STRINGSTRING
ASAH1 ASAH1 KRAS KRAS PPP2R3A PPP2R3A LOC102726446 LOC102726446 S1PR1 S1PR1 CERS2 CERS2 NRAS NRAS CSDE1 CSDE1 PIK3R3 PIK3R3 SMPD2 SMPD2 MAPK10 MAPK10 MAP2K1 MAP2K1 GNA12 GNA12 LOC102740567 LOC102740567 PPP2CB PPP2CB PRKCZ PRKCZ NFKB1 NFKB1 PTEN PTEN LOC102738979 LOC102738979 CERS6 CERS6 LOC102726697 LOC102726697 LOC102734862 LOC102734862 AADAC AADAC AADACL2 AADACL2 CERS4 CERS4 CERS5 CERS5 MAPK12 MAPK12 BDKRB2 BDKRB2 PPP2R5D PPP2R5D PPP2R2A PPP2R2A GNAI2 GNAI2 TNFRSF1A TNFRSF1A MAPK8 MAPK8 AKT1 AKT1 ERAS ERAS TNF TNF MAP2K2 MAP2K2 TP53 TP53 ROCK2 ROCK2 AKT3 AKT3 PPP2R5C PPP2R5C RAF1 RAF1 SGMS1 SGMS1 S1PR5 S1PR5 ASAH2B ASAH2B DEGS2 DEGS2 TRADD TRADD SGPP1 SGPP1 IFITM3 IFITM3 ACER2 ACER2 FCER1A FCER1A PLD1 PLD1 RAC2 RAC2 PLD2 PLD2 KNG1 KNG1 PPP2R2C PPP2R2C MAPK1 MAPK1 PPP2R5A PPP2R5A FCER1G FCER1G S1PR4 S1PR4 PPP2R5E PPP2R5E SPHK2 SPHK2 PIK3CD PIK3CD PIK3CA PIK3CA PLCB3 PLCB3 S1PR2 S1PR2 MS4A2 MS4A2 LOC102736516 LOC102736516 LOC102732031 LOC102732031 LOC102730087 LOC102730087 SGPL1 SGPL1 SMPD1 SMPD1 LOC102738241 LOC102738241 PPP2R3B PPP2R3B LOC102730715 LOC102730715 ACER1 ACER1 LOC102729504 LOC102729504 OPRD1 OPRD1 LOC102730629 LOC102730629 LOC102742564 LOC102742564 CTSD CTSD LOC102735556 LOC102735556 LOC102751101 LOC102751101 LOC102736146 LOC102736146 MAPK11 MAPK11 LOC102745333 LOC102745333 LOC102740880 LOC102740880 LOC102751021 LOC102751021 LOC102734861 LOC102734861
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ASAH1Acid ceramidase; Belongs to the acid ceramidase family. (395 aa)
KRASGTPase KRas isoform X2. (188 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1. (1153 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
S1PR1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
CERS2Ceramide synthase 2. (380 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
SMPD2Sphingomyelin phosphodiesterase 2. (422 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12 isoform X1. (305 aa)
LOC102740567Adenosine receptor A1; Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (114 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LOC102738979Adenosine receptor A3-like. (173 aa)
CERS6Ceramide synthase 6. (375 aa)
LOC102726697Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
AADACArylacetamide deacetylase. (399 aa)
AADACL2LOW QUALITY PROTEIN: arylacetamide deacetylase-like 2. (400 aa)
CERS4Ceramide synthase 4. (332 aa)
CERS5Ceramide synthase 5. (392 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
BDKRB2B2 bradykinin receptor; Belongs to the G-protein coupled receptor 1 family. (392 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (676 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
ERASGTPase ERas. (233 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ROCK2Rho-associated protein kinase 2. (850 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
SGMS1Phosphatidylcholine:ceramide cholinephosphotransferase 1. (413 aa)
S1PR5Sphingosine 1-phosphate receptor 5. (398 aa)
ASAH2BNeutral ceramidase. (423 aa)
DEGS2Sphingolipid delta(4)-desaturase/C4-hydroxylase DES2. (323 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (312 aa)
SGPP1Sphingosine-1-phosphate phosphatase 1. (445 aa)
IFITM3Interferon-induced transmembrane protein 3. (146 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (125 aa)
FCER1AHigh affinity immunoglobulin epsilon receptor subunit alpha. (264 aa)
PLD1Phospholipase. (1074 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
PLD2Phospholipase. (933 aa)
KNG1Kininogen-1 isoform X1. (652 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform. (231 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (94 aa)
S1PR4Sphingosine 1-phosphate receptor 4 isoform X1. (385 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
SPHK2Sphingosine kinase 2 isoform X1. (656 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
S1PR2Sphingosine 1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (352 aa)
MS4A2High affinity immunoglobulin epsilon receptor subunit beta. (242 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
LOC102732031Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (407 aa)
LOC102730087Ceramide synthase 1-like. (99 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
LOC102738241Mitogen-activated protein kinase kinase kinase 5-like. (795 aa)
PPP2R3BSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta. (596 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (263 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
OPRD1Delta-type opioid receptor-like; Belongs to the G-protein coupled receptor 1 family. (288 aa)
LOC102730629Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa)
LOC102742564Rho-associated protein kinase 2-like. (530 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (410 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
LOC102751101Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (178 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102745333Serine palmitoyltransferase 2-like. (211 aa)
LOC102740880Nitric oxide synthase, endothelial-like. (619 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102734861BH3-interacting domain death agonist-like. (83 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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