STRINGSTRING
LOC102736922 LOC102736922 GUCY1B3 GUCY1B3 GUCY1A3 GUCY1A3 PPP3R2 PPP3R2 SLC8A1 SLC8A1 RGS2 RGS2 MRVI1 MRVI1 GATA4 GATA4 ADCY6 ADCY6 MAP2K1 MAP2K1 ATF4 ATF4 PPP3R1 PPP3R1 GNA12 GNA12 NFATC3 NFATC3 PDE2A PDE2A ADRA2B ADRA2B LOC102740567 LOC102740567 ATP1A3 ATP1A3 LOC102738071 LOC102738071 KCNMB4 KCNMB4 LOC102738979 LOC102738979 LOC102726697 LOC102726697 LOC102734862 LOC102734862 AADAC AADAC AADACL2 AADACL2 CREB1 CREB1 NPPC NPPC LOC102751218 LOC102751218 SLC8A3 SLC8A3 PPIF PPIF SLC25A4 SLC25A4 KCNMB1 KCNMB1 NPPA NPPA NPPB NPPB IRS1 IRS1 ADRA2A ADRA2A BDKRB2 BDKRB2 LOC102731168 LOC102731168 SRF SRF PTK7 PTK7 ADRA1A ADRA1A PPP1CC PPP1CC GNAI2 GNAI2 PRKG2 PRKG2 ATP1B3 ATP1B3 ITPR2 ITPR2 AKT1 AKT1 CACNA1F CACNA1F ATF6B ATF6B VASP VASP CREB3L3 CREB3L3 MAP2K2 MAP2K2 ATP1B2 ATP1B2 ATP1B1 ATP1B1 ROCK2 ROCK2 AKT3 AKT3 RAF1 RAF1 CNGA1 CNGA1 PDE5A PDE5A PRKG1 PRKG1 PTRHD1 PTRHD1 PLN PLN SLC25A5 SLC25A5 PPP1CB PPP1CB ITPR1 ITPR1 ATF2 ATF2 KNG1 KNG1 PDE3B PDE3B ATP1A2 ATP1A2 ATP1A4 ATP1A4 MAPK1 MAPK1 ITPR3 ITPR3 NPR2 NPR2 VDAC3 VDAC3 GTF2I GTF2I ADRA1D ADRA1D FXYD2 FXYD2 MEF2B MEF2B ADCY9 ADCY9 MYH3 MYH3 GNA11 GNA11 MEF2C MEF2C LOC102738224 LOC102738224 CALM3 CALM3 LOC102746012 LOC102746012 MEF2A MEF2A ADRA1B ADRA1B KCNMB2 KCNMB2 KCNMB3 KCNMB3 NFATC1 NFATC1 LOC102725943 LOC102725943 ATP1B4 ATP1B4 PLCB3 PLCB3 LOC102729478 LOC102729478 ATP2A3 ATP2A3 CREB3L1 CREB3L1 NPR1 NPR1 ATP1A1 ATP1A1 LOC102735730 LOC102735730 PPP1CA PPP1CA TRPC6 TRPC6 LOC102730715 LOC102730715 VDAC2 VDAC2 LOC102730623 LOC102730623 LOC102740654 LOC102740654 INS INS MYLK3 MYLK3 OPRD1 OPRD1 LOC102742564 LOC102742564 LOC102733954 LOC102733954 LOC102731038 LOC102731038 LOC102745028 LOC102745028 LOC102740880 LOC102740880 LOC102730020 LOC102730020 LOC102749357 LOC102749357 LOC102749446 LOC102749446 LOC102726696 LOC102726696 LOC102740174 LOC102740174 CALML4 CALML4 LOC102735756 LOC102735756
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LOC102736922Calmodulin-like; Belongs to the calmodulin family. (223 aa)
GUCY1B3Guanylate cyclase soluble subunit beta-1 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
GUCY1A3Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
SLC8A1Sodium/calcium exchanger 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (970 aa)
RGS2Regulator of G-protein signaling 2. (211 aa)
MRVI1Protein MRVI1. (597 aa)
GATA4Transcription factor GATA-4 isoform X1. (443 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12 isoform X1. (305 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1075 aa)
PDE2APhosphodiesterase. (943 aa)
ADRA2Balpha-2B adrenergic receptor. (444 aa)
LOC102740567Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (114 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
LOC102738071Calmodulin-like; Belongs to the calmodulin family. (113 aa)
KCNMB4Calcium-activated potassium channel subunit beta-4. (210 aa)
LOC102738979Adenosine receptor A3-like. (173 aa)
LOC102726697Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
AADACArylacetamide deacetylase. (399 aa)
AADACL2LOW QUALITY PROTEIN: arylacetamide deacetylase-like 2. (400 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
NPPCC-type natriuretic peptide isoform X1. (126 aa)
LOC102751218Voltage-dependent anion-selective channel protein 1-like. (280 aa)
SLC8A3Sodium/calcium exchanger 3 isoform X3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (210 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
KCNMB1Calcium-activated potassium channel subunit beta-1. (191 aa)
NPPANatriuretic peptides A. (150 aa)
NPPBNatriuretic peptides B. (132 aa)
IRS1Insulin receptor substrate 1-like isoform X1. (1236 aa)
ADRA2Aalpha-2A adrenergic receptor. (350 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
LOC102731168LOW QUALITY PROTEIN: potassium channel subfamily U member 1-like. (1171 aa)
SRFSerum response factor. (508 aa)
PTK7Inactive tyrosine-protein kinase 7 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
ADRA1Aalpha-1A adrenergic receptor. (465 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
PRKG2cGMP-dependent protein kinase 2. (553 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (623 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (382 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (466 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ROCK2Rho-associated protein kinase 2. (850 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
CNGA1cGMP-gated cation channel alpha-1. (694 aa)
PDE5APhosphodiesterase. (865 aa)
PRKG1cGMP-dependent protein kinase 1. (193 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
SLC25A5ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X2. (505 aa)
KNG1Kininogen-1 isoform X1. (652 aa)
PDE3BPhosphodiesterase. (1180 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
NPR2Guanylate cyclase. (1047 aa)
VDAC3Voltage-dependent anion-selective channel protein 3 isoform X1. (284 aa)
GTF2IGeneral transcription factor II-I. (992 aa)
ADRA1Dalpha-1D adrenergic receptor. (509 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (66 aa)
MEF2BMyocyte-specific enhancer factor 2B. (368 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
MYH3Myosin-3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
MEF2CMyocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
LOC102738224LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like. (612 aa)
CALM3Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X1. (487 aa)
ADRA1Balpha-1B adrenergic receptor. (345 aa)
KCNMB2Calcium-activated potassium channel subunit beta-2. (235 aa)
KCNMB3LOW QUALITY PROTEIN: calcium-activated potassium channel subunit beta-3. (281 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
LOC102725943Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (360 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
LOC102729478Endothelin-1 receptor-like; Belongs to the G-protein coupled receptor 1 family. (253 aa)
ATP2A3Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (604 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
NPR1Atrial natriuretic peptide receptor 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (242 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (673 aa)
LOC102735730Sodium/potassium-transporting ATPase subunit alpha-1-like; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (346 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
TRPC6Short transient receptor potential channel 6-like isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (932 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
VDAC2Voltage-dependent anion-selective channel protein 2 isoform X1. (294 aa)
LOC102730623Beta-2 adrenergic receptor-like. (418 aa)
LOC102740654Phosphoinositide 3-kinase regulatory subunit 5-like. (111 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
MYLK3Myosin light chain kinase 3. (99 aa)
OPRD1Delta-type opioid receptor-like; Belongs to the G-protein coupled receptor 1 family. (288 aa)
LOC102742564Rho-associated protein kinase 2-like. (530 aa)
LOC102733954Calmodulin-like protein 4-like. (119 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
LOC102745028Endothelin-1 receptor-like. (178 aa)
LOC102740880Nitric oxide synthase, endothelial-like. (619 aa)
LOC102730020Myosin-7-like. (703 aa)
LOC102749357Myosin-4-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (342 aa)
LOC102749446Myosin-1-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (190 aa)
LOC102726696Myosin-2-like. (199 aa)
LOC102740174Myosin-2-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (236 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like 4. (199 aa)
LOC102735756alpha-1B adrenergic receptor-like. (213 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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