STRINGSTRING
LOC102736922 LOC102736922 LOC102740880 LOC102740880 LOC102745028 LOC102745028 LOC102731038 LOC102731038 LOC102733954 LOC102733954 LOC102727998 LOC102727998 LOC102732556 LOC102732556 PRKACA PRKACA TNNC2 TNNC2 LOC102729925 LOC102729925 PHKG2 PHKG2 LOC102749347 LOC102749347 ARSI ARSI CAMK2A CAMK2A LOC102746549 LOC102746549 MYLK3 MYLK3 AVPR1A AVPR1A ADORA2A ADORA2A PLCL2 PLCL2 CAMK4 CAMK4 PLCD1 PLCD1 LOC102734642 LOC102734642 LOC102730623 LOC102730623 HTR4 HTR4 VDAC2 VDAC2 LOC102730715 LOC102730715 LOC102751087 LOC102751087 ORAI1 ORAI1 GNAL GNAL LOC102748816 LOC102748816 CATSPER4 CATSPER4 PDGFRA PDGFRA OTOP1 OTOP1 DRD5 DRD5 LOC102737030 LOC102737030 PDGFB PDGFB ATP2A3 ATP2A3 STIM1 STIM1 LOC102729478 LOC102729478 PLCB3 PLCB3 LOC102732520 LOC102732520 ADRA1B ADRA1B P2RX2 P2RX2 LOC102746012 LOC102746012 GRIN2D GRIN2D SPHK2 SPHK2 CHRM2 CHRM2 LOC102733606 LOC102733606 CALM3 CALM3 ATP2C1 ATP2C1 GNA15 GNA15 GNA11 GNA11 ADCY9 ADCY9 P2RX6 P2RX6 LOC102735415 LOC102735415 ADRA1D ADRA1D VDAC3 VDAC3 ITPR3 ITPR3 CASQ1 CASQ1 HRH2 HRH2 PTGFR PTGFR LOC102738071 LOC102738071 TNNC1 TNNC1 LOC102751010 LOC102751010 GNA14 GNA14 CHRM5 CHRM5 LRRN4CL LRRN4CL BSCL2 BSCL2 CHRM1 CHRM1 PLCZ1 PLCZ1 PSKH1 PSKH1 PPP3R1 PPP3R1 PHKG1 PHKG1 ORAI3 ORAI3 STIM2 STIM2 LOC102742552 LOC102742552 HTR5A HTR5A TACR2 TACR2 ERBB3 ERBB3 PDE1B PDE1B STK33 STK33 P2RX3 P2RX3 HTR2C HTR2C SLC8A1 SLC8A1 ZRANB2 ZRANB2 PPP3R2 PPP3R2 CCDC109B CCDC109B PDGFC PDGFC LOC102730944 LOC102730944 CYSLTR1 CYSLTR1 PTGER1 PTGER1 CACNA1F CACNA1F TBXA2R TBXA2R LTB4R2 LTB4R2 CAMK1 CAMK1 LOC102746494 LOC102746494 ATP2C2 ATP2C2 GPR150 GPR150 CCKAR CCKAR PTAFR PTAFR PNCK PNCK PHKA2 PHKA2 CYSLTR2 CYSLTR2 CHRNA7 CHRNA7 CACNA1G CACNA1G MCOLN3 MCOLN3 LOC102740305 LOC102740305 PTRHD1 PTRHD1 PLN PLN SLC25A5 SLC25A5 AVPR1B AVPR1B ITPR1 ITPR1 LOC102747594 LOC102747594 LOC102742813 LOC102742813 HTR2A HTR2A ITPR2 ITPR2 HTR7 HTR7 GRIN1 GRIN1 CAMKV CAMKV P2RX4 P2RX4 P2RX7 P2RX7 PRKACB PRKACB ADRA1A ADRA1A ITPKA ITPKA OXTR OXTR GRM1 GRM1 GRPR GRPR PLCD3 PLCD3 BDKRB2 BDKRB2 RCSD1 RCSD1 PLCE1 PLCE1 F2R F2R LOC102735676 LOC102735676 SLC25A4 SLC25A4 PPIF PPIF GRIN2A GRIN2A SLC8A3 SLC8A3 LOC102751218 LOC102751218 HTR2B HTR2B HRH1 HRH1 ORAI2 ORAI2 CAMK1G CAMK1G CAMK2G CAMK2G TACR3 TACR3 CCKBR CCKBR HTR6 HTR6 DRD1 DRD1 EFCAB13 EFCAB13 LHCGR LHCGR LOC102735756 LOC102735756 CALML4 CALML4 LOC102750030 LOC102750030 ITPKC ITPKC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LOC102736922Calmodulin-like; Belongs to the calmodulin family. (223 aa)
LOC102740880Nitric oxide synthase, endothelial-like. (619 aa)
LOC102745028Endothelin-1 receptor-like. (178 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
LOC102733954Calmodulin-like protein 4-like. (119 aa)
LOC102727998P2X purinoceptor 3-like. (281 aa)
LOC102732556Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (590 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
TNNC2Troponin C, skeletal muscle. (160 aa)
LOC102729925B1 bradykinin receptor-like. (343 aa)
PHKG2Phosphorylase b kinase gamma catalytic chain, liver/testis isoform. (352 aa)
LOC1027493475-hydroxytryptamine receptor 5B-like. (370 aa)
ARSIArylsulfatase I. (575 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha. (476 aa)
LOC102746549Glutamate receptor ionotropic, NMDA 2C-like. (348 aa)
MYLK3Myosin light chain kinase 3. (99 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. (381 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
PLCL2Phosphoinositide phospholipase C. (909 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV. (360 aa)
PLCD1Phosphoinositide phospholipase C. (597 aa)
LOC102734642Guanine nucleotide-binding protein G(Olf) subunit alpha-like. (209 aa)
LOC102730623Beta-2 adrenergic receptor-like. (418 aa)
HTR45-hydroxytryptamine receptor 4-like; Belongs to the G-protein coupled receptor 1 family. (388 aa)
VDAC2Voltage-dependent anion-selective channel protein 2 isoform X1. (294 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
LOC102751087Nitric oxide synthase, inducible-like. (430 aa)
ORAI1Calcium release-activated calcium channel protein 1. (302 aa)
GNALGuanine nucleotide-binding protein G(Olf) subunit alpha. (174 aa)
LOC1027488165-hydroxytryptamine receptor 2A-like; Belongs to the G-protein coupled receptor 1 family. (204 aa)
CATSPER4Cation channel sperm-associated protein 4. (337 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
OTOP1Otopetrin-1. (418 aa)
DRD5D(1B) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (432 aa)
LOC102737030Receptor tyrosine-protein kinase erbB-2-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. (627 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
ATP2A3Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (604 aa)
STIM1Stromal interaction molecule 1. (215 aa)
LOC102729478Endothelin-1 receptor-like; Belongs to the G-protein coupled receptor 1 family. (253 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
LOC102732520Calcium-transporting ATPase type 2C member 1-like; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (395 aa)
ADRA1Balpha-1B adrenergic receptor. (345 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (471 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
GRIN2DGlutamate receptor ionotropic, NMDA 2D. (840 aa)
SPHK2Sphingosine kinase 2 isoform X1. (656 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
LOC1027336061-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like. (156 aa)
CALM3Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
ATP2C1Calcium-transporting ATPase type 2C member 1-like isoform X1; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (563 aa)
GNA15Guanine nucleotide-binding protein subunit alpha-15. (374 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
P2RX6P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (393 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
ADRA1Dalpha-1D adrenergic receptor. (509 aa)
VDAC3Voltage-dependent anion-selective channel protein 3 isoform X1. (284 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
CASQ1Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (393 aa)
HRH2Histamine H2 receptor; Belongs to the G-protein coupled receptor 1 family. (359 aa)
PTGFRProstaglandin F2-alpha receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
LOC102738071Calmodulin-like; Belongs to the calmodulin family. (113 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (161 aa)
LOC102751010Nitric oxide synthase, inducible-like. (531 aa)
GNA14Guanine nucleotide-binding protein subunit alpha-14. (355 aa)
CHRM5Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (532 aa)
LRRN4CLLRRN4 C-terminal-like protein. (237 aa)
BSCL2Seipin isoform X2. (394 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
PLCZ1Phosphoinositide phospholipase C. (484 aa)
PSKH1Serine/threonine-protein kinase H1; Belongs to the protein kinase superfamily. (424 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
PHKG1Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1; Belongs to the protein kinase superfamily. (387 aa)
ORAI3Protein orai-3. (296 aa)
STIM2Stromal interaction molecule 2-like. (794 aa)
LOC102742552Platelet-derived growth factor D-like isoform X1. (370 aa)
HTR5A5-hydroxytryptamine receptor 5A. (358 aa)
TACR2substance-K receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1339 aa)
PDE1BPhosphodiesterase. (535 aa)
STK33Serine/threonine-protein kinase 33. (521 aa)
P2RX3P2X purinoceptor 3. (147 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
SLC8A1Sodium/calcium exchanger 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (970 aa)
ZRANB2Zinc finger Ran-binding domain-containing protein 2; May interfere with constitutive 5'-splice site selection. Belongs to the ZRANB2 family. (330 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
CCDC109BMitochondrial calcium uniporter regulatory subunit MCUb. (84 aa)
PDGFCPlatelet-derived growth factor C-like; Belongs to the PDGF/VEGF growth factor family. (345 aa)
LOC102730944Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (90 aa)
CYSLTR1Cysteinyl leukotriene receptor 1. (340 aa)
PTGER1Prostaglandin E2 receptor EP1 subtype. (149 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
TBXA2RThromboxane A2 receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (343 aa)
LTB4R2Leukotriene B4 receptor 2. (358 aa)
CAMK1Calcium/calmodulin-dependent protein kinase type 1 isoform X1; Belongs to the protein kinase superfamily. (409 aa)
LOC102746494Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (226 aa)
ATP2C2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (946 aa)
GPR150Probable G-protein coupled receptor 150. (399 aa)
CCKARCholecystokinin receptor type A; Belongs to the G-protein coupled receptor 1 family. (428 aa)
PTAFRPlatelet-activating factor receptor; Belongs to the G-protein coupled receptor 1 family. (344 aa)
PNCKCalcium/calmodulin-dependent protein kinase type 1B isoform X1; Belongs to the protein kinase superfamily. (343 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (617 aa)
CYSLTR2Cysteinyl leukotriene receptor 2. (345 aa)
CHRNA7Neuronal acetylcholine receptor subunit alpha-7-like isoform X2. (499 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2266 aa)
MCOLN3Mucolipin-3 isoform X1. (553 aa)
LOC1027403051-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like. (211 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
SLC25A5ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
LOC102747594c-X-C chemokine receptor type 4-like; Belongs to the G-protein coupled receptor 1 family. (353 aa)
LOC102742813Neuroendocrine secretory protein 55-like. (246 aa)
HTR2A5-hydroxytryptamine receptor 2A. (263 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
HTR75-hydroxytryptamine receptor 7. (435 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1 isoform X1. (943 aa)
CAMKVcaM kinase-like vesicle-associated protein isoform X1. (507 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (591 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
ADRA1Aalpha-1A adrenergic receptor. (465 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (528 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
GRM1Metabotropic glutamate receptor 1. (887 aa)
GRPRGastrin-releasing peptide receptor. (290 aa)
PLCD3Phosphoinositide phospholipase C. (778 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
RCSD1capZ-interacting protein. (366 aa)
PLCE1Phosphoinositide phospholipase C. (2299 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
LOC102735676substance-P receptor-like. (212 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (210 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A. (1308 aa)
SLC8A3Sodium/calcium exchanger 3 isoform X3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
LOC102751218Voltage-dependent anion-selective channel protein 1-like. (280 aa)
HTR2B5-hydroxytryptamine receptor 2B. (526 aa)
HRH1Histamine H1 receptor; Belongs to the G-protein coupled receptor 1 family. (487 aa)
ORAI2Protein orai-2 isoform X1. (254 aa)
CAMK1GCalcium/calmodulin-dependent protein kinase type 1G. (220 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (574 aa)
TACR3neuromedin-K receptor; Belongs to the G-protein coupled receptor 1 family. (461 aa)
CCKBRGastrin/cholecystokinin type B receptor; Belongs to the G-protein coupled receptor 1 family. (455 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (440 aa)
DRD1D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (446 aa)
EFCAB13LOW QUALITY PROTEIN: EF-hand calcium binding domain 13. (905 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (483 aa)
LOC102735756alpha-1B adrenergic receptor-like. (213 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like 4. (199 aa)
LOC102750030Protein-tyrosine kinase 2-beta-like. (125 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (493 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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