STRINGSTRING
LMNA LMNA CASP6 CASP6 CTSO CTSO REM1 REM1 BCL2L1 BCL2L1 KRAS KRAS LOC102726446 LOC102726446 CTSS CTSS MCL1 MCL1 NRAS NRAS CSDE1 CSDE1 PIK3R3 PIK3R3 CTSB CTSB MAPK10 MAPK10 MAP2K1 MAP2K1 GEM GEM ATF4 ATF4 APAF1 APAF1 PARP2 PARP2 ERN2 ERN2 PMAIP1 PMAIP1 PARP3 PARP3 RRAD RRAD NFKBIA NFKBIA NFKB1 NFKB1 LOC102725978 LOC102725978 LOC102740084 LOC102740084 TNFSF10 TNFSF10 HTRA1 HTRA1 LOC102732471 LOC102732471 ACTB ACTB TUBAL3 TUBAL3 LOC102745146 LOC102745146 LOC102745453 LOC102745453 SEPT4 SEPT4 LOC102734059 LOC102734059 LOC102738778 LOC102738778 HTRA2 HTRA2 GADD45A GADD45A MAP3K14 MAP3K14 LMNB1 LMNB1 LOC102750923 LOC102750923 LOC102732879 LOC102732879 LOC102728321 LOC102728321 FADD FADD CAPN1 CAPN1 FASLG FASLG SUCO SUCO TNFRSF1A TNFRSF1A ITPR2 ITPR2 BAK1 BAK1 MAPK8 MAPK8 AKT1 AKT1 ERAS ERAS TNF TNF LOC102727326 LOC102727326 MAP2K2 MAP2K2 TP53 TP53 NGF NGF IKBKG IKBKG CAPN12 CAPN12 JUN JUN BCL2A1 BCL2A1 AKT3 AKT3 RAF1 RAF1 LOC102739819 LOC102739819 EIF2AK3 EIF2AK3 CHUK CHUK TRADD TRADD IFITM3 IFITM3 PIDD PIDD ITPR1 ITPR1 TUBA8 TUBA8 CSF2RB CSF2RB XIAP XIAP CTSZ CTSZ TUBA4A TUBA4A LOC102731290 LOC102731290 LOC102746004 LOC102746004 MAPK1 MAPK1 ITPR3 ITPR3 IKBKB IKBKB ATM ATM PARP1 PARP1 LOC102729978 LOC102729978 LOC102739419 LOC102739419 CASP7 CASP7 CASP3 CASP3 PIK3CD PIK3CD LOC102725545 LOC102725545 IL3RA IL3RA FOS FOS PIK3CA PIK3CA CTSH CTSH HPS5 HPS5 GADD45G GADD45G LOC102736516 LOC102736516 PRF1 PRF1 BIRC3 BIRC3 CASP2 CASP2 ACTL8 ACTL8 LOC102738241 LOC102738241 DFFB DFFB NTRK1 NTRK1 LOC102726062 LOC102726062 CASP9 CASP9 LOC102743045 LOC102743045 SPTAN1 SPTAN1 ENDOG ENDOG CASP8 CASP8 LOC102745423 LOC102745423 GADD45B GADD45B BIRC2 BIRC2 LOC102729504 LOC102729504 CAPN9 CAPN9 LOC102741160 LOC102741160 DDIT3 DDIT3 DFFA DFFA IL3 IL3 CTSD CTSD LOC102735556 LOC102735556 LOC102731352 LOC102731352 LOC102738176 LOC102738176 LOC102736146 LOC102736146 BIRC5 BIRC5 LOC102746860 LOC102746860 LOC102751021 LOC102751021 LOC102734861 LOC102734861 CAPN8 CAPN8 ACTG1 ACTG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LMNAprelamin-A/C isoform X1; Belongs to the intermediate filament family. (666 aa)
CASP6Caspase-6 isoform X1; Belongs to the peptidase C14A family. (293 aa)
CTSOCathepsin O; Belongs to the peptidase C1 family. (321 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
KRASGTPase KRas isoform X2. (188 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
CTSSCathepsin S isoform X1; Belongs to the peptidase C1 family. (340 aa)
MCL1Induced myeloid leukemia cell differentiation protein Mcl-1 homolog isoform X1. (350 aa)
NRASGTPase NRas. (189 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CTSBCathepsin B; Belongs to the peptidase C1 family. (339 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
APAF1Apoptotic protease-activating factor 1. (511 aa)
PARP2Poly [ADP-ribose] polymerase. (567 aa)
ERN2Serine/threonine-protein kinase/endoribonuclease IRE2. (926 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
PARP3Poly [ADP-ribose] polymerase. (532 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
LOC102725978Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (109 aa)
LOC102740084Caspase-14-like; Belongs to the peptidase C14A family. (369 aa)
TNFSF10Tumor necrosis factor ligand superfamily member 10; Belongs to the tumor necrosis factor family. (245 aa)
HTRA1Serine protease HTRA1. (167 aa)
LOC102732471Tubulin alpha-1B chain-like. (134 aa)
ACTBActin, cytoplasmic 1. (375 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (398 aa)
LOC102745146Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (173 aa)
LOC102745453SUN domain-containing ossification factor-like. (283 aa)
SEPT4Septin-4 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (476 aa)
LOC102734059Apoptosis-inducing factor 1, mitochondrial-like. (145 aa)
LOC102738778Apoptosis-inducing factor 1, mitochondrial-like. (210 aa)
HTRA2Serine protease HTRA2, mitochondrial isoform X1. (458 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
LMNB1lamin-B1; Belongs to the intermediate filament family. (547 aa)
LOC102750923Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC102732879Disabled homolog 2-interacting protein-like. (454 aa)
LOC102728321High affinity nerve growth factor receptor-like. (109 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
CAPN1Calpain-1 catalytic subunit; Belongs to the peptidase C2 family. (715 aa)
FASLGTumor necrosis factor ligand superfamily member 6. (130 aa)
SUCOSUN domain-containing ossification factor. (983 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
BAK1Bcl-2 homologous antagonist/killer. (211 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
ERASGTPase ERas. (233 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
LOC102727326Cathepsin L1-like isoform X1; Belongs to the peptidase C1 family. (334 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
CAPN12Calpain-12; Belongs to the peptidase C2 family. (681 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
BCL2A1Bcl-2-related protein A1. (174 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
LOC102739819Spectrin alpha chain, erythrocytic 1-like. (1472 aa)
EIF2AK3Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1. (1114 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (312 aa)
IFITM3Interferon-induced transmembrane protein 3. (146 aa)
PIDDP53-induced protein with a death domain. (916 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
TUBA8Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
CSF2RBCytokine receptor common subunit beta. (902 aa)
XIAPE3 ubiquitin-protein ligase XIAP-like isoform X1. (497 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (302 aa)
TUBA4ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
LOC102731290Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
LOC102746004Bcl-2-like protein 11-like isoform X2. (140 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
PARP1Poly [ADP-ribose] polymerase. (686 aa)
LOC102729978Beta-actin-like protein 2-like isoform X1. (376 aa)
LOC102739419Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
CASP7Caspase-7; Belongs to the peptidase C14A family. (301 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (302 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
LOC102725545Caspase-9-like; Belongs to the peptidase C14A family. (275 aa)
IL3RAInterleukin-3 receptor subunit alpha. (376 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CTSHPro-cathepsin H; Belongs to the peptidase C1 family. (331 aa)
HPS5Hermansky-Pudlak syndrome 5 protein. (797 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
PRF1Perforin-1. (555 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
CASP2Caspase-2; Belongs to the peptidase C14A family. (312 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (366 aa)
LOC102738241Mitogen-activated protein kinase kinase kinase 5-like. (795 aa)
DFFBDNAation factor subunit beta. (341 aa)
NTRK1Tyrosine-protein kinase receptor. (592 aa)
LOC102726062Uncharacterized protein C7orf31 homolog. (590 aa)
CASP9Caspase-9. (171 aa)
LOC102743045Disabled homolog 2-interacting protein-like. (326 aa)
SPTAN1Spectrin alpha chain, non-erythrocytic 1. (1138 aa)
ENDOGEndonuclease. (342 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
LOC102745423Spectrin alpha chain, non-erythrocytic 1-like. (816 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta isoform X2. (160 aa)
BIRC2Baculoviral IAP repeat-containing protein 2-like. (619 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
CAPN9Calpain-9; Belongs to the peptidase C2 family. (492 aa)
LOC102741160LOW QUALITY PROTEIN: uncharacterized protein C17orf47 homolog. (571 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
DFFADNAation factor subunit alpha. (327 aa)
IL3Interleukin-3. (143 aa)
CTSDCathepsin D; Belongs to the peptidase A1 family. (410 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
LOC102731352Serine/threonine-protein kinase/endoribonuclease IRE1-like. (414 aa)
LOC102738176Spectrin alpha chain, erythrocytic 1-like. (1276 aa)
LOC1027361463-phosphoinositide-dependent protein kinase 1-like. (216 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (74 aa)
LOC102746860Apoptosis-inducing factor 1, mitochondrial-like. (232 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102734861BH3-interacting domain death agonist-like. (83 aa)
CAPN8LOW QUALITY PROTEIN: calpain 8; Belongs to the peptidase C2 family. (566 aa)
ACTG1LOW QUALITY PROTEIN: actin, gamma 1. (411 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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