STRINGSTRING
DVL3 DVL3 ACTG1 ACTG1 WNT10B WNT10B LLGL2 LLGL2 LOC102730127 LOC102730127 LOC102735453 LOC102735453 BIRC5 BIRC5 LOC102726484 LOC102726484 LOC102740573 LOC102740573 LOC102735151 LOC102735151 LOC102744822 LOC102744822 LOC102738369 LOC102738369 LOC102744498 LOC102744498 LOC102730629 LOC102730629 BMP2 BMP2 LOC102744495 LOC102744495 LOC102730318 LOC102730318 BIRC2 BIRC2 LOC102744093 LOC102744093 WNT2B WNT2B PPP1CA PPP1CA LOC102740547 LOC102740547 LOC102732432 LOC102732432 LOC102745732 LOC102745732 PARD6A PARD6A LOC102732238 LOC102732238 LOC102736228 LOC102736228 LOC102750211 LOC102750211 LOC102739552 LOC102739552 TP73 TP73 CSNK1E CSNK1E ACTL8 ACTL8 TGFB3 TGFB3 YWHAH YWHAH YAP1 YAP1 BIRC3 BIRC3 TGFB1 TGFB1 LOC102732031 LOC102732031 FZD4 FZD4 GDF5 GDF5 LOC102738827 LOC102738827 LOC102732118 LOC102732118 TEAD1 TEAD1 LOC102742022 LOC102742022 LOC102726140 LOC102726140 BMP6 BMP6 LOC102749983 LOC102749983 LOC102731813 LOC102731813 CCND1 CCND1 WNT4 WNT4 LOC102729978 LOC102729978 SMAD1 SMAD1 LOC102750756 LOC102750756 FZD9 FZD9 WNT3 WNT3 WNT9B WNT9B WNT3A WNT3A WNT11 WNT11 PPP2R2C PPP2R2C WNT6 WNT6 WNT10A WNT10A BMP7 BMP7 WWC1 WWC1 WNT5B WNT5B GSK3B GSK3B PPP1CB PPP1CB WNT5A WNT5A CSNK1D CSNK1D BMPR1A BMPR1A FZD10 FZD10 CTNNA1 CTNNA1 CTGF CTGF DLG4 DLG4 DVL2 DVL2 TCF7L1 TCF7L1 LOC102730764 LOC102730764 TGFB2 TGFB2 BMP8B BMP8B DLG3 DLG3 LOC102745156 LOC102745156 RASSF1 RASSF1 WNT8A WNT8A TEAD3 TEAD3 PPP1CC PPP1CC PPP2R2A PPP2R2A LOC102726900 LOC102726900 PRKCI PRKCI GLI2 GLI2 LOC102725698 LOC102725698 FZD2 FZD2 LATS1 LATS1 YWHAB YWHAB FZD3 FZD3 SMAD4 SMAD4 MPP5 MPP5 BMPR2 BMPR2 FZD7 FZD7 ACTB ACTB DLG2 DLG2 CRB1 CRB1 TGFBR2 TGFBR2 SERPINE1 SERPINE1 BMPR1B BMPR1B FZD5 FZD5 WWTR1 WWTR1 PRKCZ PRKCZ DVL1 DVL1 AXIN1 AXIN1 PARD6B PARD6B PPP2CB PPP2CB LOC102729919 LOC102729919 FRMD6 FRMD6 SAV1 SAV1 NKD1 NKD1 STK3 STK3 CDH1 CDH1 LOC102741253 LOC102741253 AFP AFP WNT1 WNT1 CCND3 CCND3 LOC102733831 LOC102733831 BMP5 BMP5 LOC102738933 LOC102738933 LRRC1 LRRC1 WNT16 WNT16 LATS2 LATS2 SNAI2 SNAI2 ID1 ID1 LOC102749407 LOC102749407 LEF1 LEF1
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
ACTG1LOW QUALITY PROTEIN: actin, gamma 1. (411 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
LLGL2Lethal(2) giant larvae protein homolog 2. (1021 aa)
LOC102730127Wilms tumor protein 1-interacting protein-like. (133 aa)
LOC102735453LIM domain-containing protein ajuba-like. (345 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (74 aa)
LOC102726484Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (207 aa)
LOC102740573Transcription factor SOX-3-like. (215 aa)
LOC102735151Bone morphogenetic protein 7-like. (139 aa)
LOC102744822Fibroblast growth factor 1; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins [...] (56 aa)
LOC102738369Merlin-like. (110 aa)
LOC10274449814-3-3 protein theta-like; Belongs to the 14-3-3 family. (98 aa)
LOC102730629Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (288 aa)
BMP2Bone morphogenetic protein 2-like. (395 aa)
LOC102744495Zinc finger protein GLI2-like. (460 aa)
LOC102730318Mothers against decapentaplegic homolog. (415 aa)
BIRC2Baculoviral IAP repeat-containing protein 2-like. (619 aa)
LOC102744093WW domain-containing transcription regulator protein 1-like. (286 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
LOC102740547Bone morphogenetic protein 4-like isoform X1. (409 aa)
LOC102732432Transcriptional enhancer factor TEF-4-like. (251 aa)
LOC102745732Leucine-rich repeat-containing protein 1-like. (92 aa)
PARD6APartitioning defective 6 homolog alpha isoform X1. (346 aa)
LOC102732238Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (265 aa)
LOC102736228Partitioning defective 3 homolog. (214 aa)
LOC102750211Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (154 aa)
LOC102739552Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (636 aa)
CSNK1ECasein kinase I isoform epsilon isoform X2. (359 aa)
ACTL8Actin-like protein 8; Belongs to the actin family. (366 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
YWHAH14-3-3 protein eta; Belongs to the 14-3-3 family. (246 aa)
YAP1Yorkie homolog. (326 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (604 aa)
TGFB1Transforming growth factor beta-1. (261 aa)
LOC102732031Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like. (407 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
GDF5Growth/differentiation factor 5. (499 aa)
LOC102738827Unconventional myosin-XV-like; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2226 aa)
LOC102732118UPF0554 protein C2orf43 homolog isoform X1. (325 aa)
TEAD1Transcriptional enhancer factor TEF-1 isoform X1. (305 aa)
LOC10274202214-3-3 protein zeta/delta-like isoform X1; Belongs to the 14-3-3 family. (245 aa)
LOC102726140Frizzled-1-like; Belongs to the G-protein coupled receptor Fz/Smo family. (647 aa)
BMP6Bone morphogenetic protein 6. (189 aa)
LOC102749983F-box/WD repeat-containing protein 11-like. (264 aa)
LOC102731813Frizzled-6-like; Belongs to the G-protein coupled receptor Fz/Smo family. (400 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (214 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (296 aa)
LOC102729978Beta-actin-like protein 2-like isoform X1. (376 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
LOC10275075614-3-3 protein epsilon-like; Belongs to the 14-3-3 family. (233 aa)
FZD9Frizzled-9; Belongs to the G-protein coupled receptor Fz/Smo family. (407 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (218 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform. (231 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (261 aa)
BMP7Bone morphogenetic protein 7-like. (312 aa)
WWC1Protein KIBRA. (967 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CSNK1DCasein kinase I isoform delta isoform X2. (399 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FZD10Frizzled-10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
CTNNA1Catenin alpha-1 isoform X1. (906 aa)
CTGFConnective tissue growth factor. (211 aa)
DLG4Disks large homolog 4 isoform X1; Belongs to the MAGUK family. (764 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (734 aa)
TCF7L1Transcription factor 7-like 1. (438 aa)
LOC102730764Mothers against decapentaplegic homolog 2-like. (227 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMP8BBone morphogenetic protein 8B. (169 aa)
DLG3Disks large homolog 3 isoform X1; Belongs to the MAGUK family. (512 aa)
LOC102745156Catenin beta-1-like isoform X1. (216 aa)
RASSF1Ras association domain-containing protein 1. (189 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
TEAD3Transcriptional enhancer factor TEF-5. (336 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
LOC102726900Mothers against decapentaplegic homolog 7-like. (178 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (543 aa)
GLI2Zinc finger protein GLI2. (556 aa)
LOC102725698Zinc finger protein GLI2-like. (368 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
LATS1Serine/threonine-protein kinase LATS1. (1127 aa)
YWHAB14-3-3 protein beta/alpha; Belongs to the 14-3-3 family. (244 aa)
FZD3Frizzled-3 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MPP5MAGUK p55 subfamily member 5; Belongs to the MAGUK family. (675 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (974 aa)
FZD7Frizzled-7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
ACTBActin, cytoplasmic 1. (375 aa)
DLG2Disks large homolog 2 isoform X1. (905 aa)
CRB1Protein crumbs homolog 1 isoform X1. (1406 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (564 aa)
SERPINE1Plasminogen activator inhibitor 1; Belongs to the serpin family. (402 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
WWTR1WW domain-containing transcription regulator protein 1. (144 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (557 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X1. (693 aa)
AXIN1Axin-1 isoform X1. (867 aa)
PARD6BPartitioning defective 6 homolog beta. (370 aa)
PPP2CBSerine/threonine-protein phosphatase. (308 aa)
LOC102729919Transcription factor SOX-2-like. (322 aa)
FRMD6FERM domain-containing protein 6-like isoform X1. (622 aa)
SAV1Protein salvador homolog 1. (384 aa)
NKD1Protein naked cuticle homolog 1. (363 aa)
STK3Serine/threonine-protein kinase 3 isoform X1. (491 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. (879 aa)
LOC102741253Amphiregulin-like. (253 aa)
AFPAlpha-fetoprotein. (609 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (291 aa)
LOC102733831Transcription factor SOX-3-like. (82 aa)
BMP5Bone morphogenetic protein 5 isoform X2. (454 aa)
LOC102738933Catenin alpha-3-like. (530 aa)
LRRC1Leucine-rich repeat-containing protein 1. (242 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (149 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
ID1DNA-binding protein inhibitor ID-1. (154 aa)
LOC102749407Catenin alpha-2-like. (304 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
Your Current Organism:
Leptonychotes weddellii
NCBI taxonomy Id: 9713
Other names: L. weddellii, Leptonychotes weddelli, Weddell seal
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