STRINGSTRING
CDKN1A CDKN1A FOXO1 FOXO1 STAT3 STAT3 INS INS LOC102730318 LOC102730318 LOC102731850 LOC102731850 GADD45B GADD45B G6PC2 G6PC2 RNF6 RNF6 HOMER3 HOMER3 LOC102735530 LOC102735530 SNAPIN SNAPIN TGFB3 TGFB3 TGFB1 TGFB1 LOC102736516 LOC102736516 GADD45G GADD45G LOC102749105 LOC102749105 SGK1 SGK1 CREBBP CREBBP FOXO6 FOXO6 PIK3CA PIK3CA PIK3CD PIK3CD CDKN2A CDKN2A CDKN2B CDKN2B SOS1 SOS1 LOC102740618 LOC102740618 TSSK2 TSSK2 LDLRAD4 LDLRAD4 LOC102737920 LOC102737920 S1PR4 S1PR4 CCND1 CCND1 TSSK6 TSSK6 PRMT1 PRMT1 ATM ATM IKBKB IKBKB MAPK1 MAPK1 SETD7 SETD7 CCNG2 CCNG2 LOC102746004 LOC102746004 BCL6B BCL6B FOXJ3 FOXJ3 IL6 IL6 LOC102748583 LOC102748583 PRKAG2 PRKAG2 PMEPA1 PMEPA1 PRMT8 PRMT8 CHUK CHUK CDKN2D CDKN2D CCNB2 CCNB2 RAF1 RAF1 AGAP2 AGAP2 MDM2 MDM2 SLC35E3 SLC35E3 AKT3 AKT3 LOC102749673 LOC102749673 PRKAB1 PRKAB1 GABARAP GABARAP SLC2A4 SLC2A4 CCNB1 CCNB1 MAP2K2 MAP2K2 LOC102726446 LOC102726446 PLK2 PLK2 CDK3 CDK3 S1PR1 S1PR1 RASGEF1A RASGEF1A PLK3 PLK3 NRAS NRAS CSDE1 CSDE1 CDK2 CDK2 PIK3R3 PIK3R3 PLK4 PLK4 REM1 REM1 KRAS KRAS PRKAG1 PRKAG1 LOC102751021 LOC102751021 LOC102734169 LOC102734169 TSSK4 TSSK4 LOC102748341 LOC102748341 MAPK11 MAPK11 LOC102727190 LOC102727190 PCK1 PCK1 LOC102736146 LOC102736146 LOC102735556 LOC102735556 FOXO3 FOXO3 MAPK10 MAPK10 MAP2K1 MAP2K1 GEM GEM EP300 EP300 PLK1 PLK1 IGF1 IGF1 NLK NLK GRAP GRAP HOMER1 HOMER1 RRAD RRAD LOC102726691 LOC102726691 GABARAPL1 GABARAPL1 PTEN PTEN CDKN1B CDKN1B SOD2 SOD2 PRKAA1 PRKAA1 TNFSF10 TNFSF10 TGFBR2 TGFBR2 IL10 IL10 TSSK3 TSSK3 RASL11B RASL11B SGK3 SGK3 SGK2 SGK2 SMAD4 SMAD4 LOC102745146 LOC102745146 LOC102745453 LOC102745453 STK4 STK4 MAPK12 MAPK12 GADD45A GADD45A IRS1 IRS1 RNF111 RNF111 GRM1 GRM1 RAG2 RAG2 RAG1 RAG1 ATG12 ATG12 BCL6 BCL6 FOXO4 FOXO4 FASLG FASLG SUCO SUCO PRMT3 PRMT3 MAPK8 MAPK8 FOXJ2 FOXJ2 TGFB2 TGFB2 IGF1R IGF1R AKT1 AKT1 ERAS ERAS LOC102745161 LOC102745161 G6PC G6PC PCK2 PCK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
FOXO1Forkhead box protein O1-like. (418 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
LOC102731850Tyrosine-protein kinase receptor. (757 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta isoform X2. (160 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (356 aa)
RNF6E3 ubiquitin-protein ligase RNF6 isoform X1. (683 aa)
HOMER3Homer protein homolog 3 isoform X1. (359 aa)
LOC102735530ras-GEF domain-containing family member 1B-like. (472 aa)
SNAPINSNARE-associated protein Snapin. (137 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
LOC102749105Transmembrane protein 232-like. (368 aa)
SGK1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (495 aa)
CREBBPCREB-binding protein-like. (1411 aa)
FOXO6Forkhead box protein O6. (397 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoforms 1/2/3. (152 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
SOS1Son of sevenless homolog 1-like. (281 aa)
LOC102740618Testis-specific serine/threonine-protein kinase 1-like; Belongs to the protein kinase superfamily. (367 aa)
TSSK2Testis-specific serine/threonine-protein kinase 2; Belongs to the protein kinase superfamily. (361 aa)
LDLRAD4Low-density lipoprotein receptor class A domain-containing protein 4 isoform X1. (269 aa)
LOC102737920GRB2-related adapter protein-like. (100 aa)
S1PR4Sphingosine 1-phosphate receptor 4 isoform X1. (385 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
TSSK6Testis-specific serine/threonine-protein kinase 6; Belongs to the protein kinase superfamily. (273 aa)
PRMT1Protein arginine N-methyltransferase 1 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
SETD7Histone-lysine N-methyltransferase SETD7. (307 aa)
CCNG2cyclin-G2 isoform X1; Belongs to the cyclin family. (343 aa)
LOC102746004Bcl-2-like protein 11-like isoform X2. (140 aa)
BCL6BB-cell CLL/lymphoma 6 member B protein. (476 aa)
FOXJ3Forkhead box protein J3. (588 aa)
IL6Interleukin-6 isoform X1. (212 aa)
LOC1027485835'-AMP-activated protein kinase subunit gamma-2-like. (129 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2-like isoform X2. (327 aa)
PMEPA1Transmembrane prostate androgen-induced protein. (237 aa)
PRMT8Protein arginine N-methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (334 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D isoform X2. (166 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (299 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
AGAP2arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1. (1189 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
SLC35E3Solute carrier family 35 member E3. (313 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
LOC102749673Insulin-like growth factor 1 receptor-like. (143 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
GABARAPGamma-aminobutyric acid receptor-associated protein. (117 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (427 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
PLK2Serine/threonine-protein kinase PLK2; Belongs to the protein kinase superfamily. (418 aa)
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
S1PR1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
RASGEF1Aras-GEF domain-containing family member 1A. (480 aa)
PLK3Serine/threonine-protein kinase PLK. (698 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
PLK4Serine/threonine-protein kinase PLK4 isoform X1. (970 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
KRASGTPase KRas isoform X2. (188 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (298 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102734169Gamma-aminobutyric acid receptor-associated protein-like 2-like. (117 aa)
TSSK4Testis-specific serine/threonine-protein kinase 4 isoform X1. (339 aa)
LOC102748341Serine/threonine-protein kinase PLK2-like. (267 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102727190Serine/threonine-protein kinase STK11-like. (545 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP] isoform X2. (622 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
FOXO3Forkhead box protein O3. (672 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
EP300Histone acetyltransferase p300. (2425 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
NLKSerine/threonine-protein kinase NLK. (507 aa)
GRAPGRB2-related adapter protein. (210 aa)
HOMER1Homer protein homolog 1 isoform X1. (354 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
LOC102726691BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X2. (194 aa)
GABARAPL1Gamma-aminobutyric acid receptor-associated protein-like 1 isoform X1. (117 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
TNFSF10Tumor necrosis factor ligand superfamily member 10; Belongs to the tumor necrosis factor family. (245 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
IL10Interleukin-10. (178 aa)
TSSK3Testis-specific serine/threonine-protein kinase 3 isoform X1. (268 aa)
RASL11BRas-like protein family member 11B. (248 aa)
SGK3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
SGK2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (367 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
LOC102745146Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (173 aa)
LOC102745453SUN domain-containing ossification factor-like. (283 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
IRS1Insulin receptor substrate 1-like isoform X1. (1236 aa)
RNF111E3 ubiquitin-protein ligase Arkadia isoform X1. (994 aa)
GRM1Metabotropic glutamate receptor 1. (887 aa)
RAG2V(D)J recombination-activating protein 2. (527 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa)
BCL6B-cell lymphoma 6 protein. (706 aa)
FOXO4Forkhead box protein O4 isoform X1. (506 aa)
FASLGTumor necrosis factor ligand superfamily member 6. (130 aa)
SUCOSUN domain-containing ossification factor. (983 aa)
PRMT3Protein arginine N-methyltransferase 3 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (529 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
FOXJ2Forkhead box protein J2. (572 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
IGF1RInsulin-like growth factor 1 receptor-like. (291 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
ERASGTPase ERas. (233 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X2. (640 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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