(31 nodes) Apoptosis - multiple species network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BAK1	Bcl-2 homologous antagonist/killer. (211 aa)
	BIRC7	Baculoviral IAP repeat-containing protein 7. (287 aa)
	TNFRSF1A	Tumor necrosis factor receptor superfamily member 1A. (358 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
	LOC102750923	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	HTRA2	Serine protease HTRA2, mitochondrial isoform X1. (458 aa)
	SEPT4	Septin-4 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (476 aa)
	LOC102725978	Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (109 aa)
	PMAIP1	Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
	APAF1	Apoptotic protease-activating factor 1. (511 aa)
	MAPK10	Mitogen-activated protein kinase. (464 aa)
	LOC102744579	Transmembrane protein 198-like. (350 aa)
	BCL2L1	Bcl-2-like protein 1 isoform X1. (233 aa)
	LOC102734861	BH3-interacting domain death agonist-like. (83 aa)
	BIRC5	Baculoviral IAP repeat-containing protein 5. (74 aa)
	LOC102735556	Mitogen-activated protein kinase 9-like. (134 aa)
	BOK	Bcl-2-related ovarian killer protein. (213 aa)
	LOC102741160	LOW QUALITY PROTEIN: uncharacterized protein C17orf47 homolog. (571 aa)
	LOC102729504	Apoptosis regulator BAX-like. (212 aa)
	TMEM198	Transmembrane protein 198. (360 aa)
	BIRC2	Baculoviral IAP repeat-containing protein 2-like. (619 aa)
	CASP8	Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
	CASP9	Caspase-9. (171 aa)
	LOC102726062	Uncharacterized protein C7orf31 homolog. (590 aa)
	BIRC3	Baculoviral IAP repeat-containing protein 3. (604 aa)
	LOC102725545	Caspase-9-like; Belongs to the peptidase C14A family. (275 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (302 aa)
	CASP7	Caspase-7; Belongs to the peptidase C14A family. (301 aa)
	LOC102746004	Bcl-2-like protein 11-like isoform X2. (140 aa)
	XIAP	E3 ubiquitin-protein ligase XIAP-like isoform X1. (497 aa)
	MAPK8	Mitogen-activated protein kinase. (427 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BAK1	A0A2U3XFH1	A0A2U3Y360	Apoptotic protease-activating factor 1.	Bcl-2 homologous antagonist/killer.	0.775
APAF1	BCL2L1	A0A2U3XFH1	A0A2U3X803	Apoptotic protease-activating factor 1.	Bcl-2-like protein 1 isoform X1.	0.775
APAF1	BIRC2	A0A2U3XFH1	A0A2U3Z1X8	Apoptotic protease-activating factor 1.	Baculoviral IAP repeat-containing protein 2-like.	0.752
APAF1	BIRC3	A0A2U3XFH1	A0A2U3YVF5	Apoptotic protease-activating factor 1.	Baculoviral IAP repeat-containing protein 3.	0.752
APAF1	BIRC5	A0A2U3XFH1	A0A2U3Z724	Apoptotic protease-activating factor 1.	Baculoviral IAP repeat-containing protein 5.	0.752
APAF1	BIRC7	A0A2U3XFH1	A0A2U3Y2P0	Apoptotic protease-activating factor 1.	Baculoviral IAP repeat-containing protein 7.	0.752
APAF1	BOK	A0A2U3XFH1	A0A2U3Z482	Apoptotic protease-activating factor 1.	Bcl-2-related ovarian killer protein.	0.720
APAF1	CASP3	A0A2U3XFH1	A0A2U3YM46	Apoptotic protease-activating factor 1.	Caspase-3; Belongs to the peptidase C14A family.	0.993
APAF1	CASP7	A0A2U3XFH1	A0A2U3YLS0	Apoptotic protease-activating factor 1.	Caspase-7; Belongs to the peptidase C14A family.	0.949
APAF1	CASP8	A0A2U3XFH1	A0A2U3Z0R6	Apoptotic protease-activating factor 1.	Caspase-8 isoform X1; Belongs to the peptidase C14A family.	0.970
APAF1	CASP9	A0A2U3XFH1	A0A2U3YZ30	Apoptotic protease-activating factor 1.	Caspase-9.	0.995
APAF1	FADD	A0A2U3XFH1	A0A2U3XZM0	Apoptotic protease-activating factor 1.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.508
APAF1	HTRA2	A0A2U3XFH1	A0A2U3XVA2	Apoptotic protease-activating factor 1.	Serine protease HTRA2, mitochondrial isoform X1.	0.556
APAF1	LOC102725545	A0A2U3XFH1	A0A2U3YPV6	Apoptotic protease-activating factor 1.	Caspase-9-like; Belongs to the peptidase C14A family.	0.988
APAF1	LOC102725978	A0A2U3XFH1	A0A2U3XPB7	Apoptotic protease-activating factor 1.	Cytochrome c 2-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.993
APAF1	LOC102729504	A0A2U3XFH1	A0A2U3Z356	Apoptotic protease-activating factor 1.	Apoptosis regulator BAX-like.	0.720
APAF1	LOC102734861	A0A2U3XFH1	A0A2U3Z8M2	Apoptotic protease-activating factor 1.	BH3-interacting domain death agonist-like.	0.487
APAF1	LOC102744579	A0A2U3XFH1	A0A2U3XBM3	Apoptotic protease-activating factor 1.	Transmembrane protein 198-like.	0.899
APAF1	LOC102746004	A0A2U3XFH1	A0A2U3YHX1	Apoptotic protease-activating factor 1.	Bcl-2-like protein 11-like isoform X2.	0.407
APAF1	LOC102750923	A0A2U3XFH1	A0A2U3XXZ4	Apoptotic protease-activating factor 1.	Cytochrome c-like; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999