STRINGSTRING
LOC102749461 LOC102749461 RRM2 RRM2 BCL2L1 BCL2L1 CDK3 CDK3 CDK2 CDK2 CCND3 CCND3 SESN1 SESN1 CCNE2 CCNE2 APAF1 APAF1 DDB2 DDB2 RFWD2 RFWD2 IGF1 IGF1 EI24 EI24 PMAIP1 PMAIP1 MDM4 MDM4 RPRM RPRM LOC102737670 LOC102737670 PTEN PTEN LOC102725978 LOC102725978 SERPINE1 SERPINE1 GADD45A GADD45A PPM1D PPM1D LOC102750923 LOC102750923 FAM76B FAM76B CCNG1 CCNG1 CDK4 CDK4 SESN2 SESN2 SFN SFN LOC102730047 LOC102730047 CCNE1 CCNE1 TP53 TP53 CCNB1 CCNB1 CRYZ CRYZ GTSE1 GTSE1 LOC102729504 LOC102729504 SIAH2 SIAH2 CDKN1A CDKN1A STEAP3 STEAP3 LOC102734473 LOC102734473 LOC102734861 LOC102734861 GADD45B GADD45B LOC102746055 LOC102746055 CASP8 CASP8 CASP9 CASP9 LOC102726062 LOC102726062 LOC102738536 LOC102738536 TP73 TP73 GADD45G GADD45G HPS5 HPS5 ZMAT3 ZMAT3 LOC102740819 LOC102740819 LOC102725545 LOC102725545 SERPINB5 SERPINB5 SESN3 SESN3 CASP3 CASP3 CCND1 CCND1 TP53I3 TP53I3 ATM ATM CCNG2 CCNG2 LOC102745799 LOC102745799 THBS1 THBS1 PIDD PIDD CHEK2 CHEK2 CCNB2 CCNB2 RCHY1 RCHY1 MDM2 MDM2 SIVA1 SIVA1 LOC102725945 LOC102725945
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102749461Ribonucleoside-diphosphate reductase subunit M2 B-like isoform X1. (351 aa)
RRM2Ribonucleoside-diphosphate reductase subunit M2. (392 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (291 aa)
SESN1Sestrin-1 isoform X1. (551 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (344 aa)
APAF1Apoptotic protease-activating factor 1. (511 aa)
DDB2DNA damage-binding protein 2 isoform X1. (426 aa)
RFWD2E3 ubiquitin-protein ligase RFWD2-like isoform X1. (570 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
EI24Etoposide-induced protein 2.4 homolog isoform X1. (340 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (492 aa)
RPRMProtein reprimo. (109 aa)
LOC102737670Cyclin-dependent kinase 6-like. (322 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LOC102725978Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (109 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
PPM1DProtein phosphatase 1D. (605 aa)
LOC102750923Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
FAM76BProtein FAM76B. (339 aa)
CCNG1cyclin-G1; Belongs to the cyclin family. (295 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
SESN2Sestrin-2. (481 aa)
SFN14-3-3 protein sigma; Belongs to the 14-3-3 family. (248 aa)
LOC102730047Tuberin-like. (353 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (427 aa)
CRYZQuinone oxidoreductase. (330 aa)
GTSE1G2 and S phase-expressed protein 1. (709 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (198 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
STEAP3Metalloreductase STEAP3-like. (407 aa)
LOC102734473E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (281 aa)
LOC102734861BH3-interacting domain death agonist-like. (83 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta isoform X2. (160 aa)
LOC102746055E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (332 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
CASP9Caspase-9. (171 aa)
LOC102726062Uncharacterized protein C7orf31 homolog. (590 aa)
LOC102738536Insulin-like growth factor-binding protein 3-like. (120 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
HPS5Hermansky-Pudlak syndrome 5 protein. (797 aa)
ZMAT3Zinc finger matrin-type protein 3 isoform X1. (289 aa)
LOC102740819Apoptosis-inducing factor 2-like. (135 aa)
LOC102725545Caspase-9-like; Belongs to the peptidase C14A family. (275 aa)
SERPINB5Serpin B5; Belongs to the serpin family. (242 aa)
SESN3Sestrin-3 isoform X1. (492 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
TP53I3Quinone oxidoreductase PIG3. (332 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
CCNG2cyclin-G2 isoform X1; Belongs to the cyclin family. (343 aa)
LOC102745799Protein FAM76A-like. (171 aa)
THBS1Thrombospondin-1 isoform X1. (1170 aa)
PIDDP53-induced protein with a death domain. (916 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X1. (544 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (299 aa)
RCHY1RING finger and CHY zinc finger domain-containing protein 1 isoform X1. (261 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
SIVA1Apoptosis regulatory protein Siva; Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl- x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis. (175 aa)
LOC102725945Cyclin-dependent kinase 1-like isoform X1; Belongs to the protein kinase superfamily. (297 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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