STRINGSTRING
ABL1 ABL1 ZBTB10 ZBTB10 E2F5 E2F5 LOC102746125 LOC102746125 LOC102725945 LOC102725945 LOC102746922 LOC102746922 CCNH CCNH STAG1 STAG1 CDK3 CDK3 WEE1 WEE1 CDK2 CDK2 CDC7 CDC7 CCND3 CCND3 DBF4 DBF4 CCNE2 CCNE2 RBX1 RBX1 SMC1A SMC1A EP300 EP300 PTTG1 PTTG1 PLK1 PLK1 SKP1 SKP1 LOC102745128 LOC102745128 CDKN2C CDKN2C CDC20B CDC20B LOC102737670 LOC102737670 CDC14A CDC14A CDKN1B CDKN1B LOC102733461 LOC102733461 CDK20 CDK20 RBL1 RBL1 MCM4 MCM4 HDAC1 HDAC1 RAD21 RAD21 SMAD4 SMAD4 CDC26 CDC26 YWHAB YWHAB GADD45A GADD45A PCNA PCNA SMC3 SMC3 ANAPC13 ANAPC13 ANAPC5 ANAPC5 ANAPC4 ANAPC4 CDC23 CDC23 CDC25C CDC25C ANAPC2 ANAPC2 LOC102734969 LOC102734969 E2F2 E2F2 TGFB2 TGFB2 ORC5 ORC5 TFDP1 TFDP1 FZR1 FZR1 LOC102730764 LOC102730764 CCNB1 CCNB1 TP53 TP53 CDC14B CDC14B CCNE1 CCNE1 SFN SFN CDC20 CDC20 CDK4 CDK4 MDM2 MDM2 RB1 RB1 CCNB2 CCNB2 CDKN2D CDKN2D CHEK2 CHEK2 E2F4 E2F4 ESPL1 ESPL1 GSK3B GSK3B STAG2 STAG2 CDC25B CDC25B ANAPC11 ANAPC11 HDAC2 HDAC2 LOC102750756 LOC102750756 ATM ATM MYNN MYNN ANAPC10 ANAPC10 WEE2 WEE2 CCND1 CCND1 MCM5 MCM5 CDKN2B CDKN2B CDKN2A CDKN2A LOC102742022 LOC102742022 RAD21L1 RAD21L1 TMEM82 TMEM82 CDC6 CDC6 ZNF652 ZNF652 CREBBP CREBBP GADD45G GADD45G E2F3 E2F3 TGFB1 TGFB1 YWHAH YWHAH TGFB3 TGFB3 ZBTB46 ZBTB46 SNAPIN SNAPIN ZBTB47 ZBTB47 LOC102730711 LOC102730711 LOC102748019 LOC102748019 LOC102739655 LOC102739655 BUB1B BUB1B CDC16 CDC16 GADD45B GADD45B LOC102730318 LOC102730318 LOC102744498 LOC102744498 ORC6 ORC6 CDKN1A CDKN1A ANAPC7 ANAPC7 AP5S1 AP5S1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABL1Tyrosine-protein kinase ABL1-like. (312 aa)
ZBTB10Zinc finger and BTB domain-containing protein 10 isoform X1. (867 aa)
E2F5Transcription factor E2F5 isoform X1. (185 aa)
LOC102746125LOW QUALITY PROTEIN: cyclin-A1-like; Belongs to the cyclin family. (463 aa)
LOC102725945Cyclin-dependent kinase 1-like isoform X1; Belongs to the protein kinase superfamily. (297 aa)
LOC102746922Mitotic checkpoint protein BUB3-like. (142 aa)
CCNHcyclin-H-like; Belongs to the cyclin family. (344 aa)
STAG1Cohesin subunit SA-1 isoform X1. (1258 aa)
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
WEE1Wee1-like protein kinase. (646 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
CDC7Cell division cycle 7-related protein kinase isoform X1. (575 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (291 aa)
DBF4Protein DBF4 homolog A isoform X1. (676 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (344 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X3. (108 aa)
SMC1AStructural maintenance of chromosomes protein. (1233 aa)
EP300Histone acetyltransferase p300. (2425 aa)
PTTG1Securin isoform X1. (201 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
SKP1S-phase kinase-associated protein 1 isoform X1; Belongs to the SKP1 family. (163 aa)
LOC102745128Transcription factor Dp-2-like. (270 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
CDC20BCell division cycle protein 20 homolog B. (454 aa)
LOC102737670Cyclin-dependent kinase 6-like. (322 aa)
CDC14ADual specificity protein phosphatase CDC14A isoform X1. (624 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
LOC102733461F-box/WD repeat-containing protein 12-like. (474 aa)
CDK20Cyclin-dependent kinase 20 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
RBL1Retinoblastoma-like protein 1. (1068 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
RAD21Double-strand-break repair protein rad21 homolog. (631 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CDC26Anaphase-promoting complex subunit CDC26. (85 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (244 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
SMC3Structural maintenance of chromosomes protein. (1217 aa)
ANAPC13Anaphase-promoting complex subunit 13. (74 aa)
ANAPC5Anaphase-promoting complex subunit 5 isoform X1. (755 aa)
ANAPC4Anaphase-promoting complex subunit 4-like. (280 aa)
CDC23Cell division cycle protein 23 homolog. (597 aa)
CDC25CM-phase inducer phosphatase 3 isoform X1. (473 aa)
ANAPC2Anaphase-promoting complex subunit 2; Belongs to the cullin family. (818 aa)
LOC102734969Transcription factor Dp-2-like isoform X1. (160 aa)
E2F2Transcription factor E2F2. (440 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ORC5Origin recognition complex subunit 5. (435 aa)
TFDP1Transcription factor. (290 aa)
FZR1Fizzy-related protein homolog isoform X1. (496 aa)
LOC102730764Mothers against decapentaplegic homolog 2-like. (227 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (427 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
CDC14BDual specificity protein phosphatase CDC14B isoform X1. (498 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
CDC20Cell division cycle protein 20 homolog. (499 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
RB1Retinoblastoma-associated protein. (846 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (299 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D isoform X2. (166 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X1. (544 aa)
E2F4Transcription factor E2F4. (399 aa)
ESPL1Separin. (2105 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
STAG2Cohesin subunit SA-2-like isoform X1. (1268 aa)
CDC25BM-phase inducer phosphatase 2 isoform X1. (516 aa)
ANAPC11Anaphase-promoting complex subunit 11 isoform X1. (84 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
LOC10275075614-3-3 protein epsilon-like; Belongs to the 14-3-3 family. (233 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
MYNNMyoneurin isoform X1. (610 aa)
ANAPC10Anaphase-promoting complex subunit 10; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. (185 aa)
WEE2Wee1-like protein kinase. (566 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoforms 1/2/3. (152 aa)
LOC10274202214-3-3 protein zeta/delta-like isoform X1; Belongs to the 14-3-3 family. (245 aa)
RAD21L1Double-strand-break repair protein rad21-like protein 1 isoform X1. (278 aa)
TMEM82Transmembrane protein 82-like. (344 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
ZNF652Zinc finger protein 652. (457 aa)
CREBBPCREB-binding protein-like. (1411 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
E2F3Transcription factor E2F3-like isoform X1. (465 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (246 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ZBTB46Zinc finger and BTB domain-containing protein 46. (318 aa)
SNAPINSNARE-associated protein Snapin. (137 aa)
ZBTB47Zinc finger protein 652. (748 aa)
LOC102730711DNA replication licensing factor MCM2-like. (149 aa)
LOC102748019DNA replication licensing factor MCM3-like; Belongs to the MCM family. (605 aa)
LOC102739655DNA replication licensing factor MCM3-like. (177 aa)
BUB1BMitotic checkpoint serine/threonine-protein kinase BUB1 beta. (986 aa)
CDC16Cell division cycle protein 16 homolog isoform X1. (620 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta isoform X2. (160 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
LOC10274449814-3-3 protein theta-like; Belongs to the 14-3-3 family. (98 aa)
ORC6Origin recognition complex subunit 6. (252 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
ANAPC7Anaphase-promoting complex subunit 7. (461 aa)
AP5S1AP-5 complex subunit sigma-1 isoform X1. (200 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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