STRINGSTRING
XCL1 XCL1 GNG2 GNG2 CXCL14 CXCL14 LOC102736516 LOC102736516 LOC102734017 LOC102734017 LOC102726694 LOC102726694 NFKB1 NFKB1 PRKCZ PRKCZ NFKBIA NFKBIA LOC102740357 LOC102740357 ITK ITK GNG3 GNG3 CXCL6 CXCL6 PF4 PF4 PPBP PPBP IL8 IL8 FOXO3 FOXO3 ADCY6 ADCY6 PIK3R3 PIK3R3 CSDE1 CSDE1 LPXN LPXN NRAS NRAS CXCL12 CXCL12 LOC102726446 LOC102726446 KRAS KRAS GNGT1 GNGT1 GNG11 GNG11 LOC102726697 LOC102726697 LOC102734862 LOC102734862 GRK6 GRK6 GNB5 GNB5 GNG10 GNG10 SRC SRC GNB2 GNB2 CCL25 CCL25 CCL24 CCL24 CCL26 CCL26 SHC1 SHC1 PREX1 PREX1 CCR4 CCR4 VAV3 VAV3 SHC4 SHC4 CEP152 CEP152 PRKACB PRKACB GNG5 GNG5 JAK2 JAK2 GNAI2 GNAI2 GRK7 GRK7 GNB3 GNB3 AKT1 AKT1 WAS WAS ERAS ERAS LOC102745161 LOC102745161 STAT5B STAT5B GRK1 GRK1 GNG13 GNG13 CCL21 CCL21 IKBKG IKBKG NFKBIB NFKBIB PAK1 PAK1 ROCK2 ROCK2 LOC102745475 LOC102745475 AKT3 AKT3 RAP1B RAP1B RAF1 RAF1 STAT2 STAT2 CHUK CHUK XCR1 XCR1 PTRHD1 PTRHD1 GNGT2 GNGT2 CXCR5 CXCR5 CCL13 CCL13 CCL8 CCL8 CCL7 CCL7 CCL1 CCL1 GSK3B GSK3B RAC2 RAC2 LOC102747594 LOC102747594 CXCL13 CXCL13 MAPK1 MAPK1 ADRBK1 ADRBK1 IKBKB IKBKB NCF1 NCF1 TIAM1 TIAM1 CXCL9 CXCL9 CXCL10 CXCL10 LOC102740920 LOC102740920 CXCL11 CXCL11 LOC102735415 LOC102735415 CDC42 CDC42 ADCY9 ADCY9 LOC102750030 LOC102750030 LOC102751021 LOC102751021 LOC102747754 LOC102747754 LOC102731864 LOC102731864 LOC102726881 LOC102726881 LOC102742576 LOC102742576 CXCR6 CXCR6 LOC102731038 LOC102731038 LOC102748045 LOC102748045 CCR9 CCR9 PRKACA PRKACA LOC102733354 LOC102733354 LOC102748833 LOC102748833 LOC102742564 LOC102742564 CCR5 CCR5 CCR1 CCR1 CCL20 CCL20 STAT3 STAT3 CCR6 CCR6 LOC102748147 LOC102748147 CCR3 CCR3 LOC102740654 LOC102740654 CCL16 CCL16 GSK3A GSK3A GNB4 GNB4 CCL14 CCL14 LOC102730715 LOC102730715 LOC102727172 LOC102727172 JAK3 JAK3 CXCR3 CXCR3 CX3CL1 CX3CL1 LOC102736228 LOC102736228 CCL17 CCL17 LOC102735431 LOC102735431 LOC102747137 LOC102747137 RUFY4 RUFY4 CRKL CRKL GNG8 GNG8 RASGRP2 RASGRP2 LOC102746012 LOC102746012 PIK3CD PIK3CD LOC102736718 LOC102736718 PIK3CA PIK3CA CCR7 CCR7 GNG4 GNG4 VAV2 VAV2 PLCB3 PLCB3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
XCL1Lymphotactin. (112 aa)
GNG2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
CXCL14c-X-C motif chemokine 14. (99 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
LOC102734017c-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (351 aa)
LOC102726694C-C motif chemokine. (121 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
LOC102740357Cell division control protein 42 homolog. (191 aa)
ITKTyrosine-protein kinase. (486 aa)
GNG3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CXCL6C-X-C motif chemokine. (113 aa)
PF4C-X-C motif chemokine. (106 aa)
PPBPLOW QUALITY PROTEIN: platelet basic protein. (119 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
FOXO3Forkhead box protein O3. (672 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
LPXNLeupaxin; Belongs to the paxillin family. (386 aa)
NRASGTPase NRas. (189 aa)
CXCL12Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
KRASGTPase KRas isoform X2. (188 aa)
GNGT1Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
GNG11Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
LOC102726697Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
GRK6G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (582 aa)
GNB5Guanine nucleotide-binding protein subunit beta-5. (345 aa)
GNG10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
SRCTyrosine-protein kinase. (536 aa)
GNB2Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1. (340 aa)
CCL25LOW QUALITY PROTEIN: c-C motif chemokine 25. (146 aa)
CCL24c-C motif chemokine 24. (119 aa)
CCL26C-C motif chemokine. (94 aa)
SHC1SHC-transforming protein 1 isoform X2. (583 aa)
PREX1Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein. (1642 aa)
CCR4c-C chemokine receptor type 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X2. (847 aa)
SHC4SHC-transforming protein 4. (630 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
JAK2Tyrosine-protein kinase. (952 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
GRK7G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (553 aa)
GNB3Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
WASwiskott-Aldrich syndrome protein. (501 aa)
ERASGTPase ERas. (233 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
GRK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (564 aa)
GNG13Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
CCL21c-C motif chemokine 21. (137 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
NFKBIBNF-kappa-B inhibitor beta isoform X2. (354 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ROCK2Rho-associated protein kinase 2. (850 aa)
LOC102745475Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like isoform X1. (340 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
RAP1BRas-related protein Rap-1b isoform X1. (184 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
STAT2Signal transducer and activator of transcription. (854 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
XCR1Chemokine XC receptor 1; Belongs to the G-protein coupled receptor 1 family. (331 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
GNGT2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
CXCR5c-X-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (377 aa)
CCL13C-C motif chemokine. (98 aa)
CCL8c-C motif chemokine 8. (99 aa)
CCL7LOW QUALITY PROTEIN: c-C motif chemokine 7. (99 aa)
CCL1c-C motif chemokine 1. (94 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
LOC102747594c-X-C chemokine receptor type 4-like; Belongs to the G-protein coupled receptor 1 family. (353 aa)
CXCL13c-X-C motif chemokine 13. (110 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
ADRBK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (647 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
NCF1Neutrophil cytosol factor 1. (380 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X1. (1591 aa)
CXCL9C-X-C motif chemokine. (126 aa)
CXCL10C-X-C motif chemokine. (98 aa)
LOC102740920C-C motif chemokine. (91 aa)
CXCL11c-X-C motif chemokine 11. (100 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
CDC42Cell division control protein 42 homolog. (160 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
LOC102750030Protein-tyrosine kinase 2-beta-like. (125 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102747754Fractalkine-like. (221 aa)
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
LOC102726881Breast cancer anti-estrogen resistance protein 1-like. (695 aa)
LOC102742576C-X-C motif chemokine. (107 aa)
CXCR6c-X-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (341 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
LOC102748045Proto-oncogene vav-like. (140 aa)
CCR9c-C chemokine receptor type 9; Belongs to the G-protein coupled receptor 1 family. (369 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LOC102733354c-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (356 aa)
LOC102748833Tyrosine-protein kinase. (375 aa)
LOC102742564Rho-associated protein kinase 2-like. (530 aa)
CCR5c-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
CCR1c-C chemokine receptor type 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
CCL20C-C motif chemokine. (89 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
CCR6c-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (375 aa)
LOC102748147Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
CCR3c-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (359 aa)
LOC102740654Phosphoinositide 3-kinase regulatory subunit 5-like. (111 aa)
CCL16c-C motif chemokine 16. (108 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (419 aa)
GNB4Guanine nucleotide-binding protein subunit beta-4. (340 aa)
CCL14c-C motif chemokine 14. (96 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
LOC102727172Engulfment and cell motility protein 1-like. (247 aa)
JAK3Tyrosine-protein kinase. (1139 aa)
CXCR3c-X-C chemokine receptor type 3; Belongs to the G-protein coupled receptor 1 family. (364 aa)
CX3CL1Fractalkine. (181 aa)
LOC102736228Partitioning defective 3 homolog. (214 aa)
CCL17c-C motif chemokine 17. (99 aa)
LOC102735431C-C motif chemokine. (93 aa)
LOC102747137G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (140 aa)
RUFY4RUN and FYVE domain-containing protein 4-like. (563 aa)
CRKLCrk-like protein. (303 aa)
GNG8Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
RASGRP2RAS guanyl-releasing protein 2 isoform X2. (608 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
LOC102736718Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CCR7c-C chemokine receptor type 7; Belongs to the G-protein coupled receptor 1 family. (390 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
VAV2Guanine nucleotide exchange factor VAV2. (357 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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