STRINGSTRING
SKP1 SKP1 DKK2 DKK2 LEF1 LEF1 SFRP2 SFRP2 FHDC1 FHDC1 LGR4 LGR4 LOC102733521 LOC102733521 PPP3R2 PPP3R2 LOC102736212 LOC102736212 CHD1 CHD1 WNT16 WNT16 CCND3 CCND3 WNT1 WNT1 LOC102738538 LOC102738538 LOC102750498 LOC102750498 CHD7 CHD7 MAPK10 MAPK10 RBX1 RBX1 WDR92 WDR92 PPP3R1 PPP3R1 EP300 EP300 NFATC3 NFATC3 DAAM1 DAAM1 NKD1 NKD1 LOC102732739 LOC102732739 DAND5 DAND5 CXXC5 CXXC5 CUL1 CUL1 NLK NLK RSPO2 RSPO2 WIF1 WIF1 AXIN1 AXIN1 DVL1 DVL1 LOC102734953 LOC102734953 LRP6 LRP6 CACYBP CACYBP SENP2 SENP2 FZD5 FZD5 CAMK2G CAMK2G SOX7 SOX7 FZD7 FZD7 SMAD4 SMAD4 RNF43 RNF43 FZD3 FZD3 DKK4 DKK4 FZD2 FZD2 EFEMP1 EFEMP1 LOC102726711 LOC102726711 RYK RYK PRKACB PRKACB PPARD PPARD WNT8A WNT8A LOC102745156 LOC102745156 RUVBL1 RUVBL1 PRKX PRKX DVL3 DVL3 MAPK8 MAPK8 SFRP5 SFRP5 PORCN PORCN PRICKLE3 PRICKLE3 FRAT1 FRAT1 LY6G5B LY6G5B CSNK2B CSNK2B SFRP4 SFRP4 SOST SOST TCF7L1 TCF7L1 TP53 TP53 DVL2 DVL2 GPC4 GPC4 CHD2 CHD2 LOC102746796 LOC102746796 JUN JUN LGR6 LGR6 RSPO1 RSPO1 ROCK2 ROCK2 FZD10 FZD10 LOC102742901 LOC102742901 EFEMP2 EFEMP2 ROR1 ROR1 CTNND2 CTNND2 BAMBI BAMBI CSNK1A1 CSNK1A1 WNT5A WNT5A TBL1X TBL1X LOC102734300 LOC102734300 LOC102730272 LOC102730272 SOX17 SOX17 GSK3B GSK3B WNT5B WNT5B RAC2 RAC2 WNT10A WNT10A WNT6 WNT6 LRRC45 LRRC45 WNT11 WNT11 WNT3A WNT3A VANGL2 VANGL2 WNT9B WNT9B WNT3 WNT3 FZD9 FZD9 CER1 CER1 WNT4 WNT4 LGR5 LGR5 CCND1 CCND1 LOC102731813 LOC102731813 LRRC24 LRRC24 TLE2 TLE2 LOC102749983 LOC102749983 LOC102733606 LOC102733606 CTNNBIP1 CTNNBIP1 LOC102726140 LOC102726140 LOC102728864 LOC102728864 NFATC1 NFATC1 LOC102725943 LOC102725943 PLCB3 PLCB3 SFRP1 SFRP1 CREBBP CREBBP FZD4 FZD4 WISP3 WISP3 TLE3 TLE3 SNAPIN SNAPIN LOC102739552 LOC102739552 ZNRF3 ZNRF3 LOC102750211 LOC102750211 LOC102732238 LOC102732238 SOX18 SOX18 WNT2B WNT2B LOC102746055 LOC102746055 LOC102730715 LOC102730715 LOC102730318 LOC102730318 SIAH2 SIAH2 PRICKLE4 PRICKLE4 LOC102737660 LOC102737660 CAMK2A CAMK2A ARSI ARSI KCNK1 KCNK1 LOC102742564 LOC102742564 WNT8B WNT8B LOC102735556 LOC102735556 PRKACA PRKACA LOC102726484 LOC102726484 LOC102740668 LOC102740668 FRZB FRZB WNT10B WNT10B LOC102733273 LOC102733273 LOC102734473 LOC102734473
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SKP1S-phase kinase-associated protein 1 isoform X1; Belongs to the SKP1 family. (163 aa)
DKK2Dickkopf-related protein 2. (259 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
FHDC1FH2 domain-containing protein 1. (1015 aa)
LGR4Leucine-rich repeat-containing G-protein coupled receptor 4. (951 aa)
LOC102733521R-spondin-4-like. (154 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
LOC102736212F-box-like/WD repeat-containing protein TBL1X-like. (344 aa)
CHD1chromodomain-helicase-DNA-binding protein 1 isoform X1. (1797 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (149 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (291 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
LOC102738538Sentrin-specific protease 1-like. (93 aa)
LOC102750498Casein kinase II subunit alpha-like isoform X1; Belongs to the protein kinase superfamily. (391 aa)
CHD7chromodomain-helicase-DNA-binding protein 7. (2429 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X3. (108 aa)
WDR92WD repeat-containing protein 92. (357 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
EP300Histone acetyltransferase p300. (2425 aa)
NFATC3Nuclear factor of activated T-cells, cytoplasmic 3 isoform X1. (1075 aa)
DAAM1Disheveled-associated activator of morphogenesis 1. (226 aa)
NKD1Protein naked cuticle homolog 1. (363 aa)
LOC102732739Dickkopf-related protein 1-like. (268 aa)
DAND5DAN domain family member 5. (190 aa)
CXXC5CXXC-type zinc finger protein 5. (314 aa)
CUL1Cullin-1; Belongs to the cullin family. (327 aa)
NLKSerine/threonine-protein kinase NLK. (507 aa)
RSPO2R-spondin-2 isoform X1. (243 aa)
WIF1Wnt inhibitory factor 1. (379 aa)
AXIN1Axin-1 isoform X1. (867 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
LOC102734953CXXC-type zinc finger protein 4-like. (198 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
CACYBPCalcyclin-binding protein. (230 aa)
SENP2Sentrin-specific protease 2. (590 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
CAMK2GCalcium/calmodulin-dependent protein kinase type II subunit gamma. (574 aa)
SOX7Transcription factor SOX-7. (386 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
RNF43E3 ubiquitin-protein ligase RNF43 isoform X1. (781 aa)
FZD3Frizzled-3 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
DKK4Dickkopf-related protein 4. (221 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
EFEMP1EGF-containing fibulin-like extracellular matrix protein 1 isoform X1. (502 aa)
LOC102726711Uncharacterized protein C17orf64 homolog. (236 aa)
RYKTyrosine-protein kinase RYK. (475 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
PPARDPeroxisome proliferator-activated receptor delta isoform X1. (441 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (175 aa)
PRKXcAMP-dependent protein kinase catalytic subunit PRKX; Belongs to the protein kinase superfamily. (361 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
SFRP5Secreted frizzled-related protein 5. (289 aa)
PORCNProtein-cysteine N-palmitoyltransferase porcupine isoform X1; Belongs to the membrane-bound acyltransferase family. (461 aa)
PRICKLE3Prickle-like protein 3. (606 aa)
FRAT1Proto-oncogene FRAT1. (168 aa)
LY6G5BLymphocyte antigen 6 complex locus protein G5b. (195 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
SFRP4Secreted frizzled-related protein 4. (346 aa)
SOSTSclerostin. (213 aa)
TCF7L1Transcription factor 7-like 1. (438 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (734 aa)
GPC4Glypican-4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (283 aa)
CHD2chromodomain-helicase-DNA-binding protein 2. (1827 aa)
LOC102746796Vang-like protein 1-like. (264 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
LGR6Leucine-rich repeat-containing G-protein coupled receptor 6. (853 aa)
RSPO1R-spondin-1. (261 aa)
ROCK2Rho-associated protein kinase 2. (850 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
LOC102742901Glypican-6-like; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (267 aa)
EFEMP2EGF-containing fibulin-like extracellular matrix protein 2. (443 aa)
ROR1Tyrosine-protein kinase transmembrane receptor ROR1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (874 aa)
CTNND2Catenin delta-2. (292 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog. (237 aa)
CSNK1A1Casein kinase I isoform alpha; Belongs to the protein kinase superfamily. (227 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TBL1XF-box-like/WD repeat-containing protein TBL1X. (522 aa)
LOC102734300Matrilysin-like. (274 aa)
LOC102730272Transducin-like enhancer protein 4-like. (704 aa)
SOX17Transcription factor SOX-17-like. (406 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (261 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
LRRC45Leucine-rich repeat-containing protein 45. (670 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
VANGL2Vang-like protein. (521 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (218 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (407 aa)
CER1Cerberus. (274 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
LGR5Leucine-rich repeat-containing G-protein coupled receptor 5. (598 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
LOC102731813Frizzled-6-like; Belongs to the G-protein coupled receptor Fz/Smo family. (400 aa)
LRRC24Leucine-rich repeat-containing protein 24. (514 aa)
TLE2Transducin-like enhancer protein 2 isoform X1. (743 aa)
LOC102749983F-box/WD repeat-containing protein 11-like. (264 aa)
LOC1027336061-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like. (156 aa)
CTNNBIP1Beta-catenin-interacting protein 1. (81 aa)
LOC102726140Frizzled-1-like; Belongs to the G-protein coupled receptor Fz/Smo family. (647 aa)
LOC102728864R-spondin-4-like. (103 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
LOC102725943Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
SFRP1Secreted frizzled-related protein 1. (303 aa)
CREBBPCREB-binding protein-like. (1411 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
WISP3WNT1-inducible-signaling pathway protein 3. (354 aa)
TLE3Transducin-like enhancer protein 3-like isoform X5. (726 aa)
SNAPINSNARE-associated protein Snapin. (137 aa)
LOC102739552Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
ZNRF3E3 ubiquitin-protein ligase ZNRF3. (693 aa)
LOC102750211Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (154 aa)
LOC102732238Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (265 aa)
SOX18Transcription factor SOX-18. (186 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
LOC102746055E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (332 aa)
LOC1027307151-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (198 aa)
PRICKLE4Prickle-like protein 4. (387 aa)
LOC102737660Leucine-rich repeat-containing G-protein coupled receptor 5-like. (315 aa)
CAMK2ACalcium/calmodulin-dependent protein kinase type II subunit alpha. (476 aa)
ARSIArylsulfatase I. (575 aa)
KCNK1Potassium channel subfamily K member. (336 aa)
LOC102742564Rho-associated protein kinase 2-like. (530 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (322 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
LOC102726484Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (207 aa)
LOC102740668RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (335 aa)
FRZBSecreted frizzled-related protein 3-like. (306 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LOC102733273Glypican-4-like; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (222 aa)
LOC102734473E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (281 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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