STRINGSTRING
TPM2 TPM2 TNNT3 TNNT3 ATP1A1 ATP1A1 LOC102735730 LOC102735730 PPP2R3B PPP2R3B PPP1CA PPP1CA LOC102726374 LOC102726374 LOC102730715 LOC102730715 LOC102730623 LOC102730623 LOC102740654 LOC102740654 AGT AGT LOC102730629 LOC102730629 SLC39A12 SLC39A12 CAMK2A CAMK2A ARSI ARSI TPM4 TPM4 PRKACA PRKACA LOC102733954 LOC102733954 LOC102731038 LOC102731038 MAPK11 MAPK11 LOC102730020 LOC102730020 LOC102749357 LOC102749357 LOC102749446 LOC102749446 LOC102726696 LOC102726696 LOC102740174 LOC102740174 CALML4 CALML4 LOC102735756 LOC102735756 EFCAB13 EFCAB13 PPP1R1C PPP1R1C LOC102736922 LOC102736922 CACNA2D1 CACNA2D1 PPP2R3A PPP2R3A SLC8A1 SLC8A1 AGTR2 AGTR2 ATF7 ATF7 PPP1R1A PPP1R1A CACNB3 CACNB3 ADCY6 ADCY6 CACNG5 CACNG5 CACNG1 CACNG1 CACNG4 CACNG4 ATF4 ATF4 SCN1B SCN1B PPP2CB PPP2CB TNNC1 TNNC1 ATP1A3 ATP1A3 LOC102738071 LOC102738071 LOC102726697 LOC102726697 CREB1 CREB1 LOC102741278 LOC102741278 CAMK2G CAMK2G SLC8A3 SLC8A3 MAPK12 MAPK12 CREM CREM KCNQ1 KCNQ1 CACNB2 CACNB2 PPP2R5D PPP2R5D PPP2R2A PPP2R2A ADRA1A ADRA1A PRKACB PRKACB PPP1CC PPP1CC MYL2 MYL2 CACNG7 CACNG7 CACNG6 CACNG6 MYL3 MYL3 GNAI2 GNAI2 ATP1B3 ATP1B3 MFSD6L MFSD6L AKT1 AKT1 CACNA1F CACNA1F ATF6B ATF6B CREB3L3 CREB3L3 ATP1B2 ATP1B2 SLC9A1 SLC9A1 ATP1B1 ATP1B1 AKT3 AKT3 PPP2R5C PPP2R5C LOC102727336 LOC102727336 PTRHD1 PTRHD1 PLN PLN PPP1CB PPP1CB LOC102731583 LOC102731583 RAPGEF4 RAPGEF4 ATF2 ATF2 TNNI3 TNNI3 CACNA2D4 CACNA2D4 LOC102742813 LOC102742813 PPP2R2C PPP2R2C CACNB1 CACNB1 ATP1A2 ATP1A2 ATP1A4 ATP1A4 TPM3 TPM3 MAPK1 MAPK1 KCNE1 KCNE1 PPP2R5A PPP2R5A ACTRT3 ACTRT3 ADRA1D ADRA1D FXYD2 FXYD2 SCN4B SCN4B ADCY9 ADCY9 MYH1 MYH1 MYH13 MYH13 MYH3 MYH3 CALM3 CALM3 PPP2R5E PPP2R5E LOC102733606 LOC102733606 LOC102746012 LOC102746012 ADRA1B ADRA1B CACNG2 CACNG2 ATP1B4 ATP1B4 PLCB3 PLCB3 ATP2A3 ATP2A3 LOC102732031 LOC102732031 CREB3L1 CREB3L1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TPM2Tropomyosin alpha-4 chain isoform X1; Belongs to the tropomyosin family. (284 aa)
TNNT3Troponin T, fast skeletal muscle. (230 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (673 aa)
LOC102735730Sodium/potassium-transporting ATPase subunit alpha-1-like; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (346 aa)
PPP2R3BSerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta. (596 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
LOC102726374myosin-7B-like. (171 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
LOC102730623Beta-2 adrenergic receptor-like. (418 aa)
LOC102740654Phosphoinositide 3-kinase regulatory subunit 5-like. (111 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
LOC102730629Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa)
SLC39A12Zinc transporter ZIP12. (366 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha. (476 aa)
ARSIArylsulfatase I. (575 aa)
TPM4Tropomyosin alpha-4 chain; Belongs to the tropomyosin family. (248 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LOC102733954Calmodulin-like protein 4-like. (119 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102730020Myosin-7-like. (703 aa)
LOC102749357Myosin-4-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (342 aa)
LOC102749446Myosin-1-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (190 aa)
LOC102726696Myosin-2-like. (199 aa)
LOC102740174Myosin-2-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (236 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like 4. (199 aa)
LOC102735756alpha-1B adrenergic receptor-like. (213 aa)
EFCAB13LOW QUALITY PROTEIN: EF-hand calcium binding domain 13. (905 aa)
PPP1R1CProtein phosphatase 1 regulatory subunit 1C isoform X2. (109 aa)
LOC102736922Calmodulin-like; Belongs to the calmodulin family. (223 aa)
CACNA2D1Voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1. (1091 aa)
PPP2R3ASerine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1. (1153 aa)
SLC8A1Sodium/calcium exchanger 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (970 aa)
AGTR2Type-2 angiotensin II receptor; Belongs to the G-protein coupled receptor 1 family. (361 aa)
ATF7Cyclic AMP-dependent transcription factor ATF-7 isoform X2. (483 aa)
PPP1R1AProtein phosphatase 1 regulatory subunit 1A isoform X4. (171 aa)
CACNB3Voltage-dependent L-type calcium channel subunit beta-3 isoform X1. (484 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
CACNG5Voltage-dependent calcium channel gamma-5 subunit. (275 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (224 aa)
CACNG4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (327 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (351 aa)
SCN1BSodium channel subunit beta-1. (237 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (161 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
LOC102738071Calmodulin-like; Belongs to the calmodulin family. (113 aa)
LOC102726697Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
LOC102741278Sodium channel protein type 5 subunit alpha-like. (920 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (574 aa)
SLC8A3Sodium/calcium exchanger 3 isoform X3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
CREMcAMP-responsive element modulator isoform X1. (344 aa)
KCNQ1Potassium voltage-gated channel subfamily KQT member 1; Belongs to the potassium channel family. (599 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (613 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (676 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
ADRA1Aalpha-1A adrenergic receptor. (465 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1. (166 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CACNG6Voltage-dependent calcium channel gamma-6 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (260 aa)
MYL3Myosin light chain 3 isoform X1. (198 aa)
GNAI2Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (280 aa)
MFSD6LMajor facilitator superfamily domain-containing protein 6-like. (593 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
ATF6BCyclic AMP-dependent transcription factor ATF-6 beta. (623 aa)
CREB3L3Cyclic AMP-responsive element-binding protein 3-like protein 3. (466 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (817 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (524 aa)
LOC102727336Voltage-dependent calcium channel subunit alpha-2/delta-3-like. (239 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
LOC102731583Voltage-dependent calcium channel gamma-3 subunit-like. (315 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X1. (858 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X2. (505 aa)
TNNI3Troponin I, cardiac muscle isoform X1. (211 aa)
CACNA2D4Voltage-dependent calcium channel subunit alpha-2/delta-4. (1102 aa)
LOC102742813Neuroendocrine secretory protein 55-like. (246 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform. (231 aa)
CACNB1Voltage-dependent L-type calcium channel subunit beta-1 isoform X1. (643 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
ATP1A4Sodium/potassium-transporting ATPase subunit alpha. (1030 aa)
TPM3Tropomyosin alpha-3 chain isoform X1; Belongs to the tropomyosin family. (285 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
KCNE1Potassium voltage-gated channel subfamily E member 1 isoform X2. (124 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (486 aa)
ACTRT3Actin-related protein T3; Belongs to the actin family. (372 aa)
ADRA1Dalpha-1D adrenergic receptor. (509 aa)
FXYD2FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (66 aa)
SCN4BSodium channel subunit beta-4. (228 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
MYH1Myosin-1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2421 aa)
MYH13LOW QUALITY PROTEIN: myosin-13; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1946 aa)
MYH3Myosin-3; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa)
CALM3Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
LOC1027336061-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like. (156 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
ADRA1Balpha-1B adrenergic receptor. (345 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (252 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (360 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
ATP2A3Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. (604 aa)
LOC102732031Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (407 aa)
CREB3L1Cyclic AMP-responsive element-binding protein 3-like protein 1. (474 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
Server load: low (18%) [HD]