STRINGSTRING
LOC102731864 LOC102731864 LOC102746860 LOC102746860 LOC102749847 LOC102749847 LOC102735556 LOC102735556 RAB44 RAB44 ARSI ARSI CAMK2A CAMK2A STAT3 STAT3 STAT5A STAT5A CAPN9 CAPN9 LOC102729504 LOC102729504 LOC102743792 LOC102743792 LOC102744100 LOC102744100 BIRC2 BIRC2 VDAC2 VDAC2 LOC102740456 LOC102740456 JAK3 JAK3 CASP8 CASP8 IFNAR1 IFNAR1 LOC102730207 LOC102730207 CHMP1B CHMP1B LOC102726670 LOC102726670 LOC102750685 LOC102750685 LOC102726367 LOC102726367 LOC102728885 LOC102728885 RNF103 RNF103 GLUD1 GLUD1 HSP90AB1 HSP90AB1 CHMP2A CHMP2A BIRC3 BIRC3 USP21 USP21 FTL FTL SMPD1 SMPD1 TYK2 TYK2 PGPEP1 PGPEP1 SHARPIN SHARPIN SPATA2L SPATA2L PGAM5 PGAM5 VPS4B VPS4B PYGB PYGB LOC102740321 LOC102740321 CHMP1A CHMP1A LOC102731297 LOC102731297 IL1A IL1A LOC102729768 LOC102729768 LOC102730373 LOC102730373 IL1B IL1B PARP1 PARP1 LOC102740611 LOC102740611 XKRX XKRX VDAC3 VDAC3 PELP1 PELP1 XIAP XIAP NLRP10 NLRP10 LOC102749969 LOC102749969 EFCAB4A EFCAB4A TRADD TRADD SLC25A5 SLC25A5 LOC102739213 LOC102739213 TRPM7 TRPM7 STAT2 STAT2 CHMP7 CHMP7 IFNG IFNG USP2 USP2 CAPN12 CAPN12 IRF9 IRF9 CHMP4A CHMP4A RNF31 RNF31 LOC102731789 LOC102731789 STAT5B STAT5B LOC102745161 LOC102745161 TNF TNF MAPK8 MAPK8 TNFRSF1A TNFRSF1A LOC102748068 LOC102748068 HMGB2 HMGB2 SUCO SUCO FASLG FASLG EIF2AK2 EIF2AK2 JAK2 JAK2 PYGM PYGM CAPN1 CAPN1 TICAM2 TICAM2 TMED7 TMED7 FADD FADD LOC102746189 LOC102746189 LOC102738582 LOC102738582 JMJD7 JMJD7 IFNGR2 IFNGR2 LOC102732990 LOC102732990 LOC102751118 LOC102751118 LOC102749658 LOC102749658 LOC102747282 LOC102747282 LOC102738778 LOC102738778 LOC102734059 LOC102734059 SLC25A4 SLC25A4 TNFAIP3 TNFAIP3 LOC102745453 LOC102745453 LOC102745146 LOC102745146 CHMP5 CHMP5 LOC102751218 LOC102751218 LOC102750808 LOC102750808 TNFSF10 TNFSF10 CAMK2G CAMK2G IFNB1 IFNB1 LOC102747471 LOC102747471 LOC102750324 LOC102750324 LOC102747757 LOC102747757 LOC102739480 LOC102739480 SPATA2 SPATA2 PLA2G4D PLA2G4D PYGL PYGL VPS4A VPS4A PYCARD PYCARD LOC102741342 LOC102741342 MAPK10 MAPK10 GLUL GLUL DNM1L DNM1L CHMP4C CHMP4C IFNA14 IFNA14 CAPN8 CAPN8 LOC102734861 LOC102734861 LOC102729524 LOC102729524
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102731864Signal transducer and activator of transcription 5B-like. (353 aa)
LOC102746860Apoptosis-inducing factor 1, mitochondrial-like. (232 aa)
LOC102749847Tyrosine-protein kinase JAK1-like. (444 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
RAB44Ras-related protein Rab-44. (795 aa)
ARSIArylsulfatase I. (575 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha. (476 aa)
STAT3Signal transducer and activator of transcription 3-like. (424 aa)
STAT5ASignal transducer and activator of transcription 5A. (464 aa)
CAPN9Calpain-9; Belongs to the peptidase C2 family. (492 aa)
LOC102729504Apoptosis regulator BAX-like. (212 aa)
LOC102743792Histone H2A; Belongs to the histone H2A family. (129 aa)
LOC102744100Histone H2A; Belongs to the histone H2A family. (130 aa)
BIRC2Baculoviral IAP repeat-containing protein 2-like. (619 aa)
VDAC2Voltage-dependent anion-selective channel protein 2 isoform X1. (294 aa)
LOC102740456Uncharacterized protein LOC102740456. (329 aa)
JAK3Tyrosine-protein kinase. (1139 aa)
CASP8Caspase-8 isoform X1; Belongs to the peptidase C14A family. (486 aa)
IFNAR1Interferon alpha/beta receptor 1. (560 aa)
LOC102730207Histone H2A; Belongs to the histone H2A family. (143 aa)
CHMP1BCharged multivesicular body protein 1b. (199 aa)
LOC102726670Histone H2A; Belongs to the histone H2A family. (131 aa)
LOC102750685Histone H2A; Belongs to the histone H2A family. (131 aa)
LOC102726367Heat shock protein HSP 90-alpha-like. (262 aa)
LOC102728885High mobility group protein B3-like isoform X1. (201 aa)
RNF103E3 ubiquitin-protein ligase RNF103 isoform X1. (684 aa)
GLUD1Glutamate dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (391 aa)
HSP90AB1Heat shock protein HSP 90-beta. (464 aa)
CHMP2ACharged multivesicular body protein 2a isoform X1. (222 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
USP21Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (565 aa)
FTLFerritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (175 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
TYK2Non-receptor tyrosine-protein kinase TYK2-like. (767 aa)
PGPEP1Pyroglutamyl-peptidase 1. (209 aa)
SHARPINSharpin isoform X1. (283 aa)
SPATA2LSpermatogenesis-associated protein 2-like protein. (413 aa)
PGAM5Serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1. (289 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (444 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
LOC102740321High mobility group protein B4-like. (194 aa)
CHMP1ACharged multivesicular body protein 1a. (196 aa)
LOC102731297Histone H2A; Belongs to the histone H2A family. (117 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
LOC102729768Huntingtin-interacting protein M. (113 aa)
LOC102730373Cytochrome b-245 heavy chain-like. (550 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
PARP1Poly [ADP-ribose] polymerase. (686 aa)
LOC102740611TNF receptor-associated factor. (490 aa)
XKRXXK-related protein. (449 aa)
VDAC3Voltage-dependent anion-selective channel protein 3 isoform X1. (284 aa)
PELP1Proline-, glutamic acid- and leucine-rich protein 1 isoform X2. (984 aa)
XIAPE3 ubiquitin-protein ligase XIAP-like isoform X1. (497 aa)
NLRP10LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 10. (640 aa)
LOC102749969Interleukin-33-like. (267 aa)
EFCAB4AEF-hand calcium-binding domain-containing protein 4A. (398 aa)
TRADDTumor necrosis factor receptor type 1-associated DEATH domain protein. (312 aa)
SLC25A5ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
LOC102739213High mobility group protein B1-like. (214 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1731 aa)
STAT2Signal transducer and activator of transcription. (854 aa)
CHMP7Charged multivesicular body protein 7 isoform X1. (450 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (606 aa)
CAPN12Calpain-12; Belongs to the peptidase C2 family. (681 aa)
IRF9Interferon regulatory factor 9 isoform X1. (445 aa)
CHMP4ALOW QUALITY PROTEIN: charged multivesicular body protein 4a. (265 aa)
RNF31E3 ubiquitin-protein ligase RNF31 isoform X1. (1080 aa)
LOC102731789Ferritin; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. (183 aa)
STAT5BSignal transducer and activator of transcription 5B. (508 aa)
LOC102745161Signal transducer and activator of transcription 3-like. (301 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
LOC102748068Cytochrome b-245 heavy chain-like. (135 aa)
HMGB2High mobility group protein B2 isoform X1. (210 aa)
SUCOSUN domain-containing ossification factor. (983 aa)
FASLGTumor necrosis factor ligand superfamily member 6. (130 aa)
EIF2AK2Interferon-induced, double-stranded RNA-activated protein kinase. (541 aa)
JAK2Tyrosine-protein kinase. (952 aa)
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (625 aa)
CAPN1Calpain-1 catalytic subunit; Belongs to the peptidase C2 family. (715 aa)
TICAM2TIR domain-containing adapter molecule 2. (238 aa)
TMED7Transmembrane emp24 domain-containing protein 7. (224 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (218 aa)
LOC102746189Histone H2A; Belongs to the histone H2A family. (102 aa)
LOC102738582Histone H2A; Belongs to the histone H2A family. (130 aa)
JMJD7jmjC domain-containing protein 7. (316 aa)
IFNGR2Interferon gamma receptor 2. (115 aa)
LOC102732990Histone H2A; Belongs to the histone H2A family. (140 aa)
LOC102751118Histone H2A; Belongs to the histone H2A family. (128 aa)
LOC102749658Histone H2A; Belongs to the histone H2A family. (140 aa)
LOC102747282Histone H2A; Belongs to the histone H2A family. (130 aa)
LOC102738778Apoptosis-inducing factor 1, mitochondrial-like. (210 aa)
LOC102734059Apoptosis-inducing factor 1, mitochondrial-like. (145 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (790 aa)
LOC102745453SUN domain-containing ossification factor-like. (283 aa)
LOC102745146Tumor necrosis factor ligand superfamily member 6-like; Belongs to the tumor necrosis factor family. (173 aa)
CHMP5Charged multivesicular body protein 5. (232 aa)
LOC102751218Voltage-dependent anion-selective channel protein 1-like. (280 aa)
LOC102750808Histone H2A; Belongs to the histone H2A family. (129 aa)
TNFSF10Tumor necrosis factor ligand superfamily member 10; Belongs to the tumor necrosis factor family. (245 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (574 aa)
IFNB1Interferon beta. (182 aa)
LOC102747471Interferon alpha-1/2-like. (187 aa)
LOC102750324Interferon alpha-2-like. (175 aa)
LOC102747757Interferon alpha-1/2-like. (187 aa)
LOC102739480Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (251 aa)
SPATA2Spermatogenesis-associated protein 2. (520 aa)
PLA2G4DPhospholipase A2. (817 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (851 aa)
VPS4AVacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family. (437 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (194 aa)
LOC102741342Lengsin-like; Belongs to the glutamine synthetase family. (574 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
GLULGlutamine synthetase. (413 aa)
DNM1LDynamin-1-like protein isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa)
CHMP4CCharged multivesicular body protein 4c. (237 aa)
IFNA14LOW QUALITY PROTEIN: interferon, alpha 14. (182 aa)
CAPN8LOW QUALITY PROTEIN: calpain 8; Belongs to the peptidase C2 family. (566 aa)
LOC102734861BH3-interacting domain death agonist-like. (83 aa)
LOC102729524Transient receptor potential cation channel subfamily M member 7-like. (129 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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