(80 nodes) NF-kappa B signaling pathway network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRADD	Tumor necrosis factor receptor type 1-associated DEATH domain protein. (312 aa)
	CARD14	LOW QUALITY PROTEIN: caspase recruitment domain family, member 14. (510 aa)
	LOC102740172	Lipopolysaccharide-binding protein-like. (97 aa)
	LOC102742576	C-X-C motif chemokine. (107 aa)
	TRIM47	Tripartite motif-containing protein 47-like. (401 aa)
	LOC102744110	Tumor necrosis factor ligand superfamily member 11-like; Belongs to the tumor necrosis factor family. (188 aa)
	LOC102748833	Tyrosine-protein kinase. (375 aa)
	NFKB2	Nuclear factor NF-kappa-B p100 subunit. (900 aa)
	LOC102741463	Vascular cell adhesion protein 1-like. (318 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
	BIRC2	Baculoviral IAP repeat-containing protein 2-like. (619 aa)
	GADD45B	Growth arrest and DNA damage-inducible protein GADD45 beta isoform X2. (160 aa)
	LOC102740348	Tumor necrosis factor ligand superfamily member 13B-like. (164 aa)
	TNFSF14	Tumor necrosis factor ligand superfamily member 14. (241 aa)
	TRIM65	Tripartite motif-containing protein 65. (381 aa)
	LOC102737749	Transcription factor RelB-like. (167 aa)
	COIL	Coilin. (577 aa)
	BIRC3	Baculoviral IAP repeat-containing protein 3. (604 aa)
	GADD45G	Growth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
	LOC102732223	Toll/interleukin-1 receptor domain-containing adapter protein-like. (226 aa)
	ICAM1	Intercellular adhesion molecule 1. (533 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (260 aa)
	LOC102743326	Tumor necrosis factor receptor superfamily member EDAR-like. (298 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
	LOC102735415	Phosphoinositide phospholipase C. (309 aa)
	LOC102730789	TNF receptor-associated factor 3-like. (295 aa)
	PARP1	Poly [ADP-ribose] polymerase. (686 aa)
	LOC102740611	TNF receptor-associated factor. (490 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
	IKBKB	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
	LOC102728857	Probable ATP-dependent RNA helicase DDX58-like. (294 aa)
	LOC102729256	TNF receptor-associated factor 3-like. (283 aa)
	XIAP	E3 ubiquitin-protein ligase XIAP-like isoform X1. (497 aa)
	LOC102740606	SUMO-conjugating enzyme UBC9-like; Belongs to the ubiquitin-conjugating enzyme family. (123 aa)
	PIDD	P53-induced protein with a death domain. (916 aa)
	CCL13	C-C motif chemokine. (98 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
	CARD10	Caspase recruitment domain-containing protein 10. (1029 aa)
	BCL10	B-cell lymphoma/leukemia 10 isoform X1. (233 aa)
	LOC102728244	Interleukin-1 receptor-associated kinase 1-like. (299 aa)
	BCL2A1	Bcl-2-related protein A1. (174 aa)
	CD40	Tumor necrosis factor receptor superfamily member 5. (272 aa)
	IKBKG	NF-kappa-B essential modulator isoform X2. (419 aa)
	CCL21	c-C motif chemokine 21. (137 aa)
	PIAS4	E3 SUMO-protein ligase PIAS4. (503 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
	LTA	Lymphotoxin-alpha; Belongs to the tumor necrosis factor family. (204 aa)
	LTB	Lymphotoxin-beta isoform X1; Belongs to the tumor necrosis factor family. (247 aa)
	CSNK2B	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
	LY6G5B	Lymphocyte antigen 6 complex locus protein G5b. (195 aa)
	EDARADD	ectodysplasin-A receptor-associated adapter protein. (205 aa)
	TNFRSF1A	Tumor necrosis factor receptor superfamily member 1A. (358 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	LY96	Lymphocyte antigen 96 isoform X1. (160 aa)
	TICAM2	TIR domain-containing adapter molecule 2. (238 aa)
	TMED7	Transmembrane emp24 domain-containing protein 7. (224 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
	ERC1	ELKS/Rab6-interacting/CAST family member 1 isoform X1. (1120 aa)
	LTBR	Tumor necrosis factor receptor superfamily member 3 isoform X1. (421 aa)
	MAP3K14	Mitogen-activated protein kinase kinase kinase 14. (955 aa)
	GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
	EDA	ectodysplasin-A isoform X1; Belongs to the tumor necrosis factor family. (390 aa)
	TNFAIP3	Tumor necrosis factor alpha-induced protein 3. (790 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
	TAB3	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3-like. (717 aa)
	LAT	Linker for activation of T-cells family member 1. (256 aa)
	ZAP70	Tyrosine-protein kinase. (616 aa)
	EDA2R	Tumor necrosis factor receptor superfamily member 27 isoform X1. (299 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit. (254 aa)
	NFKBIA	NF-kappa-B inhibitor alpha isoform X2. (314 aa)
	KIAA1468	lisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X1. (1214 aa)
	PTGS2	Prostaglandin G/H synthase 2. (470 aa)
	IRAK4	Interleukin-1 receptor-associated kinase 4 isoform X1. (459 aa)
	CARD11	Caspase recruitment domain-containing protein 11. (1146 aa)
	IL8	Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
	LOC102750498	Casein kinase II subunit alpha-like isoform X1; Belongs to the protein kinase superfamily. (391 aa)
	EDAR	Tumor necrosis factor receptor superfamily member EDAR. (238 aa)
	VCAM1	Vascular cell adhesion protein 1. (377 aa)
	CXCL12	Stromal cell-derived factor 1 isoform X1; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
	BCL2L1	Bcl-2-like protein 1 isoform X1. (233 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	GADD45A	A0A2U3YJR1	A0A2U3XVK7	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1.	0.470
ATM	IKBKG	A0A2U3YJR1	A0A2U3Y6Q4	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	NF-kappa-B essential modulator isoform X2.	0.721
ATM	LOC102740606	A0A2U3YJR1	A0A2U3YE51	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	SUMO-conjugating enzyme UBC9-like; Belongs to the ubiquitin-conjugating enzyme family.	0.576
ATM	PARP1	A0A2U3YJR1	A0A2U3YK56	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Poly [ADP-ribose] polymerase.	0.668
ATM	PIAS4	A0A2U3YJR1	A0A2U3Y4Z2	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	E3 SUMO-protein ligase PIAS4.	0.714
ATM	PIDD	A0A2U3YJR1	A0A2U3YDT1	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	P53-induced protein with a death domain.	0.923
BCL10	BIRC2	A0A2U3YB77	A0A2U3Z1X8	B-cell lymphoma/leukemia 10 isoform X1.	Baculoviral IAP repeat-containing protein 2-like.	0.444
BCL10	BIRC3	A0A2U3YB77	A0A2U3YVF5	B-cell lymphoma/leukemia 10 isoform X1.	Baculoviral IAP repeat-containing protein 3.	0.444
BCL10	CARD10	A0A2U3YB77	A0A2U3YBM8	B-cell lymphoma/leukemia 10 isoform X1.	Caspase recruitment domain-containing protein 10.	0.752
BCL10	CARD11	A0A2U3YB77	A0A2U3XF29	B-cell lymphoma/leukemia 10 isoform X1.	Caspase recruitment domain-containing protein 11.	0.996
BCL10	CARD14	A0A2U3YB77	A0A2U3Z995	B-cell lymphoma/leukemia 10 isoform X1.	LOW QUALITY PROTEIN: caspase recruitment domain family, member 14.	0.752
BCL10	CHUK	A0A2U3YB77	A0A2U3YBY3	B-cell lymphoma/leukemia 10 isoform X1.	Inhibitor of nuclear factor kappa-B kinase subunit alpha.	0.955
BCL10	IKBKB	A0A2U3YB77	A0A2U3YJI5	B-cell lymphoma/leukemia 10 isoform X1.	Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.	0.965
BCL10	IKBKG	A0A2U3YB77	A0A2U3Y6Q4	B-cell lymphoma/leukemia 10 isoform X1.	NF-kappa-B essential modulator isoform X2.	0.984
BCL10	LOC102728857	A0A2U3YB77	A0A2U3YH50	B-cell lymphoma/leukemia 10 isoform X1.	Probable ATP-dependent RNA helicase DDX58-like.	0.402
BCL10	LOC102729256	A0A2U3YB77	A0A2U3YGG7	B-cell lymphoma/leukemia 10 isoform X1.	TNF receptor-associated factor 3-like.	0.425
BCL10	LOC102730789	A0A2U3YB77	A0A2U3YKH7	B-cell lymphoma/leukemia 10 isoform X1.	TNF receptor-associated factor 3-like.	0.425
BCL10	LOC102737749	A0A2U3YB77	A0A2U3YXH0	B-cell lymphoma/leukemia 10 isoform X1.	Transcription factor RelB-like.	0.765
BCL10	NFKB1	A0A2U3YB77	A0A2U3XMD9	B-cell lymphoma/leukemia 10 isoform X1.	Nuclear factor NF-kappa-B p105 subunit.	0.681
BCL10	NFKBIA	A0A2U3YB77	A0A2U3XLC0	B-cell lymphoma/leukemia 10 isoform X1.	NF-kappa-B inhibitor alpha isoform X2.	0.599