STRINGSTRING
KCNMB3 KCNMB3 LOC102735756 LOC102735756 CALML4 CALML4 LOC102740174 LOC102740174 LOC102726696 LOC102726696 LOC102749446 LOC102749446 LOC102749357 LOC102749357 LOC102730020 LOC102730020 LOC102740880 LOC102740880 LOC102745028 LOC102745028 LOC102731038 LOC102731038 LOC102733954 LOC102733954 LOC102742564 LOC102742564 OPRD1 OPRD1 MYLK3 MYLK3 INS INS LOC102740654 LOC102740654 LOC102730623 LOC102730623 VDAC2 VDAC2 LOC102730715 LOC102730715 TRPC6 TRPC6 PPP1CA PPP1CA LOC102735730 LOC102735730 ATP1A1 ATP1A1 NPR1 NPR1 CREB3L1 CREB3L1 ATP2A3 ATP2A3 LOC102729478 LOC102729478 PLCB3 PLCB3 ATP1B4 ATP1B4 LOC102725943 LOC102725943 NFATC1 NFATC1 KCNMB2 KCNMB2 ADRA1B ADRA1B MEF2A MEF2A LOC102746012 LOC102746012 CALM3 CALM3 LOC102738224 LOC102738224 MEF2C MEF2C GNA11 GNA11 MYH3 MYH3 ADCY9 ADCY9 MEF2B MEF2B FXYD2 FXYD2 ADRA1D ADRA1D GTF2I GTF2I VDAC3 VDAC3 NPR2 NPR2 ITPR3 ITPR3 MAPK1 MAPK1 ATP1A4 ATP1A4 ATP1A2 ATP1A2 PDE3B PDE3B KNG1 KNG1 ATF2 ATF2 ITPR1 ITPR1 PPP1CB PPP1CB SLC25A5 SLC25A5 PLN PLN PTRHD1 PTRHD1 PRKG1 PRKG1 PDE5A PDE5A CNGA1 CNGA1 RAF1 RAF1 AKT3 AKT3 ROCK2 ROCK2 ATP1B1 ATP1B1 ATP1B2 ATP1B2 MAP2K2 MAP2K2 CREB3L3 CREB3L3 VASP VASP ATF6B ATF6B CACNA1F CACNA1F AKT1 AKT1 ITPR2 ITPR2 ATP1B3 ATP1B3 PRKG2 PRKG2 GNAI2 GNAI2 PPP1CC PPP1CC ADRA1A ADRA1A PTK7 PTK7 SRF SRF LOC102731168 LOC102731168 BDKRB2 BDKRB2 ADRA2A ADRA2A IRS1 IRS1 NPPB NPPB NPPA NPPA KCNMB1 KCNMB1 SLC25A4 SLC25A4 PPIF PPIF SLC8A3 SLC8A3 LOC102751218 LOC102751218 NPPC NPPC CREB1 CREB1 AADACL2 AADACL2 AADAC AADAC LOC102734862 LOC102734862 LOC102726697 LOC102726697 LOC102738979 LOC102738979 KCNMB4 KCNMB4 LOC102738071 LOC102738071 ATP1A3 ATP1A3 LOC102740567 LOC102740567 ADRA2B ADRA2B PDE2A PDE2A NFATC3 NFATC3 GNA12 GNA12 PPP3R1 PPP3R1 ATF4 ATF4 MAP2K1 MAP2K1 ADCY6 ADCY6 GATA4 GATA4 MRVI1 MRVI1 RGS2 RGS2 SLC8A1 SLC8A1 PPP3R2 PPP3R2 GUCY1A3 GUCY1A3 GUCY1B3 GUCY1B3 LOC102736922 LOC102736922
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNMB3LOW QUALITY PROTEIN: calcium-activated potassium channel subunit beta-3. (281 aa)
LOC102735756alpha-1B adrenergic receptor-like. (213 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like 4. (199 aa)
LOC102740174Myosin-2-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (236 aa)
LOC102726696Myosin-2-like. (199 aa)
LOC102749446Myosin-1-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (190 aa)
LOC102749357Myosin-4-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (342 aa)
LOC102730020Myosin-7-like. (703 aa)
LOC102740880Nitric oxide synthase, endothelial-like. (619 aa)
LOC102745028Endothelin-1 receptor-like. (178 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
LOC102733954Calmodulin-like protein 4-like. (119 aa)
LOC102742564Rho-associated protein kinase 2-like. (530 aa)
OPRD1Delta-type opioid receptor-like; Belongs to the G-protein coupled receptor 1 family. (288 aa)
MYLK3Myosin light chain kinase 3. (99 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LOC102740654Phosphoinositide 3-kinase regulatory subunit 5-like. (111 aa)
LOC102730623Beta-2 adrenergic receptor-like. (418 aa)
VDAC2Voltage-dependent anion-selective channel protein 2 isoform X1. (294 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
TRPC6Short transient receptor potential channel 6-like isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (932 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
LOC102735730Sodium/potassium-transporting ATPase subunit alpha-1-like; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (346 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (673 aa)
NPR1Atrial natriuretic peptide receptor 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (242 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
ATP2A3Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (604 aa)
LOC102729478Endothelin-1 receptor-like; Belongs to the G-protein coupled receptor 1 family. (253 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (360 aa)
LOC102725943Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
KCNMB2Calcium-activated potassium channel subunit beta-2. (235 aa)
ADRA1Balpha-1B adrenergic receptor. (345 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X1. (487 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
CALM3Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
LOC102738224LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like. (612 aa)
MEF2CMyocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
MYH3Myosin-3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
MEF2BMyocyte-specific enhancer factor 2B. (368 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (66 aa)
ADRA1Dalpha-1D adrenergic receptor. (509 aa)
GTF2IGeneral transcription factor II-I. (992 aa)
VDAC3Voltage-dependent anion-selective channel protein 3 isoform X1. (284 aa)
NPR2Guanylate cyclase. (1047 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
PDE3BPhosphodiesterase. (1180 aa)
KNG1Kininogen-1 isoform X1. (652 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X2. (505 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
SLC25A5ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
PRKG1cGMP-dependent protein kinase 1. (193 aa)
PDE5APhosphodiesterase. (865 aa)
CNGA1cGMP-gated cation channel alpha-1. (694 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
ROCK2Rho-associated protein kinase 2. (850 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (466 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (382 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (623 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
PRKG2cGMP-dependent protein kinase 2. (553 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
ADRA1Aalpha-1A adrenergic receptor. (465 aa)
PTK7Inactive tyrosine-protein kinase 7 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
SRFSerum response factor. (508 aa)
LOC102731168LOW QUALITY PROTEIN: potassium channel subfamily U member 1-like. (1171 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
ADRA2Aalpha-2A adrenergic receptor. (350 aa)
IRS1Insulin receptor substrate 1-like isoform X1. (1236 aa)
NPPBNatriuretic peptides B. (132 aa)
NPPANatriuretic peptides A. (150 aa)
KCNMB1Calcium-activated potassium channel subunit beta-1. (191 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
PPIFPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (210 aa)
SLC8A3Sodium/calcium exchanger 3 isoform X3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
LOC102751218Voltage-dependent anion-selective channel protein 1-like. (280 aa)
NPPCC-type natriuretic peptide isoform X1. (126 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
AADACL2LOW QUALITY PROTEIN: arylacetamide deacetylase-like 2. (400 aa)
AADACArylacetamide deacetylase. (399 aa)
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
LOC102726697Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
LOC102738979Adenosine receptor A3-like. (173 aa)
KCNMB4Calcium-activated potassium channel subunit beta-4. (210 aa)
LOC102738071Calmodulin-like; Belongs to the calmodulin family. (113 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
LOC102740567Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (114 aa)
ADRA2Balpha-2B adrenergic receptor. (444 aa)
PDE2APhosphodiesterase. (943 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1075 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12 isoform X1. (305 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
GATA4Transcription factor GATA-4 isoform X1. (443 aa)
MRVI1Protein MRVI1. (597 aa)
RGS2Regulator of G-protein signaling 2. (211 aa)
SLC8A1Sodium/calcium exchanger 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (970 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
GUCY1A3Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
GUCY1B3Guanylate cyclase soluble subunit beta-1 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
LOC102736922Calmodulin-like; Belongs to the calmodulin family. (223 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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