STRINGSTRING
SIRPB1 SIRPB1 LOC102729386 LOC102729386 TYK2 TYK2 JUND JUND LOC102725943 LOC102725943 NFATC1 NFATC1 PIK3CA PIK3CA FOS FOS CSF1 CSF1 PIK3CD PIK3CD IL1A IL1A IL1B IL1B LOC102735415 LOC102735415 ACP5 ACP5 NOX1 NOX1 NCF1 NCF1 IKBKB IKBKB MAPK1 MAPK1 TYROBP TYROBP CSF1R CSF1R CHUK CHUK STAT2 STAT2 TEC TEC IFNG IFNG AKT3 AKT3 JUN JUN IKBKG IKBKG FCGR2B FCGR2B LOC102735873 LOC102735873 IRF9 IRF9 FOSB FOSB TNF TNF AKT1 AKT1 TGFB2 TGFB2 MAPK8 MAPK8 TNFRSF1A TNFRSF1A BTK BTK TRAF6 TRAF6 IFNGR2 IFNGR2 MAP3K14 MAP3K14 LCP2 LCP2 MAPK12 MAPK12 ITGB3 ITGB3 SOCS3 SOCS3 LOC102748960 LOC102748960 TGFBR2 TGFBR2 MAP2K7 MAP2K7 CREB1 CREB1 IFNB1 IFNB1 CALCR CALCR NFKB1 NFKB1 NFKBIA NFKBIA MAP2K6 MAP2K6 KIAA1468 KIAA1468 JUNB JUNB SPI1 SPI1 PPP3R1 PPP3R1 MAPK10 MAPK10 LOC102741936 LOC102741936 TREM2 TREM2 NCF2 NCF2 PIK3R3 PIK3R3 LOC102726446 LOC102726446 PPP3R2 PPP3R2 LOC102751021 LOC102751021 LOC102735556 LOC102735556 LOC102739878 LOC102739878 LOC102744110 LOC102744110 LOC102749847 LOC102749847 MAPK11 MAPK11 LOC102749849 LOC102749849 NFKB2 NFKB2 TNFRSF11B TNFRSF11B NCF4 NCF4 CAMK4 CAMK4 SPIB SPIB IFNAR1 IFNAR1 LOC102737749 LOC102737749 LOC102749615 LOC102749615 TGFB1 TGFB1 LOC102734131 LOC102734131 LOC102736516 LOC102736516
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIRPB1Signal-regulatory protein beta-1 isoform 3. (175 aa)
LOC102729386Tyrosine-protein phosphatase non-receptor type substrate 1-like. (359 aa)
TYK2Non-receptor tyrosine-protein kinase TYK2-like. (767 aa)
JUNDTranscription factor jun-D. (298 aa)
LOC102725943Nuclear factor of activated T-cells, cytoplasmic 2-like. (160 aa)
NFATC1Nuclear factor of activated T-cells, cytoplasmic 1. (221 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FOSProto-oncogene c-Fos isoform X1. (380 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (547 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1043 aa)
IL1AInterleukin-1; Belongs to the IL-1 family. (265 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (270 aa)
LOC102735415Phosphoinositide phospholipase C. (309 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (335 aa)
NOX1NADPH oxidase 1 isoform X1. (564 aa)
NCF1Neutrophil cytosol factor 1. (380 aa)
IKBKBInhibitor of nuclear factor kappa-B kinase subunit beta isoform X1. (756 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (326 aa)
TYROBPTYRO protein tyrosine kinase-binding protein isoform X1. (111 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (961 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha. (745 aa)
STAT2Signal transducer and activator of transcription. (854 aa)
TECTyrosine-protein kinase. (630 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (418 aa)
JUNTranscription factor AP-1; Belongs to the bZIP family. (335 aa)
IKBKGNF-kappa-B essential modulator isoform X2. (419 aa)
FCGR2BLow affinity immunoglobulin gamma Fc region receptor II-b isoform X1. (314 aa)
LOC102735873Low affinity immunoglobulin gamma Fc region receptor III-like. (232 aa)
IRF9Interferon regulatory factor 9 isoform X1. (445 aa)
FOSBProtein fosB isoform X1. (335 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (233 aa)
AKT1Non-specific serine/threonine protein kinase. (518 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (358 aa)
BTKTyrosine-protein kinase. (659 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
IFNGR2Interferon gamma receptor 2. (115 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (852 aa)
SOCS3Suppressor of cytokine signaling 3. (225 aa)
LOC102748960Cytochrome b-245 light chain-like. (196 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
MAP2K7Dual specificity mitogen-activated protein kinase kinase 7 isoform X1. (435 aa)
CREB1Cyclic AMP-responsive element-binding protein 1 isoform X1. (341 aa)
IFNB1Interferon beta. (182 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (392 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit. (254 aa)
NFKBIANF-kappa-B inhibitor alpha isoform X2. (314 aa)
MAP2K6Dual specificity mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
KIAA1468lisH domain and HEAT repeat-containing protein KIAA1468 homolog isoform X1. (1214 aa)
JUNBTranscription factor jun-B. (347 aa)
SPI1Transcription factor PU.1. (250 aa)
PPP3R1Calcineurin subunit B type 1 isoform X1. (170 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
LOC102741936Trem-like transcript 1 protein-like. (128 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (261 aa)
NCF2Neutrophil cytosol factor 2 isoform X1. (526 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma. (461 aa)
LOC102726446Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like; Belongs to the PI3/PI4-kinase family. (235 aa)
PPP3R2Calcineurin subunit B type 2. (170 aa)
LOC102751021Phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1. (454 aa)
LOC102735556Mitogen-activated protein kinase 9-like. (134 aa)
LOC102739878Leukocyte immunoglobulin-like receptor subfamily B member 3-like. (131 aa)
LOC102744110Tumor necrosis factor ligand superfamily member 11-like; Belongs to the tumor necrosis factor family. (188 aa)
LOC102749847Tyrosine-protein kinase JAK1-like. (444 aa)
MAPK11Mitogen-activated protein kinase. (254 aa)
LOC102749849Microphthalmia-associated transcription factor-like. (181 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit. (900 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (401 aa)
NCF4Neutrophil cytosol factor 4. (342 aa)
CAMK4Calcium/calmodulin-dependent protein kinase type IV. (360 aa)
SPIBTranscription factor Spi-B isoform X1. (262 aa)
IFNAR1Interferon alpha/beta receptor 1. (560 aa)
LOC102737749Transcription factor RelB-like. (167 aa)
LOC102749615Four and a half LIM domains protein 2-like. (110 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
LOC102734131Fos-related antigen 2-like. (241 aa)
LOC102736516Phosphatidylinositol 3-kinase regulatory subunit alpha-like. (138 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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