STRINGSTRING
LOC102731038 LOC102731038 LOC102751021 LOC102751021 PRKAG1 PRKAG1 CSDE1 CSDE1 PIK3R3 PIK3R3 RHEBL1 RHEBL1 ADCY6 ADCY6 SESN1 SESN1 FOXO3 FOXO3 ATF4 ATF4 LOC102739066 LOC102739066 IGF1 IGF1 NFKB1 NFKB1 EIF4E1B EIF4E1B SOD2 SOD2 PRKAA1 PRKAA1 CREB1 CREB1 RB1CC1 RB1CC1 MTOR MTOR IRS1 IRS1 PRKACB PRKACB CAMKK2 CAMKK2 IGF1R IGF1R AKT1 AKT1 ERAS ERAS EHMT2 EHMT2 ATF6B ATF6B CREB3L3 CREB3L3 TP53 TP53 LOC102730047 LOC102730047 ATG5 ATG5 PRKAB1 PRKAB1 LOC102749673 LOC102749673 SESN2 SESN2 AKT3 AKT3 KRAS KRAS LOC102726446 LOC102726446 NRAS NRAS RPS6KB1 RPS6KB1 PTRHD1 PTRHD1 ATF2 ATF2 PRKAG2 PRKAG2 LOC102748583 LOC102748583 ADIPOR1 ADIPOR1 ADCY9 ADCY9 LOC102726827 LOC102726827 SESN3 SESN3 LOC102746012 LOC102746012 PIK3CD PIK3CD PIK3CA PIK3CA PPARGC1A PPARGC1A LOC102736516 LOC102736516 CREB3L1 CREB3L1 LOC102743783 LOC102743783 LOC102731850 LOC102731850 EIF4E2 EIF4E2 CAMK4 CAMK4 INS INS LOC102729504 LOC102729504 FOXO1 FOXO1 AKT1S1 AKT1S1 RPS6KB2 RPS6KB2 PRKACA PRKACA LOC102735948 LOC102735948 LOC102743057 LOC102743057 LOC102727190 LOC102727190
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
PRKAG15'-AMP-activated protein kinase subunit gamma-1 isoform X1. (298 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
RHEBL1GTPase RhebL1. (183 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
SESN1Sestrin-1 isoform X1. (551 aa)
FOXO3Forkhead box protein O3. (672 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
LOC102739066GTP-binding protein Rheb-like. (142 aa)
IGF1Insulin-like growth factor I isoform X1. (153 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
EIF4E1BEukaryotic translation initiation factor 4E type 1B; Belongs to the eukaryotic initiation factor 4E family. (215 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
RB1CC1RB1-inducible coiled-coil protein 1 isoform X1. (1593 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
IRS1Insulin receptor substrate 1-like isoform X1. (1236 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
CAMKK2Calcium/calmodulin-dependent protein kinase kinase 2 isoform X1. (578 aa)
IGF1RInsulin-like growth factor 1 receptor-like. (291 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
ERASGTPase ERas. (233 aa)
EHMT2Histone-lysine N-methyltransferase EHMT2 isoform X1. (1268 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (623 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (466 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
LOC102730047Tuberin-like. (353 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (255 aa)
PRKAB15'-AMP-activated protein kinase subunit beta-1. (270 aa)
LOC102749673Insulin-like growth factor 1 receptor-like. (143 aa)
SESN2Sestrin-2. (481 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
KRASGTPase KRas isoform X2. (188 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
NRASGTPase NRas. (189 aa)
RPS6KB1Non-specific serine/threonine protein kinase. (445 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X2. (505 aa)
PRKAG25'-AMP-activated protein kinase subunit gamma-2-like isoform X2. (327 aa)
LOC1027485835'-AMP-activated protein kinase subunit gamma-2-like. (129 aa)
ADIPOR1Adiponectin receptor protein 1. (375 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
LOC102726827Eukaryotic translation initiation factor 4E-like; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
SESN3Sestrin-3 isoform X1. (492 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha-like isoform X2. (671 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
LOC102743783Histone-lysine N-methyltransferase EHMT1-like. (467 aa)
LOC102731850Tyrosine-protein kinase receptor. (757 aa)
EIF4E2Eukaryotic translation initiation factor 4E type 2; Belongs to the eukaryotic initiation factor 4E family. (192 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV. (360 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
FOXO1Forkhead box protein O1-like. (418 aa)
AKT1S1Proline-rich AKT1 substrate 1. (276 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LOC102735948Autophagy-related protein 13-like. (287 aa)
LOC102743057Autophagy-related protein 101. (218 aa)
LOC102727190Serine/threonine-protein kinase STK11-like. (545 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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