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LOC102745211 LOC102745211 TSHB TSHB PDE4D PDE4D LOC102726446 LOC102726446 ADCYAP1 ADCYAP1 GRIN3A GRIN3A CNGB3 CNGB3 HTR1F HTR1F LOC102736922 LOC102736922 LOC102746012 LOC102746012 LOC102739131 LOC102739131 GRIN2D GRIN2D CHRM2 CHRM2 LOC102727345 LOC102727345 CALM3 CALM3 MC2R MC2R ADCY9 ADCY9 RRAS RRAS FXYD2 FXYD2 GHSR GHSR GRIN2A GRIN2A LOC102744630 LOC102744630 F2R F2R NPPA NPPA PTGER2 PTGER2 PLCE1 PLCE1 VIP VIP PDE4B PDE4B OXTR OXTR VAV3 VAV3 PRKACB PRKACB PPP1CC PPP1CC GRIN1 GRIN1 GNAI2 GNAI2 ATP1B3 ATP1B3 HTR1D HTR1D MAPK8 MAPK8 PTCH1 PTCH1 AKT1 AKT1 CACNA1F CACNA1F QPCTL QPCTL GIPR GIPR CREB3L3 CREB3L3 MAP2K2 MAP2K2 ATP1B2 ATP1B2 GHRL GHRL JUN JUN PAK1 PAK1 SLC9A1 SLC9A1 ATP1B1 ATP1B1 GPR150 GPR150 ROCK2 ROCK2 AKT3 AKT3 RAP1B RAP1B LOC102736905 LOC102736905 GLI1 GLI1 RAF1 RAF1 CNGA1 CNGA1 PDE4A PDE4A PTRHD1 PTRHD1 PLN PLN SST SST PPP1CB PPP1CB RAPGEF4 RAPGEF4 HTR1A HTR1A EDN2 EDN2 PLD1 PLD1 RAC2 RAC2 TNNI3 TNNI3 LOC102742813 LOC102742813 FFAR2 FFAR2 PLD2 PLD2 PDE3B PDE3B ACOX3 ACOX3 ATP1A2 ATP1A2 ATP1A4 ATP1A4 MAPK1 MAPK1 TIAM1 TIAM1 HHIP HHIP LOC102733505 LOC102733505 PDE10A PDE10A MAPK10 MAPK10 NPY NPY ADCY6 ADCY6 CFTR CFTR CAMK2G CAMK2G CREB1 CREB1 TSHR TSHR LOC102734862 LOC102734862 POMC POMC LOC102726697 LOC102726697 GRIA2 GRIA2 HTR6 HTR6 NFKB1 NFKB1 DRD1 DRD1 PIK3R3 PIK3R3 LOC102738071 LOC102738071 NFKBIA NFKBIA ATP1A3 ATP1A3 LOC102740959 LOC102740959 LOC102738651 LOC102738651 CHRM1 CHRM1 EP300 EP300 SSTR1 SSTR1 LOC102747630 LOC102747630 MAP2K1 MAP2K1 LHCGR LHCGR HCAR1 HCAR1 HCAR3 HCAR3 CALML4 CALML4 LOC102751021 LOC102751021 LOC102739372 LOC102739372 LOC102745028 LOC102745028 LOC102731038 LOC102731038 LOC102748835 LOC102748835 LOC102748045 LOC102748045 LOC102745857 LOC102745857 LOC102726189 LOC102726189 LOC102733954 LOC102733954 LOC102732257 LOC102732257 PRKACA PRKACA LOC102735556 LOC102735556 CNGA2 CNGA2 LOC102742564 LOC102742564 ARSI ARSI CAMK2A CAMK2A LOC102746549 LOC102746549 ARAP3 ARAP3 PPP1R1B PPP1R1B ADORA2A ADORA2A LHB LHB CAMK4 CAMK4 PPARA PPARA LOC102730623 LOC102730623 HTR4 HTR4 PPP1CA PPP1CA ORAI1 ORAI1 LOC102735730 LOC102735730 ATP1A1 ATP1A1 FXYD1 FXYD1 SOX10 SOX10 NPR1 NPR1 CREB3L1 CREB3L1 GRIA1 GRIA1 CNGA4 CNGA4 HTR1E HTR1E DRD5 DRD5 LOC102736516 LOC102736516 GCG GCG CREBBP CREBBP NPY1R NPY1R ATP2A3 ATP2A3 LOC102729478 LOC102729478 VAV2 VAV2 LOC102732116 LOC102732116 ATP1B4 ATP1B4 NFATC1 NFATC1 PIK3CA PIK3CA FOS FOS PIK3CD PIK3CD
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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LOC102745211Follitropin subunit beta-like. (129 aa)
TSHBThyrotropin subunit beta. (138 aa)
PDE4DPhosphodiesterase. (811 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide. (176 aa)
GRIN3AGlutamate receptor ionotropic, NMDA 3A. (1115 aa)
CNGB3Cyclic nucleotide-gated cation channel beta-3. (780 aa)
HTR1F5-hydroxytryptamine receptor 1F. (366 aa)
LOC102736922Calmodulin-like; Belongs to the calmodulin family. (223 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
LOC102739131D(2) dopamine receptor-like; Belongs to the G-protein coupled receptor 1 family. (198 aa)
GRIN2DGlutamate receptor ionotropic, NMDA 2D. (840 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
LOC102727345Transcription factor SOX-9-like. (282 aa)
CALM3Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
MC2RAdrenocorticotropic hormone receptor. (297 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
RRASRas-related protein R-Ras. (218 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (66 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (366 aa)
GRIN2AGlutamate receptor ionotropic, NMDA 2A. (1308 aa)
LOC102744630D(2) dopamine receptor-like. (298 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
NPPANatriuretic peptides A. (150 aa)
PTGER2Prostaglandin E2 receptor EP2 subtype; Belongs to the G-protein coupled receptor 1 family. (353 aa)
PLCE1Phosphoinositide phospholipase C. (2299 aa)
VIPVIP peptides isoform X1. (170 aa)
PDE4BcAMP-specific 3',5'-cyclic phosphodiesterase 4B. (284 aa)
OXTROxytocin receptor; Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (389 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X2. (847 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
GRIN1Glutamate receptor ionotropic, NMDA 1 isoform X1. (943 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
HTR1D5-hydroxytryptamine receptor 1D. (377 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PTCH1Protein patched homolog 1. (1301 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
QPCTLGlutaminyl-peptide cyclotransferase-like protein isoform X1. (383 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (330 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (466 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
GHRLAppetite-regulating hormone isoform X1. (117 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (817 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
GPR150Probable G-protein coupled receptor 150. (399 aa)
ROCK2Rho-associated protein kinase 2. (850 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
RAP1BRas-related protein Rap-1b isoform X1. (184 aa)
LOC102736905Glutamate receptor 3-like. (89 aa)
GLI1Zinc finger protein GLI1 isoform X1. (1105 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
CNGA1cGMP-gated cation channel alpha-1. (694 aa)
PDE4APhosphodiesterase. (843 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
SSTSomatostatin. (116 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X1. (858 aa)
HTR1A5-hydroxytryptamine receptor 1A. (422 aa)
EDN2Endothelin-2. (179 aa)
PLD1Phospholipase. (1074 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
TNNI3Troponin I, cardiac muscle isoform X1. (211 aa)
LOC102742813Neuroendocrine secretory protein 55-like. (246 aa)
FFAR2Free fatty acid receptor 2 isoform X1; Belongs to the G-protein coupled receptor 1 family. (329 aa)
PLD2Phospholipase. (933 aa)
PDE3BPhosphodiesterase. (1180 aa)
ACOX3Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (700 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X1. (1591 aa)
HHIPHedgehog-interacting protein-like. (662 aa)
LOC102733505Glucose-dependent insulinotropic receptor-like; Belongs to the G-protein coupled receptor 1 family. (335 aa)
PDE10APhosphodiesterase. (794 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
NPYPro-neuropeptide Y. (97 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1483 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (574 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
POMCPro-opiomelanocortin. (153 aa)
LOC102726697Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
GRIA2Glutamate receptor 2 isoform X1. (940 aa)
HTR65-hydroxytryptamine receptor 6; Belongs to the G-protein coupled receptor 1 family. (440 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
DRD1D(1A) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (446 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
LOC102738071Calmodulin-like; Belongs to the calmodulin family. (113 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
LOC102740959Free fatty acid receptor 2-like; Belongs to the G-protein coupled receptor 1 family. (329 aa)
LOC102738651Afadin-like. (267 aa)
CHRM1Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (460 aa)
EP300Histone acetyltransferase p300. (2425 aa)
SSTR1Somatostatin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (391 aa)
LOC1027476305-hydroxytryptamine receptor 1B-like. (389 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (483 aa)
HCAR1LOW QUALITY PROTEIN: hydroxycarboxylic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (360 aa)
HCAR3LOW QUALITY PROTEIN: hydroxycarboxylic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (391 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like 4. (199 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102739372Seprase-like. (102 aa)
LOC102745028Endothelin-1 receptor-like. (178 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
LOC102748835Glucagon-like peptide 1 receptor-like; Belongs to the G-protein coupled receptor 2 family. (368 aa)
LOC102748045Proto-oncogene vav-like. (140 aa)
LOC102745857Phosphodiesterase. (503 aa)
LOC102726189Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (622 aa)
LOC102733954Calmodulin-like protein 4-like. (119 aa)
LOC102732257Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (469 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
CNGA2Cyclic nucleotide-gated olfactory channel. (659 aa)
LOC102742564Rho-associated protein kinase 2-like. (530 aa)
ARSIArylsulfatase I. (575 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha. (476 aa)
LOC102746549Glutamate receptor ionotropic, NMDA 2C-like. (348 aa)
ARAP3arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3. (1542 aa)
PPP1R1BProtein phosphatase 1 regulatory subunit 1B. (205 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
LHBLutropin subunit beta. (141 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV. (360 aa)
PPARAPeroxisome proliferator-activated receptor alpha. (303 aa)
LOC102730623Beta-2 adrenergic receptor-like. (418 aa)
HTR45-hydroxytryptamine receptor 4-like; Belongs to the G-protein coupled receptor 1 family. (388 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
ORAI1Calcium release-activated calcium channel protein 1. (302 aa)
LOC102735730Sodium/potassium-transporting ATPase subunit alpha-1-like; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (346 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (673 aa)
FXYD1FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (92 aa)
SOX10Transcription factor SOX-10. (469 aa)
NPR1Atrial natriuretic peptide receptor 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (242 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
GRIA1Glutamate receptor 1-like; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (528 aa)
CNGA4Cyclic nucleotide-gated cation channel alpha-4. (575 aa)
HTR1E5-hydroxytryptamine receptor 1E. (365 aa)
DRD5D(1B) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (432 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
GCGGlucagon isoform X1. (180 aa)
CREBBPCREB-binding protein-like. (1411 aa)
NPY1RNeuropeptide Y receptor type 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
ATP2A3Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (604 aa)
LOC102729478Endothelin-1 receptor-like; Belongs to the G-protein coupled receptor 1 family. (253 aa)
VAV2Guanine nucleotide exchange factor VAV2. (357 aa)
LOC102732116Follicle-stimulating hormone receptor-like. (181 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (360 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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