STRINGSTRING
LOC102736922 LOC102736922 E2F5 E2F5 LOC102746125 LOC102746125 CCDC109B CCDC109B LOC102725945 LOC102725945 REM1 REM1 PPP3R2 PPP3R2 KRAS KRAS MRAS MRAS LOC102726446 LOC102726446 CDK3 CDK3 RASSF5 RASSF5 NRAS NRAS HIPK1 HIPK1 CSDE1 CSDE1 CDK2 CDK2 PIK3R3 PIK3R3 CCND3 CCND3 RHEBL1 RHEBL1 GATA4 GATA4 FOXO3 FOXO3 MAP2K1 MAP2K1 CCNE2 CCNE2 IL8 IL8 GEM GEM PPP3R1 PPP3R1 NFATC3 NFATC3 LOC102739066 LOC102739066 LIN52 LIN52 RRAD RRAD MAP2K6 MAP2K6 LOC102738071 LOC102738071 HUS1 HUS1 NFKB1 NFKB1 LOC102737670 LOC102737670 PTEN PTEN LOC102739480 LOC102739480 GATA6 GATA6 KIAA1671 KIAA1671 RBL1 RBL1 SERPINE1 SERPINE1 TGFBR2 TGFBR2 RBBP4 RBBP4 LOC102751218 LOC102751218 MYBL2 MYBL2 RAD50 RAD50 SLC25A4 SLC25A4 MAPK12 MAPK12 GADD45A GADD45A TRAF3IP2 TRAF3IP2 MTOR MTOR RAD1 RAD1 HIPK2 HIPK2 RBBP7 RBBP7 PPP1CC PPP1CC CAPN1 CAPN1 E2F2 E2F2 ITPR2 ITPR2 TGFB2 TGFB2 AKT1 AKT1 ERAS ERAS LOC102746195 LOC102746195 LOC102730764 LOC102730764 MAP2K2 MAP2K2 CCNB1 CCNB1 TP53 TP53 CCNE1 CCNE1 LOC102730047 LOC102730047 CAPN12 CAPN12 ZFP36L1 ZFP36L1 AKT3 AKT3 CDK4 CDK4 MDM2 MDM2 HIPK3 HIPK3 RAF1 RAF1 ETS1 ETS1 RB1 RB1 CCNB2 CCNB2 TRPM7 TRPM7 SLC25A5 SLC25A5 CHEK2 CHEK2 E2F4 E2F4 PPP1CB PPP1CB ITPR1 ITPR1 TRPV4 TRPV4 ZFP36L2 ZFP36L2 MTL5 MTL5 IL6 IL6 LIN37 LIN37 HIPK4 HIPK4 MAPK1 MAPK1 ITPR3 ITPR3 VDAC3 VDAC3 LOC102730893 LOC102730893 ATM ATM LIN9 LIN9 RRAS RRAS CCND1 CCND1 IL1A IL1A CALM3 CALM3 LOC102749983 LOC102749983 CDKN2B CDKN2B CDKN2A CDKN2A PIK3CD PIK3CD PIK3CA PIK3CA NFATC1 NFATC1 LOC102725943 LOC102725943 LOC102735909 LOC102735909 MAP2K3 MAP2K3 GADD45G GADD45G LOC102736516 LOC102736516 E2F3 E2F3 TGFB1 TGFB1 TGFB3 TGFB3 TPRG1L TPRG1L LOC102743982 LOC102743982 LOC102738536 LOC102738536 PPP1CA PPP1CA RAD9A RAD9A LOC102743250 LOC102743250 VDAC2 VDAC2 GADD45B GADD45B LOC102730318 LOC102730318 CAPN9 CAPN9 FOXO1 FOXO1 LOC102733263 LOC102733263 CDKN1A CDKN1A FOXM1 FOXM1 LOC102733954 LOC102733954 MAPK11 MAPK11 LOC102741568 LOC102741568 LOC102751021 LOC102751021 LOC102729524 LOC102729524 CAPN8 CAPN8 CALML4 CALML4 EFCAB13 EFCAB13
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102736922Calmodulin-like; Belongs to the calmodulin family. (223 aa)
E2F5Transcription factor E2F5 isoform X1. (185 aa)
LOC102746125LOW QUALITY PROTEIN: cyclin-A1-like; Belongs to the cyclin family. (463 aa)
CCDC109BMitochondrial calcium uniporter regulatory subunit MCUb. (84 aa)
LOC102725945Cyclin-dependent kinase 1-like isoform X1; Belongs to the protein kinase superfamily. (297 aa)
REM1GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
KRASGTPase KRas isoform X2. (188 aa)
MRASRas-related protein M-Ras. (208 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
CDK3Cyclin-dependent kinase 3; Belongs to the protein kinase superfamily. (305 aa)
RASSF5Ras association domain-containing protein 5. (194 aa)
NRASGTPase NRas. (189 aa)
HIPK1Homeodomain-interacting protein kinase 1 isoform X2. (1080 aa)
CSDE1Cold shock domain-containing protein E1 isoform X1. (845 aa)
CDK2Cyclin-dependent kinase 2 isoform X1; Belongs to the protein kinase superfamily. (346 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (291 aa)
RHEBL1GTPase RhebL1. (183 aa)
GATA4Transcription factor GATA-4 isoform X1. (443 aa)
FOXO3Forkhead box protein O3. (672 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (344 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (104 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1075 aa)
LOC102739066GTP-binding protein Rheb-like. (142 aa)
LIN52Protein lin-52 homolog. (108 aa)
RRADGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LOC102738071Calmodulin-like; Belongs to the calmodulin family. (113 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
LOC102737670Cyclin-dependent kinase 6-like. (322 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
LOC102739480Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (251 aa)
GATA6Transcription factor GATA-6. (287 aa)
KIAA1671Uncharacterized protein KIAA1671 homolog. (308 aa)
RBL1Retinoblastoma-like protein 1. (1068 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
RBBP4Histone-binding protein RBBP4. (380 aa)
LOC102751218Voltage-dependent anion-selective channel protein 1-like. (280 aa)
MYBL2Myb-related protein B. (290 aa)
RAD50DNA repair protein RAD50. (973 aa)
SLC25A4ADP/ATP translocase 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
GADD45AGrowth arrest and DNA damage-inducible protein GADD45 alpha isoform X1. (165 aa)
TRAF3IP2Adapter protein CIKS isoform X1. (563 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
RAD1Cell cycle checkpoint protein RAD1. (281 aa)
HIPK2Homeodomain-interacting protein kinase 2-like isoform X1. (1188 aa)
RBBP7Histone-binding protein RBBP7 isoform X1. (469 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
CAPN1Calpain-1 catalytic subunit; Belongs to the peptidase C2 family. (715 aa)
E2F2Transcription factor E2F2. (440 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
ERASGTPase ERas. (233 aa)
LOC102746195DLA class I histocompatibility antigen, A9/A9 alpha chain-like. (189 aa)
LOC102730764Mothers against decapentaplegic homolog 2-like. (227 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
CCNB1G2/mitotic-specific cyclin-B1; Belongs to the cyclin family. (427 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
LOC102730047Tuberin-like. (353 aa)
CAPN12Calpain-12; Belongs to the peptidase C2 family. (681 aa)
ZFP36L1Zinc finger protein 36, C3H1 type-like 1 isoform X1. (338 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
CDK4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (303 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (487 aa)
HIPK3Homeodomain-interacting protein kinase 3 isoform X1. (1215 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
ETS1Protein C-ets-1-like isoform X1. (441 aa)
RB1Retinoblastoma-associated protein. (846 aa)
CCNB2G2/mitotic-specific cyclin-B2; Belongs to the cyclin family. (299 aa)
TRPM7Transient receptor potential cation channel subfamily M member 7. (1731 aa)
SLC25A5ADP/ATP translocase 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X1. (544 aa)
E2F4Transcription factor E2F4. (399 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (742 aa)
ZFP36L2Zinc finger protein 36, C3H1 type-like 2-like. (491 aa)
MTL5Tesmin. (511 aa)
IL6Interleukin-6 isoform X1. (212 aa)
LIN37Protein lin-37 homolog. (246 aa)
HIPK4Homeodomain-interacting protein kinase 4. (615 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
VDAC3Voltage-dependent anion-selective channel protein 3 isoform X1. (284 aa)
LOC102730893Tumor protein p63-regulated gene 1 protein-like. (279 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3054 aa)
LIN9Protein lin-9 homolog isoform X1. (490 aa)
RRASRas-related protein R-Ras. (218 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
CALM3Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
LOC102749983F-box/WD repeat-containing protein 11-like. (264 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoforms 1/2/3. (152 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
LOC102725943Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
LOC102735909Class I histocompatibility antigen, Gogo-C*0203 alpha chain-like; Belongs to the MHC class I family. (309 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
GADD45GGrowth arrest and DNA damage-inducible protein GADD45 gamma. (159 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
E2F3Transcription factor E2F3-like isoform X1. (465 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TPRG1LTumor protein p63-regulated gene 1-like protein. (209 aa)
LOC102743982LOW QUALITY PROTEIN: zinc-alpha-2-glycoprotein-like; Belongs to the MHC class I family. (313 aa)
LOC102738536Insulin-like growth factor-binding protein 3-like. (120 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (391 aa)
LOC102743250Transcription factor GATA-5-like. (300 aa)
VDAC2Voltage-dependent anion-selective channel protein 2 isoform X1. (294 aa)
GADD45BGrowth arrest and DNA damage-inducible protein GADD45 beta isoform X2. (160 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
CAPN9Calpain-9; Belongs to the peptidase C2 family. (492 aa)
FOXO1Forkhead box protein O1-like. (418 aa)
LOC102733263Double-strand break repair protein MRE11A-like. (83 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (161 aa)
FOXM1Forkhead box protein M1 isoform X5. (692 aa)
LOC102733954Calmodulin-like protein 4-like. (119 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102741568Protein lin-54 homolog. (352 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102729524Transient receptor potential cation channel subfamily M member 7-like. (129 aa)
CAPN8LOW QUALITY PROTEIN: calpain 8; Belongs to the peptidase C2 family. (566 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like 4. (199 aa)
EFCAB13LOW QUALITY PROTEIN: EF-hand calcium binding domain 13. (905 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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