7	A0A2U3YLS9	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome subunit alpha type.	0.909
ADRM1	PSMA8	A0A2U3YLT7	A0A2U3YPI2	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome subunit alpha type.	0.909
ADRM1	PSMB10	A0A2U3YLT7	A0A2U3XF99	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome subunit beta.	0.952
ADRM1	PSMB11	A0A2U3YLT7	A0A2U3YS58	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome subunit beta.	0.849
ADRM1	PSMB2	A0A2U3YLT7	A0A2U3XMR0	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome subunit beta.	0.969
ADRM1	PSMB4	A0A2U3YLT7	A0A2U3XAT0	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome subunit beta; Belongs to the peptidase T1B family.	0.964