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ACVR2B ACVR2B CREBBP CREBBP LOC102732118 LOC102732118 NODAL NODAL CDKN2A CDKN2A CDKN2B CDKN2B BMP6 BMP6 LTBP4 LTBP4 ID2 ID2 GREM2 GREM2 THSD4 THSD4 LOC102733506 LOC102733506 SMAD1 SMAD1 MAPK1 MAPK1 BMP7 BMP7 TGIF2 TGIF2 LOC102745999 LOC102745999 LEFTY1 LEFTY1 THBS1 THBS1 AMHR2 AMHR2 E2F4 E2F4 SP1 SP1 LOC102749080 LOC102749080 BAMBI BAMBI BMPR1A BMPR1A RPS6KB1 RPS6KB1 LTBP3 LTBP3 IFNG IFNG RGMA RGMA FST FST LOC102730764 LOC102730764 TFDP1 TFDP1 TNF TNF TGFB2 TGFB2 BMP8B BMP8B LOC102726900 LOC102726900 INHBB INHBB MATN4 MATN4 ACVR1 ACVR1 ACVR1C ACVR1C SMAD4 SMAD4 BMPR2 BMPR2 SMAD9 SMAD9 TGFBR2 TGFBR2 RBL1 RBL1 BMPR1B BMPR1B LOC102744413 LOC102744413 LOC102735151 LOC102735151 RPS6KB2 RPS6KB2 FSTL3 FSTL3 INHBE INHBE INHBC INHBC BMP2 BMP2 PITX1 PITX1 LOC102730318 LOC102730318 LOC102750017 LOC102750017 LOC102726566 LOC102726566 LOC102727675 LOC102727675 LOC102740547 LOC102740547 PKNOX1 PKNOX1 LOC102750402 LOC102750402 SNAPIN SNAPIN TGFB3 TGFB3 INHBA INHBA TGFB1 TGFB1 LOC102732031 LOC102732031 HFE2 HFE2 GDF5 GDF5 E2F5 E2F5 PITX2 PITX2 ID1 ID1 ACVR2A ACVR2A RGMB RGMB FBN2 FBN2 TGIF1 TGIF1 TGIF2LX TGIF2LX BMP5 BMP5 NOG NOG RBX1 RBX1 EP300 EP300 GREM1 GREM1 HAMP HAMP USF2 USF2 LOC102734040 LOC102734040 CUL1 CUL1 SKP1 SKP1 PITX3 PITX3 PPP2CB PPP2CB ZFYVE16 ZFYVE16 ZFYVE9 ZFYVE9 LOC102734862 LOC102734862
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (434 aa)
CREBBPCREB-binding protein-like. (1411 aa)
LOC102732118UPF0554 protein C2orf43 homolog isoform X1. (325 aa)
NODALNodal homolog. (348 aa)
CDKN2ACyclin-dependent kinase inhibitor 2A, isoforms 1/2/3. (152 aa)
CDKN2BCyclin-dependent kinase 4 inhibitor B. (138 aa)
BMP6Bone morphogenetic protein 6. (189 aa)
LTBP4Latent-transforming growth factor beta-binding protein 4. (1519 aa)
ID2DNA-binding protein inhibitor ID-2 isoform X2. (134 aa)
GREM2Gremlin. (168 aa)
THSD4Thrombospondin type-1 domain-containing protein 4-like isoform X2. (658 aa)
LOC102733506Latent-transforming growth factor beta-binding protein 1-like. (975 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
BMP7Bone morphogenetic protein 7-like. (312 aa)
TGIF2Homeobox protein TGIF2. (237 aa)
LOC102745999Left-right determination factor 1-like. (203 aa)
LEFTY1Left-right determination factor. (366 aa)
THBS1Thrombospondin-1 isoform X1. (1170 aa)
AMHR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (583 aa)
E2F4Transcription factor E2F4. (399 aa)
SP1Transcription factor Sp1 isoform X1. (786 aa)
LOC102749080Mothers against decapentaplegic homolog 5-like. (245 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog. (237 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
RPS6KB1Non-specific serine/threonine protein kinase. (445 aa)
LTBP3Latent-transforming growth factor beta-binding protein 3-like. (1159 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
RGMARepulsive guidance molecule A. (346 aa)
FSTFollistatin isoform X1. (344 aa)
LOC102730764Mothers against decapentaplegic homolog 2-like. (227 aa)
TFDP1Transcription factor. (290 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMP8BBone morphogenetic protein 8B. (169 aa)
LOC102726900Mothers against decapentaplegic homolog 7-like. (178 aa)
INHBBInhibin beta B chain. (320 aa)
MATN4Matrilin-4 isoform X2. (583 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (443 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (974 aa)
SMAD9Mothers against decapentaplegic homolog. (469 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
RBL1Retinoblastoma-like protein 1. (1068 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
LOC102744413Left-right determination factor 2-like. (165 aa)
LOC102735151Bone morphogenetic protein 7-like. (139 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
FSTL3Follistatin-related protein 3. (202 aa)
INHBEInhibin beta E chain. (351 aa)
INHBCInhibin beta C chain. (352 aa)
BMP2Bone morphogenetic protein 2-like. (395 aa)
PITX1Homeobox protein. (312 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
LOC102750017Mothers against decapentaplegic homolog 6-like. (181 aa)
LOC102726566Fibrillin-1-like. (1491 aa)
LOC102727675Decorin; May affect the rate of fibrils formation. (360 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
PKNOX1Homeobox protein PKNOX1 isoform X1. (436 aa)
LOC102750402E3 ubiquitin-protein ligase SMURF1-like. (321 aa)
SNAPINSNARE-associated protein Snapin. (137 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
INHBAInhibin beta A chain. (424 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
LOC102732031Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (407 aa)
HFE2Hemojuvelin-like isoform X1. (428 aa)
GDF5Growth/differentiation factor 5. (499 aa)
E2F5Transcription factor E2F5 isoform X1. (185 aa)
PITX2Homeobox protein. (325 aa)
ID1DNA-binding protein inhibitor ID-1. (154 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
RGMBRGM domain family member B. (482 aa)
FBN2Fibrillin-2. (2952 aa)
TGIF1Homeobox protein TGIF1 isoform X2. (272 aa)
TGIF2LXHomeobox protein TGIF2LX. (215 aa)
BMP5Bone morphogenetic protein 5 isoform X2. (454 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
RBX1E3 ubiquitin-protein ligase RBX1 isoform X3. (108 aa)
EP300Histone acetyltransferase p300. (2425 aa)
GREM1Gremlin. (184 aa)
HAMPHepcidin. (83 aa)
USF2Upstream stimulatory factor 2. (328 aa)
LOC102734040Zinc finger FYVE domain-containing protein 9-like. (577 aa)
CUL1Cullin-1; Belongs to the cullin family. (327 aa)
SKP1S-phase kinase-associated protein 1 isoform X1; Belongs to the SKP1 family. (163 aa)
PITX3Homeobox protein. (302 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
ZFYVE16Zinc finger FYVE domain-containing protein. (1536 aa)
ZFYVE9Zinc finger FYVE domain-containing protein 9. (746 aa)
LOC102734862Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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