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GUCY1B3 GUCY1B3 CACNA1F CACNA1F MAP2K2 MAP2K2 ROCK2 ROCK2 RAF1 RAF1 LOC102750359 LOC102750359 PRKG1 PRKG1 PTRHD1 PTRHD1 PPP1CB PPP1CB AVPR1B AVPR1B ITPR1 ITPR1 EDN2 EDN2 LOC102742813 LOC102742813 MAPK1 MAPK1 ITPR3 ITPR3 NPR2 NPR2 LOC102739025 LOC102739025 ETV3L ETV3L ADRA1D ADRA1D ADCY9 ADCY9 GNA11 GNA11 PTGIR PTGIR LOC102738224 LOC102738224 CALM3 CALM3 PLA2G1B PLA2G1B LOC102733606 LOC102733606 LOC102746012 LOC102746012 ADRA1B ADRA1B KCNMB2 KCNMB2 KCNMB3 KCNMB3 MYH9 MYH9 PLCB3 PLCB3 LOC102729478 LOC102729478 ACTG2 ACTG2 NPR1 NPR1 LOC102734445 LOC102734445 PLA2G2E PLA2G2E ERF ERF ETV3 ETV3 ARHGEF12 ARHGEF12 PPP1CA PPP1CA LOC102730715 LOC102730715 PLA2G2F PLA2G2F LOC102734538 LOC102734538 ADORA2A ADORA2A AVPR1A AVPR1A PPP1R14A PPP1R14A RAMP2 RAMP2 AGT AGT MYLK3 MYLK3 LOC102742564 LOC102742564 LOC102731551 LOC102731551 PRKACA PRKACA LOC102733954 LOC102733954 LOC102731038 LOC102731038 LOC102745028 LOC102745028 LOC102736045 LOC102736045 LOC102731957 LOC102731957 CALML4 CALML4 LOC102735756 LOC102735756 EFCAB13 EFCAB13 LOC102734673 LOC102734673 ITPR2 ITPR2 PPP1CC PPP1CC PRKACB PRKACB ADRA1A ADRA1A JMJD7 JMJD7 LOC102731168 LOC102731168 RAMP3 RAMP3 NPPB NPPB NPPA NPPA KCNMB1 KCNMB1 PRKCQ PRKCQ LOC102735079 LOC102735079 NPPC NPPC PLA2G3 PLA2G3 LOC102734862 LOC102734862 KCNMB4 KCNMB4 LOC102738071 LOC102738071 LOC102750709 LOC102750709 ARHGEF1 ARHGEF1 PLA2G4D PLA2G4D PROCA1 PROCA1 PLA2G12B PLA2G12B ACTC1 ACTC1 LOC102747252 LOC102747252 GNA12 GNA12 MAP2K1 MAP2K1 ADCY6 ADCY6 ESYT1 ESYT1 MYL6 MYL6 PLA2G10 PLA2G10 LYVE1 LYVE1 MYH11 MYH11 MRVI1 MRVI1 ADM ADM GUCY1A3 GUCY1A3 PLA2G12A PLA2G12A LOC102736922 LOC102736922 CALCRL CALCRL
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GUCY1B3Guanylate cyclase soluble subunit beta-1 isoform X1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
CACNA1FVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1983 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
ROCK2Rho-associated protein kinase 2. (850 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
LOC102750359Myosin-9-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (163 aa)
PRKG1cGMP-dependent protein kinase 1. (193 aa)
PTRHD1Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
AVPR1BVasopressin V1b receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (420 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
EDN2Endothelin-2. (179 aa)
LOC102742813Neuroendocrine secretory protein 55-like. (246 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
ITPR3Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
NPR2Guanylate cyclase. (1047 aa)
LOC102739025Actin, alpha sarcomeric/skeletal-like; Belongs to the actin family. (128 aa)
ETV3LETS translocation variant 3-like protein. (361 aa)
ADRA1Dalpha-1D adrenergic receptor. (509 aa)
ADCY9Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
GNA11Guanine nucleotide-binding protein subunit alpha-11. (359 aa)
PTGIRProstacyclin receptor; Belongs to the G-protein coupled receptor 1 family. (384 aa)
LOC102738224LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like. (612 aa)
CALM3Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
PLA2G1BPhospholipase A(2). (146 aa)
LOC1027336061-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like. (156 aa)
LOC102746012Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
ADRA1Balpha-1B adrenergic receptor. (345 aa)
KCNMB2Calcium-activated potassium channel subunit beta-2. (235 aa)
KCNMB3LOW QUALITY PROTEIN: calcium-activated potassium channel subunit beta-3. (281 aa)
MYH9Myosin-9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1845 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
LOC102729478Endothelin-1 receptor-like; Belongs to the G-protein coupled receptor 1 family. (253 aa)
ACTG2Actin, gamma-enteric smooth muscle. (150 aa)
NPR1Atrial natriuretic peptide receptor 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (242 aa)
LOC102734445Phospholipase A(2). (145 aa)
PLA2G2EPhospholipase A(2). (142 aa)
ERFETS domain-containing transcription factor ERF. (549 aa)
ETV3ETS translocation variant 3. (522 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12-like. (932 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
PLA2G2FPhospholipase A(2). (210 aa)
LOC102734538Calcitonin gene-related peptide 1-like isoform X2. (128 aa)
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
AVPR1AVasopressin V1a receptor; Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl- inositol-calcium second messenger system. (381 aa)
PPP1R14AProtein phosphatase 1 regulatory subunit 14A. (147 aa)
RAMP2Receptor activity-modifying protein 2. (118 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
MYLK3Myosin light chain kinase 3. (99 aa)
LOC102742564Rho-associated protein kinase 2-like. (530 aa)
LOC102731551Actin, alpha skeletal muscle-like; Belongs to the actin family. (235 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LOC102733954Calmodulin-like protein 4-like. (119 aa)
LOC102731038Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
LOC102745028Endothelin-1 receptor-like. (178 aa)
LOC102736045Cytochrome P450 4A11-like. (350 aa)
LOC102731957Myosin light chain 6B-like isoform X1. (209 aa)
CALML4LOW QUALITY PROTEIN: calmodulin-like 4. (199 aa)
LOC102735756alpha-1B adrenergic receptor-like. (213 aa)
EFCAB13LOW QUALITY PROTEIN: EF-hand calcium binding domain 13. (905 aa)
LOC102734673Myosin-10-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (120 aa)
ITPR2Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
ADRA1Aalpha-1A adrenergic receptor. (465 aa)
JMJD7jmjC domain-containing protein 7. (316 aa)
LOC102731168LOW QUALITY PROTEIN: potassium channel subfamily U member 1-like. (1171 aa)
RAMP3Receptor activity-modifying protein 3. (116 aa)
NPPBNatriuretic peptides B. (132 aa)
NPPANatriuretic peptides A. (150 aa)
KCNMB1Calcium-activated potassium channel subunit beta-1. (191 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (706 aa)
LOC102735079Rho guanine nucleotide exchange factor 12-like. (163 aa)
NPPCC-type natriuretic peptide isoform X1. (126 aa)
PLA2G3Group 3 secretory phospholipase A2. (522 aa)
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
KCNMB4Calcium-activated potassium channel subunit beta-4. (210 aa)
LOC102738071Calmodulin-like; Belongs to the calmodulin family. (113 aa)
LOC102750709ETS domain-containing transcription factor ERF-like. (354 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (912 aa)
PLA2G4DPhospholipase A2. (817 aa)
PROCA1Protein PROCA1. (365 aa)
PLA2G12BGroup XIIB secretory phospholipase A2-like protein. (133 aa)
ACTC1Actin, alpha cardiac muscle 1 isoform X1. (377 aa)
LOC102747252Protein kinase C eta type-like. (89 aa)
GNA12Guanine nucleotide-binding protein subunit alpha-12 isoform X1. (305 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
ESYT1Extended synaptotagmin-1. (1100 aa)
MYL6Myosin light polypeptide 6 isoform X2. (151 aa)
PLA2G10Phospholipase A(2). (163 aa)
LYVE1Lymphatic vessel endothelial hyaluronic acid receptor 1. (325 aa)
MYH11Myosin-11 isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1979 aa)
MRVI1Protein MRVI1. (597 aa)
ADMADM. (188 aa)
GUCY1A3Guanylate cyclase soluble subunit alpha-3; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (690 aa)
PLA2G12AGroup XIIA secretory phospholipase A2. (190 aa)
LOC102736922Calmodulin-like; Belongs to the calmodulin family. (223 aa)
CALCRLCalcitonin gene-related peptide type 1 receptor; Belongs to the G-protein coupled receptor 2 family. (410 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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