STRINGSTRING
DNM3 DNM3 AKT1 AKT1 ERAS ERAS AGPAT1 AGPAT1 MAP2K2 MAP2K2 KITLG KITLG LOC102730047 LOC102730047 LOC102729246 LOC102729246 AKT3 AKT3 RAF1 RAF1 LPAR6 LPAR6 PTRHD1 PTRHD1 AVPR1B AVPR1B RAPGEF4 RAPGEF4 FCER1A FCER1A PLD1 PLD1 CYTH4 CYTH4 LPAR4 LPAR4 LOC102742813 LOC102742813 PLD2 PLD2 ARF1 ARF1 MAPK1 MAPK1 LOC102750470 LOC102750470 RALGDS RALGDS DNM1 DNM1 LOC102735415 LOC102735415 FCER1G FCER1G RRAS RRAS LPAR2 LPAR2 ADCY9 ADCY9 GRM4 GRM4 SPHK2 SPHK2 CYTH2 CYTH2 LOC102746012 LOC102746012 PIK3CD PIK3CD PIK3CA PIK3CA PLCB3 PLCB3 MS4A2 MS4A2 PDGFB PDGFB DGKQ DGKQ LOC102736516 LOC102736516 CYTH3 CYTH3 PDGFRA PDGFRA LOC102734017 LOC102734017 RUFY4 RUFY4 DGKH DGKH LOC102742631 LOC102742631 DGKE DGKE LOC102730715 LOC102730715 LOC102736541 LOC102736541 LOC102740060 LOC102740060 LOC102740654 LOC102740654 INS INS AVPR1A AVPR1A AGT AGT GRM2 GRM2 LOC102733354 LOC102733354 LOC102731038 LOC102731038 LOC102742177 LOC102742177 PPAP2C PPAP2C LOC102751021 LOC102751021 LOC102750030 LOC102750030 PDGFC PDGFC KRAS KRAS MRAS MRAS LOC102726446 LOC102726446 PIP5K1A PIP5K1A NRAS NRAS CSDE1 CSDE1 DGKA DGKA PIK3R3 PIK3R3 GRM8 GRM8 RHEBL1 RHEBL1 LOC102742552 LOC102742552 ADCY6 ADCY6 ARF6 ARF6 MAP2K1 MAP2K1 IL8 IL8 GNA12 GNA12 ZNF408 ZNF408 LOC102739066 LOC102739066 DGKB DGKB PLA2G4D PLA2G4D PTGFR PTGFR PPAP2A PPAP2A LPAR1 LPAR1 PIP5K1B PIP5K1B SHC1 SHC1 GAB1 GAB1 F2R F2R MTOR MTOR PTPN11 PTPN11 GRM1 GRM1 RALA RALA JMJD7 JMJD7 SHC4 SHC4 CEP152 CEP152
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DNM3Dynamin-3 isoform X2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (865 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
ERASGTPase ERas. (233 aa)
AGPAT11-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (287 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
LOC102730047Tuberin-like. (353 aa)
LOC102729246Diacylglycerol kinase delta-like. (376 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
LPAR6Lysophosphatidic acid receptor 6; Belongs to the G-protein coupled receptor 1 family. (344 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X1. (858 aa)
FCER1AHigh affinity immunoglobulin epsilon receptor subunit alpha. (264 aa)
PLD1Phospholipase. (1074 aa)
CYTH4Cytohesin-4. (394 aa)
LPAR4Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
LOC102742813Neuroendocrine secretory protein 55-like. (246 aa)
PLD2Phospholipase. (933 aa)
ARF1ADP-ribosylation factor 1; Belongs to the small GTPase superfamily. Arf family. (181 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
LOC102750470ADP-ribosylation factor 2-like isoform X2; Belongs to the small GTPase superfamily. Arf family. (181 aa)
RALGDSRal guanine nucleotide dissociation stimulator. (518 aa)
DNM1Dynamin-1 isoform X2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (94 aa)
RRASRas-related protein R-Ras. (218 aa)
LPAR2Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
GRM4Metabotropic glutamate receptor 4. (555 aa)
SPHK2Sphingosine kinase 2 isoform X1. (656 aa)
CYTH2Cytohesin-2 isoform X1. (399 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
MS4A2High affinity immunoglobulin epsilon receptor subunit beta. (242 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
DGKQDiacylglycerol kinase. (913 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
CYTH3Cytohesin-3. (270 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1090 aa)
LOC102734017c-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (351 aa)
RUFY4RUN and FYVE domain-containing protein 4-like. (563 aa)
DGKHDiacylglycerol kinase. (1084 aa)
LOC102742631Diacylglycerol kinase delta-like. (110 aa)
DGKEDiacylglycerol kinase. (514 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
LOC102736541Cytohesin-1-like. (251 aa)
LOC102740060Ral guanine nucleotide dissociation stimulator-like. (256 aa)
LOC102740654Phosphoinositide 3-kinase regulatory subunit 5-like. (111 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. (381 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
GRM2Metabotropic glutamate receptor 2 isoform X1. (871 aa)
LOC102733354c-X-C chemokine receptor type 2-like; Belongs to the G-protein coupled receptor 1 family. (356 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
LOC102742177Mast/stem cell growth factor receptor Kit-like. (217 aa)
PPAP2CLipid phosphate phosphohydrolase 2-like. (288 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102750030Protein-tyrosine kinase 2-beta-like. (125 aa)
PDGFCPlatelet-derived growth factor C-like; Belongs to the PDGF/VEGF growth factor family. (345 aa)
KRASGTPase KRas isoform X2. (188 aa)
MRASRas-related protein M-Ras. (208 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
PIP5K1APhosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1. (549 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
DGKADiacylglycerol kinase. (733 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
GRM8Metabotropic glutamate receptor 8 isoform X2. (908 aa)
RHEBL1GTPase RhebL1. (183 aa)
LOC102742552Platelet-derived growth factor D-like isoform X1. (370 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12 isoform X1. (305 aa)
ZNF408Zinc finger protein 408. (716 aa)
LOC102739066GTP-binding protein Rheb-like. (142 aa)
DGKBDiacylglycerol kinase. (803 aa)
PLA2G4DPhospholipase A2. (817 aa)
PTGFRProstaglandin F2-alpha receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
PPAP2ALipid phosphate phosphohydrolase 1 isoform X1. (286 aa)
LPAR1Lysophosphatidic acid receptor 1 isoform X1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
PIP5K1BPhosphatidylinositol 4-phosphate 5-kinase type-1 beta. (154 aa)
SHC1SHC-transforming protein 1 isoform X2. (583 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (724 aa)
F2RProteinase-activated receptor 1; Belongs to the G-protein coupled receptor 1 family. (427 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
GRM1Metabotropic glutamate receptor 1. (887 aa)
RALARas-related protein Ral-A. (206 aa)
JMJD7jmjC domain-containing protein 7. (316 aa)
SHC4SHC-transforming protein 4. (630 aa)
CEP152Centrosomal protein of 152 kDa isoform X1. (1723 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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