(109 nodes) Apelin signaling pathway network (Leptonychotes weddellii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (817 aa)
	LOC102736922	Calmodulin-like; Belongs to the calmodulin family. (223 aa)
	SPP1	Osteopontin isoform X1. (299 aa)
	REM1	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (298 aa)
	KRAS	GTPase KRas isoform X2. (188 aa)
	MRAS	Ras-related protein M-Ras. (208 aa)
	SLC8A1	Sodium/calcium exchanger 1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (970 aa)
	NRAS	GTPase NRas. (189 aa)
	CSDE1	Cold shock domain-containing protein E1 isoform X1. (845 aa)
	NRF1	Nuclear respiratory factor 1 isoform X2. (503 aa)
	ADCY6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1161 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
	GEM	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (295 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (811 aa)
	CDH1	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (879 aa)
	GNG3	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
	UCP3	Mitochondrial uncoupling protein 3 isoform X1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (312 aa)
	UCP2	Mitochondrial uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
	LOC102751010	Nitric oxide synthase, inducible-like. (531 aa)
	RRAD	GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (308 aa)
	LOC102738071	Calmodulin-like; Belongs to the calmodulin family. (113 aa)
	GABARAPL1	Gamma-aminobutyric acid receptor-associated protein-like 1 isoform X1. (117 aa)
	LOC102729427	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
	GNGT1	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (74 aa)
	GNG11	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	LOC102726697	Guanine nucleotide-binding protein G(I) subunit alpha-1-like isoform X1. (354 aa)
	GNB5	Guanine nucleotide-binding protein subunit beta-5. (345 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	GNG10	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	SERPINE1	Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
	GNB2	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1. (340 aa)
	SLC8A3	Sodium/calcium exchanger 3 isoform X3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2550 aa)
	PRKACB	cAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
	GNG5	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
	MYL2	Myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1. (166 aa)
	EGR1	Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (542 aa)
	MYL3	Myosin light chain 3 isoform X1. (198 aa)
	GNAI2	Guanine nucleotide-binding protein G(I) subunit alpha-2. (303 aa)
	GNB3	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3. (340 aa)
	ITPR2	Inositol 1,4,5-trisphosphate receptor type 2-like. (2701 aa)
	MFSD6L	Major facilitator superfamily domain-containing protein 6-like. (593 aa)
	AKT1	Non-specific serine/threonine protein kinase. (518 aa)
	ERAS	GTPase ERas. (233 aa)
	LOC102730764	Mothers against decapentaplegic homolog 2-like. (227 aa)
	HDAC5	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1116 aa)
	MAP2K2	Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
	GABARAP	Gamma-aminobutyric acid receptor-associated protein. (117 aa)
	GNG13	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13. (67 aa)
	PRKAB1	5'-AMP-activated protein kinase subunit beta-1. (270 aa)
	CTGF	Connective tissue growth factor. (211 aa)
	LOC102745475	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1-like isoform X1. (340 aa)
	AKT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
	RPS6KB1	Non-specific serine/threonine protein kinase. (445 aa)
	HDAC4	Histone deacetylase 4-like. (667 aa)
	PTRHD1	Putative peptidyl-tRNA hydrolase PTRHD1. (140 aa)
	GNGT2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
	RPS6	40S ribosomal protein S6. (80 aa)
	ITPR1	Inositol 1,4,5-trisphosphate receptor type 1. (1244 aa)
	PRKAG2	5'-AMP-activated protein kinase subunit gamma-2-like isoform X2. (327 aa)
	LOC102748583	5'-AMP-activated protein kinase subunit gamma-2-like. (129 aa)
	PDE3B	Phosphodiesterase. (1180 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
	ITPR3	Inositol 1,4,5-trisphosphate receptor type 3. (557 aa)
	LOC102739025	Actin, alpha sarcomeric/skeletal-like; Belongs to the actin family. (128 aa)
	PLAT	Plasminogen activator; Belongs to the peptidase S1 family. (560 aa)
	TFAM	Transcription factor A, mitochondrial isoform X1. (246 aa)
	RRAS	Ras-related protein R-Ras. (218 aa)
	MEF2B	Myocyte-specific enhancer factor 2B. (368 aa)
	ADCY9	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (790 aa)
	CCND1	G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
	MEF2C	Myocyte-specific enhancer factor 2C-like isoform X2. (473 aa)
	PIK3R4	Phosphoinositide 3-kinase regulatory subunit 4. (1358 aa)
	GNG8	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
	CALM3	Calmodulin isoform X1; Belongs to the calmodulin family. (149 aa)
	LOC102733606	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3-like. (156 aa)
	SPHK2	Sphingosine kinase 2 isoform X1. (656 aa)
	LOC102746012	Adenylate cyclase type 3-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (311 aa)
	MEF2A	Myocyte-specific enhancer factor 2A isoform X1. (487 aa)
	LOC102736718	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
	PPARGC1A	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha-like isoform X2. (671 aa)
	GNG4	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
	PLCB3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1100 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
	SNAPIN	SNARE-associated protein Snapin. (137 aa)
	LOC102751087	Nitric oxide synthase, inducible-like. (430 aa)
	UCP1	Mitochondrial brown fat uncoupling protein 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (270 aa)
	LOC102730715	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like. (231 aa)
	CAMK4	Calcium/calmodulin-dependent protein kinase type IV. (360 aa)
	LOC102730318	Mothers against decapentaplegic homolog. (415 aa)
	GNB4	Guanine nucleotide-binding protein subunit beta-4. (340 aa)
	LOC102740654	Phosphoinositide 3-kinase regulatory subunit 5-like. (111 aa)
	LOC102748147	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
	MYLK3	Myosin light chain kinase 3. (99 aa)
	LOC102731551	Actin, alpha skeletal muscle-like; Belongs to the actin family. (235 aa)
	RPS6KB2	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (482 aa)
	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha isoform X1; Belongs to the protein kinase superfamily. (351 aa)
	LOC102733954	Calmodulin-like protein 4-like. (119 aa)
	LOC102732559	Apelin receptor-like; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	LOC102731038	Adenylate cyclase type 9-like; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (564 aa)
	LOC102740880	Nitric oxide synthase, endothelial-like. (619 aa)
	PLIN1	Perilipin-1-like. (766 aa)
	LOC102734169	Gamma-aminobutyric acid receptor-associated protein-like 2-like. (117 aa)
	PRKAG1	5'-AMP-activated protein kinase subunit gamma-1 isoform X1. (298 aa)
	CALML4	LOW QUALITY PROTEIN: calmodulin-like 4. (199 aa)
	EFCAB13	LOW QUALITY PROTEIN: EF-hand calcium binding domain 13. (905 aa)

Your Current Organism:

Leptonychotes weddellii

NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY6	ADCY9	A0A2U3XDB9	A0A2U3YLR7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.920
ADCY6	AKT1	A0A2U3XDB9	A0A2U3Y3V3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase.	0.819
ADCY6	AKT3	A0A2U3XDB9	A0A2U3Y8K7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.866
ADCY6	CALM3	A0A2U3XDB9	A0A2U3YN48	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin isoform X1; Belongs to the calmodulin family.	0.826
ADCY6	CALML4	A0A2U3XDB9	A0A2U3Z8V7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	LOW QUALITY PROTEIN: calmodulin-like 4.	0.858
ADCY6	CAMK4	A0A2U3XDB9	A0A2U3Z2E8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin-dependent protein kinase type IV.	0.884
ADCY6	EFCAB13	A0A2U3XDB9	A0A2U3ZA53	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	LOW QUALITY PROTEIN: EF-hand calcium binding domain 13.	0.482
ADCY6	GNAI2	A0A2U3XDB9	A0A2U3Y188	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I) subunit alpha-2.	0.826
ADCY6	GNB2	A0A2U3XDB9	A0A2U3XQS7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1.	0.820
ADCY6	GNB3	A0A2U3XDB9	A0A2U3Y2J3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3.	0.820
ADCY6	GNB4	A0A2U3XDB9	A0A2U3Z2R3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit beta-4.	0.802
ADCY6	GNB5	A0A2U3XDB9	A0A2U3XPJ8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit beta-5.	0.820
ADCY6	GNG10	A0A2U3XDB9	A0A2U3XQ47	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.822
ADCY6	GNG11	A0A2U3XDB9	A0A2U3XNE9	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.817
ADCY6	GNG13	A0A2U3XDB9	A0A2U3Y623	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13.	0.820
ADCY6	GNG2	A0A2U3XDB9	A0A2U3YSQ4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.817
ADCY6	GNG3	A0A2U3XDB9	A0A2U3XFZ3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.816
ADCY6	GNG4	A0A2U3XDB9	A0A2U3YRJ3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.817
ADCY6	GNG5	A0A2U3XDB9	A0A2U3XZW5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.813
ADCY6	GNG8	A0A2U3XDB9	A0A2U3YMQ8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.813